Application of Immunohistochemistry in Thyroid Pathology

Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective...

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Published in	Archives of pathology & laboratory medicine (1976) Vol. 139; no. 1; pp. 67 - 82
Main Authors	Liu, Haiyan, Lin, Fan
Format	Journal Article
Language	English
Published	United States College of American Pathologists 01.01.2015
Subjects	Biomarkers, Tumor - analysis Diagnosis, Differential Humans Immunohistochemistry Immunohistochemistry - methods Reproducibility of Results Sensitivity and Specificity Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism
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Abstract	Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management. To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013. Literature review, authors' research data, and personal practice experience. The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions.
AbstractList	Context.--Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management. Objective.--To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013. Data Sources.--Literature review, authors' research data, and personal practice experience. Conclusions.--The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions. (Arch Pathol Lab Med. 2015; 139:67-82; doi: 10.5858/arpa.2014-0056-RA) Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management. To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013. Literature review, authors' research data, and personal practice experience. The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions. (Arch Pathol Lab Med. 2015; 139:67-82; doi: 10.5858/arpa.2014-0056-RA) Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management.CONTEXTAccurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine-needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle and subjective. In the past decades, tremendous advances have been made in molecular gene profiling of tumors and diagnostic immunohistochemistry, aiding in diagnostic accuracy and proper patient management.To evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013.OBJECTIVETo evaluate the diagnostic utility of the most commonly studied immunomarkers in the field of thyroid pathology by review of the literature, using the database of indexed articles in PubMed (US National Library of Medicine) from 1976-2013.Literature review, authors' research data, and personal practice experience.DATA SOURCESLiterature review, authors' research data, and personal practice experience.The appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions.CONCLUSIONSThe appropriate use of immunohistochemistry by applying a panel of immunomarkers and using a standardized technical and interpretational method may complement the morphologic assessment and aid in the accurate classification of difficult thyroid lesions.
Audience	Professional Academic
Author	Liu, Haiyan Lin, Fan
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Snippet	Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic... Context.--Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic... (Arch Pathol Lab Med. 2015; 139:67-82; doi: 10.5858/arpa.2014-0056-RA)
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SubjectTerms	Biomarkers, Tumor - analysis Diagnosis, Differential Humans Immunohistochemistry Immunohistochemistry - methods Reproducibility of Results Sensitivity and Specificity Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Neoplasms - diagnosis Thyroid Neoplasms - metabolism
Title	Application of Immunohistochemistry in Thyroid Pathology
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