Circadian Disruption Leads to Insulin Resistance and Obesity

• Published in: Current biology Vol. 23; no. 5; pp. 372 - 381
• Main Authors: Shi, Shu-qun, Ansari, Tasneem S., McGuinness, Owen P., Wasserman, David H., Johnson, Carl Hirschie
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 04.03.2013
• Subjects: adipose tissue; adverse effects; Animals; ARNTL Transcription Factors; ARNTL Transcription Factors - genetics; ARNTL Transcription Factors - metabolism; blood; Circadian Rhythm; Diet, High-Fat; Diet, High-Fat - adverse effects; etiology; explants; genes; genetics; Glucose Clamp Technique; high fat diet; insulin; Insulin - blood; Insulin Resistance; Male; metabolic syndrome; metabolism; Mice; Mice, Knockout; noninsulin-dependent diabetes mellitus; obesity; Obesity - etiology; periodicity; risk

Disruption of circadian (daily) timekeeping enhances the risk of metabolic syndrome, obesity, and type 2 diabetes. While clinical observations have suggested that insulin action is not constant throughout the 24 hr cycle, its magnitude and periodicity have not been assessed. Moreover, when circadian...