Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer’s disease

• Published in: NeuroImage clinical Vol. 22; p. 101777
• Main Authors: Skouras, Stavros, Falcon, Carles, Tucholka, Alan, Rami, Lorena, Sanchez-Valle, Raquel, Lladó, Albert, Gispert, Juan D., Molinuevo, José Luís
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.01.2019; Elsevier
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - cerebrospinal fluid; Cognitive Dysfunction - cerebrospinal fluid; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Connectome - methods; Disease Progression; Eigenvector centrality; Female; Functional connectomics; Hippocampus; Hippocampus - diagnostic imaging; Hippocampus - physiopathology; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging; Male; Middle Aged; Neural capacity; Peptide Fragments - cerebrospinal fluid; Prodromal Symptoms; Radiology; Regular; Resting-state fMRI; tau Proteins - cerebrospinal fluid; ACC; AD; PCu; IPL; Neural capacity; Eigenvector centrality; Functional connectomics; MCC; ECM; PCC; MCI; Αβ42; P-tau; CSF; Resting-state fMRI; FC; Hippocampus; EC; BA; Eigenvector Centrality Mapping; phosphorylated tau protein; Inferior Parietal Lobule; Functional Connectivity; Precuneus; amyloid beta peptide 42; Alzheimer's disease; Anterior Cingulate Cortex; Brodmann Area; Cerebrospinal Fluid; Mild Cognitive Impairment; Middle Cingulate Cortex; Posterior Cingulate Cortex

Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-speci...