The core planar cell polarity gene, Vangl2, directs adult corneal epithelial cell alignment and migration

• Published in: Royal Society open science Vol. 3; no. 10; p. 160658
• Main Authors: Findlay, Amy S., Panzica, D. Alessio, Walczysko, Petr, Holt, Amy B., Henderson, Deborah J., West, John D., Rajnicek, Ann M., Collinson, J. Martin
• Format: Journal Article
• Language: English
• Published: England The Royal Society 01.10.2016
• Subjects: Cell Migration; Cornea; Epithelium; Genetics; Planar Cell Polarity; Vangl2; cell migration; Vangl2; epithelium; planar cell polarity; cornea

This study shows that the core planar cell polarity (PCP) genes direct the aligned cell migration in the adult corneal epithelium, a stratified squamous epithelium on the outer surface of the vertebrate eye. Expression of multiple core PCP genes was demonstrated in the adult corneal epithelium. PCP...