Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer’s disease
Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-speci...
Saved in:
| Published in | NeuroImage clinical Vol. 22; p. 101777 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier Inc
01.01.2019
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation.
Data from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups.
Centrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum.
Functional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas.
•BA39-BA19 centrality implicated in Alzheimer's disease.•Increasing centrality in cingulate and thalamus involved in functional compensation.•Preclinical functional alterations of hippocampus compensated by precuneus.•Cerebellar involvement in functional compensation. |
|---|---|
| AbstractList | Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation.BACKGROUNDMechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation.Data from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups.METHODSData from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups.Centrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum.RESULTSCentrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum.Functional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas.CONCLUSIONSFunctional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas. AbstractBackgroundMechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation. MethodsData from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups. ResultsCentrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum. ConclusionsFunctional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas. Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation. Data from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups. Centrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum. Functional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas. •BA39-BA19 centrality implicated in Alzheimer's disease.•Increasing centrality in cingulate and thalamus involved in functional compensation.•Preclinical functional alterations of hippocampus compensated by precuneus.•Cerebellar involvement in functional compensation. • BA39-BA19 centrality implicated in Alzheimer's disease. • Increasing centrality in cingulate and thalamus involved in functional compensation. • Preclinical functional alterations of hippocampus compensated by precuneus. • Cerebellar involvement in functional compensation. Background: Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation. Methods: Data from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups. Results: Centrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum. Conclusions: Functional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas. Keywords: Resting-state fMRI, Eigenvector centrality, Functional connectomics, Hippocampus, Neural capacity Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional connectomics in relation to cerebrospinal fluid (CSF) biomarkers across the pathophysiological continuum of AD, we identify disease-stage-specific patterns of functional degradation and functional compensation. Data from a sample of 96 participants, comprised of 49 controls, 11 preclinical AD subjects, 21 patients with mild cognitive impairment (MCI) due to AD and 15 patients with mild dementia due to AD, were analyzed. CSF ratio of phosphorylated tau protein over amyloid beta peptide 42 (p-tau/Aβ42) was computed and used as a marker of progression along the AD continuum. Whole-brain, voxel-wise eigenvector centrality mapping (ECM) was computed from resting-state fMRI and regression against p-tau/Aβ42 was performed. Surviving clusters were used as data-derived seeds in functional connectivity analyses and investigated in relation to memory performance scores (delayed free recall and memory alteration) via complementary regression models. To investigate disease-stage-specific effects, the whole-brain connectivity maps of each cluster were compared between progressive groups. Centrality in BA39-BA19 is negatively correlated with the p-tau/Aβ42 ratio and associated to memory function impairment across the AD continuum. The thalamus, anterior cingulate (ACC), midcingulate (MCC) and posterior cingulate cortex (PCC) show the opposite effect. The MCC shows the highest increase in centrality as memory performance decays. In the asymptomatic preclinical group, MCC shows reduced functional connectivity (FC) with the left hippocampus and stronger FC with the precuneus (PCu). Additionally, BA39-BA19 show reduced FC with the cerebellum, compensated by stronger FC between cerebellum and PCC. In the MCI group, PCC shows reduced FC with PCu, compensated by stronger FC with the left pars orbitalis, insula and temporal pole, as well as by stronger FC of MCC with its anterior and ventral neighboring areas and the cerebellum. In the mild dementia group, extensive functional decoupling occurs across the entire autobiographical memory network and functional resilience ensues in posterior regions and the cerebellum. Functional decoupling in preclinical AD occurs predominantly in AD-vulnerable regions (e.g. hippocampus, cerebellar lobule VI / Crus I, visual cortex, frontal pole) and coupling between MCC and PCu, as well as between PCC and cerebellum, emerge as intrinsic mechanisms of functional compensation. At the MCI stage, the PCu can no longer compensate for hippocampal decoupling, but the compensatory role of the MCC and PCC ensue into the stage of dementia. These findings shed light on the neural mechanisms of functional compensation across the pathophysiological continuum of AD, highlighting the compensatory roles of several key brain areas. |
| ArticleNumber | 101777 |
| Author | Sanchez-Valle, Raquel Falcon, Carles Molinuevo, José Luís Gispert, Juan D. Tucholka, Alan Skouras, Stavros Rami, Lorena Lladó, Albert |
| AuthorAffiliation | c Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain a Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain b Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigación Biomédica en Red de Bioingeniería, Madrid, Spain |
| AuthorAffiliation_xml | – name: a Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain – name: b Biomateriales y Nanomedicina (CIBER-BBN), Centro de Investigación Biomédica en Red de Bioingeniería, Madrid, Spain – name: c Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain |
| Author_xml | – sequence: 1 givenname: Stavros surname: Skouras fullname: Skouras, Stavros organization: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain – sequence: 2 givenname: Carles surname: Falcon fullname: Falcon, Carles organization: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain – sequence: 3 givenname: Alan surname: Tucholka fullname: Tucholka, Alan organization: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain – sequence: 4 givenname: Lorena surname: Rami fullname: Rami, Lorena organization: Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain – sequence: 5 givenname: Raquel surname: Sanchez-Valle fullname: Sanchez-Valle, Raquel organization: Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain – sequence: 6 givenname: Albert surname: Lladó fullname: Lladó, Albert organization: Alzheimer's Disease and Other Cognitive Disorders Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain – sequence: 7 givenname: Juan D. surname: Gispert fullname: Gispert, Juan D. organization: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain – sequence: 8 givenname: José Luís surname: Molinuevo fullname: Molinuevo, José Luís email: jlmolinuevo@barcelonabeta.org organization: Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30913531$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstuEzEUhkeoiJbSF2CBvGTRBF_Gc2GBVFVcKhWxANbWGc9J4jBjD7YnUrriJVjwejwJniRULRL1xrdzvnPs_3-aHVlnMcueMzpnlBWv1nNrdDfnlNXTQVmWj7ITzpmYMVnxozvr4-wshDVNo6K0LIon2bGgNRNSsJPs50fUK7Am9IG4BVmMVkfjLHREu35AG2DanpMWO2MRIrak2RI0S7Qb1NF5otFGD52JW9LDMBi7PCegvQuBxBWSAeLKDattMK5zS6N3ZBuNHcd-qnjR3azQ9Oh___gVSGsCQsBn2eMFdAHPDvNp9vXd2y-XH2bXn95fXV5cz7Qs8zhrZV1QVrWy1VRWtMFWNw1yDcBzBosCqqYseUsBUcgCZS11DhoakUsJpUBxml3tua2DtRq86cFvlQOjdgfOLxX4mP4ZVc2o1lIkmmhyLhmINpeIuuEtz2nBE-vNnjWMTZ862X_LPej9G2tWauk2qshFTus8AV4eAN59HzFE1ZugsevAohuD4qyuZCHzgqbQF3dr3Rb5q2sK4PuAnRAeF7chjKrJP2qtJv-oyT9q75-UVP2TpE3c6Z_6Nd3DqYfHY1JrY9Arnfwyqf0NtxjWbvTJU0ExFbii6vNkzsmbrBaU8VImwOv_A5Ia5qHqfwCctfps |
| CitedBy_id | crossref_primary_10_3389_fneur_2021_645171 crossref_primary_10_1152_jn_00027_2024 crossref_primary_10_1155_2020_9796419 crossref_primary_10_1016_j_nicl_2021_102900 crossref_primary_10_3389_fnagi_2020_550664 crossref_primary_10_3389_fncir_2019_00072 crossref_primary_10_1111_ene_14423 crossref_primary_10_3390_brainsci13010144 crossref_primary_10_3390_brainsci11101275 crossref_primary_10_3233_JAD_230055 crossref_primary_10_3389_fnagi_2021_715517 crossref_primary_10_3389_fneur_2021_629048 crossref_primary_10_3389_fnagi_2023_1165908 crossref_primary_10_3390_brainsci11111400 crossref_primary_10_1002_hbm_25686 crossref_primary_10_1007_s00234_021_02760_5 crossref_primary_10_1016_j_isci_2024_111194 crossref_primary_10_3389_fnagi_2022_919859 crossref_primary_10_1186_s12916_023_02952_1 crossref_primary_10_1186_s13195_024_01654_x crossref_primary_10_3389_fnagi_2021_695210 crossref_primary_10_4103_1673_5374_332161 crossref_primary_10_1016_j_neuroimage_2019_05_008 crossref_primary_10_1093_braincomms_fcad104 crossref_primary_10_3389_fnins_2022_1087176 crossref_primary_10_1016_j_gaitpost_2020_05_023 crossref_primary_10_1093_braincomms_fcae033 crossref_primary_10_1093_braincomms_fcad088 |
| Cites_doi | 10.1016/j.neuroimage.2005.09.059 10.1093/cercor/bhu132 10.1093/cercor/bhp008 10.1016/j.neuroimage.2005.12.033 10.1002/hbm.22335 10.1016/j.neuroimage.2009.08.050 10.1006/nimg.1996.0248 10.1016/j.neuron.2009.03.024 10.1016/j.socnet.2007.04.002 10.1016/j.jalz.2016.02.002 10.1016/j.mri.2007.03.009 10.3389/fninf.2013.00039 10.1016/j.neuroimage.2008.03.061 10.1016/j.media.2007.06.004 10.1016/j.brainresbull.2005.01.013 10.1016/j.jalz.2018.02.018 10.1109/TMI.2007.906087 10.1016/j.biopsycho.2014.06.008 10.1016/S1474-4422(12)70291-0 10.1038/s41467-017-01150-x 10.1016/j.neuroimage.2003.07.016 10.1126/science.1140801 10.1523/JNEUROSCI.1868-09.2009 10.1037/0894-4105.19.4.520 10.1089/brain.2016.0475 10.1109/TMI.2010.2046908 10.1089/brain.2014.0320 10.1093/brain/aww003 10.1016/j.socnet.2004.11.008 10.1016/j.neuroimage.2010.09.025 10.1371/journal.pone.0010232 10.1016/j.jneumeth.2006.11.004 10.1001/archneur.64.3.noc60123 10.2217/14796708.3.4.409 10.1177/1352458513516892 10.1016/j.jad.2006.05.035 10.1016/j.neuroimage.2010.07.033 10.1016/j.cub.2015.12.048 10.1001/archneur.60.9.1202 10.1016/j.neuroimage.2010.06.016 10.1016/j.neuroimage.2003.10.028 10.1002/hipo.20927 10.3758/CABN.3.4.255 10.1016/j.biopsych.2011.02.017 10.1016/j.neuroimage.2014.07.007 10.7554/eLife.22978 10.1016/j.neuroimage.2004.12.034 10.1016/j.socnet.2004.08.007 10.1002/gps.1672 10.1016/S1474-4422(15)00093-9 10.1162/jocn.1997.9.5.648 10.1016/j.neurobiolaging.2015.06.027 10.1002/hbm.22416 10.1016/j.jalz.2011.03.003 10.1073/pnas.1705513114 10.1093/brain/awl004 10.1002/hbm.22008 10.1093/brain/awy025 10.1089/brain.2012.0087 10.1111/j.1467-8721.2008.00570.x 10.1038/35094500 10.1016/j.neuroimage.2004.11.003 10.1002/hbm.20856 10.1212/01.wnl.0000267428.62582.aa 10.1016/j.neurobiolaging.2011.07.003 10.1016/j.biopsych.2012.11.028 10.1016/j.neuron.2010.02.005 10.1073/pnas.98.2.676 10.1212/01.wnl.0000435556.21319.e4 10.3233/JAD-130203 10.1016/j.neuroimage.2009.09.062 10.1136/jnnp.2010.207183 10.1016/j.tics.2013.08.012 10.2307/270732 10.1523/JNEUROSCI.5062-08.2009 10.1097/00001756-199702100-00032 10.1080/87565648709540361 10.1016/j.neubiorev.2013.03.009 10.1093/cercor/bhn113 10.1001/archpsyc.57.12.1115 |
| ContentType | Journal Article |
| Copyright | 2019 The Authors The Authors Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. 2019 The Authors 2019 |
| Copyright_xml | – notice: 2019 The Authors – notice: The Authors – notice: Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. – notice: 2019 The Authors 2019 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA |
| DOI | 10.1016/j.nicl.2019.101777 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2213-1582 |
| EndPage | 101777 |
| ExternalDocumentID | oai_doaj_org_article_910cc532d03b4251a3d45eecb2d24062 PMC6434094 30913531 10_1016_j_nicl_2019_101777 1_s2_0_S2213158219301275 S2213158219301275 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | .1- .FO 0R~ 1P~ 457 53G 5VS AAEDT AAEDW AAIKJ AALRI AAXUO AAYWO ABMAC ACGFS ACVFH ADBBV ADCNI ADEZE ADRAZ ADVLN AEUPX AEXQZ AFJKZ AFPUW AFRHN AFTJW AGHFR AIGII AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS APXCP BAWUL BCNDV DIK EBS EJD FDB GROUPED_DOAJ HYE HZ~ IPNFZ IXB KQ8 M41 M48 M~E O-L O9- OK1 RIG ROL RPM SSZ Z5R AFCTW AAYXX CITATION 0SF 6I. AACTN AAFTH CGR CUY CVF ECM EIF NCXOZ NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c574t-d596018d5dc0580bedcbbe2caa241af6a8b772d0aee356e595c4acab3455a73e3 |
| IEDL.DBID | M48 |
| ISSN | 2213-1582 |
| IngestDate | Wed Aug 27 01:31:29 EDT 2025 Thu Aug 21 18:06:56 EDT 2025 Fri Jul 11 14:59:53 EDT 2025 Thu Jan 02 22:58:50 EST 2025 Tue Jul 01 01:09:42 EDT 2025 Thu Apr 24 22:51:43 EDT 2025 Wed Jun 18 06:48:26 EDT 2025 Tue Aug 26 16:33:04 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | ACC AD PCu IPL Neural capacity Eigenvector centrality Functional connectomics MCC ECM PCC MCI Αβ42 P-tau CSF Resting-state fMRI FC Hippocampus EC BA Eigenvector Centrality Mapping phosphorylated tau protein Inferior Parietal Lobule Functional Connectivity Precuneus amyloid beta peptide 42 Alzheimer's disease Anterior Cingulate Cortex Brodmann Area Cerebrospinal Fluid Mild Cognitive Impairment Middle Cingulate Cortex Posterior Cingulate Cortex |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c574t-d596018d5dc0580bedcbbe2caa241af6a8b772d0aee356e595c4acab3455a73e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1016/j.nicl.2019.101777 |
| PMID | 30913531 |
| PQID | 2198565460 |
| PQPubID | 23479 |
| PageCount | 1 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_910cc532d03b4251a3d45eecb2d24062 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6434094 proquest_miscellaneous_2198565460 pubmed_primary_30913531 crossref_primary_10_1016_j_nicl_2019_101777 crossref_citationtrail_10_1016_j_nicl_2019_101777 elsevier_clinicalkeyesjournals_1_s2_0_S2213158219301275 elsevier_clinicalkey_doi_10_1016_j_nicl_2019_101777 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | NeuroImage clinical |
| PublicationTitleAlternate | Neuroimage Clin |
| PublicationYear | 2019 |
| Publisher | Elsevier Inc Elsevier |
| Publisher_xml | – name: Elsevier Inc – name: Elsevier |
| References | Brown, Behrmann (bb0100) 2017; 114 Iglói, Doeller, Paradis, Benchenane, Berthoz, Burgess (bb0235) 2015; 25 Aggleton, Pralus, Nelson, Hornberger (bb0010) 2016 Wesson, Luchins (bb0495) 1992; 149 Gusnard, Raichle (bb0215) 2001; 2 Jack, Wiste, Weigand, Knopman, Lowe, Vemuri (bb0245) 2013; 81 Li, Sokal, Quinn, Leverenz, Brodey, Schellenberg, Kaye, Raskind, Zhang, Peskind (bb0300) 2007; 69 Hill, Laird, Robinson (bb0230) 2014; 102 Albada, Robinson (bb0015) 2007; 161 Lohmann, Neumann, Müller (bb0310) 2008 Schnell, Dietrich, Schnitker, Daumann (bb0395) 2007; 97 Backus, Schoffelen, Szebényi, Hanslmayr (bb0055) 2016; 26 Binnewijzend, Schoonheim (bb0065) 2012; 33 Adriaanse, Wink, Tijms, Ossenkoppele, Verfaillie, Lammertsma, Boellaard, Scheltens, van Berckel, Barkhof (bb0005) 2016; 6 Tustison, Avants (bb0465) 2013; 7 Molinuevo, Gispert, Dubois, Heneka, Lleo, Engelborghs (bb0340) 2013; 36 Driessen, Herrmann, Stahl (bb0135) 2000; 57 Söderlund, Moscovitch, Kumar, Mandic (bb0435) 2012; 22 Wink, de Munck, van der Werf, van den Heuvel, Barkhof (bb0500) 2012; 2 Binnewijzend, Adriaanse, Flier, Teunissen, Munck, Stam (bb0070) 2014; 35 Bäckman, Jones, Berger, Laukka (bb0050) 2005; 19 Buckner, Sepulcre, Talukdar, Krienen, Liu, Hedden (bb0105) 2009; 29 Fagan, Roe, Xiong (bb0155) 2007; 64 Hesling, Clément, Bordessoules, Allard (bb0225) 2005; 24 Skouras, Gispert, Molinuevo (bb0425) 2018; 141 Pihlajamäki, Sperling (bb0355) 2008; 3 Dickerson, Bakkour, Salat, Feczko, Pacheco (bb0130) 2009; 19 Tustison, Avants, Cook, Zheng, Egan, Yushkevich (bb0470) 2010; 29 Cavanna, Trimble (bb0110) 2006; 129 Wager, Smith (bb0485) 2003; 3 Lohmann, Margulies, Horstmann, Pleger, Lepsien, Goldhahn (bb0315) 2010; 5 Dubois, Hampel, Feldman, Scheltens, Aisen, Andrieu, Bakardjian, Benali, Bertram, Blennow (bb0140) 2016; 12 Sadananthan, Zheng, Chee, Zagorodnov (bb0390) 2010; 49 Ethofer, Anders, Erb, Herbert, Wiethoff (bb0150) 2006; 30 Lohmann, Müller, Bosch, Mentzel, Hessler (bb0305) 2000 Leal, Landau, Bell, Jagust (bb0290) 2017; 6 Volz, Schubotz, von Cramon (bb0480) 2004; 21 Rami, Molinuevo, Sanchez-Valle (bb0370) 2007; 22 Coupé, Yger, Prima, Hellier, Kervrann, Barillot (bb0115) 2008; 27 Bonacich (bb0085) 2007; 29 Borgatti (bb0095) 2005; 27 Smith, Nichols (bb0430) 2009; 44 Tustison, Avants, Cook (bb0475) 2013 Fonov, Evans, Botteron, Almli, McKinstry, Collins (bb0170) 2011; 54 Grober, Buschke (bb0200) 1987; 3 Maddalena, Papassotiropoulos, Müller-Tillmanns, Jung, Hegi, Nitsch, Hock (bb0320) 2003; 60 Spreng, Stevens, Chamberlain, Gilmore, Schacter (bb0445) 2010; 53 Wang, Zang, He, Liang, Zhang, Tian (bb0490) 2006; 31 Avants, Yushkevich, Pluta, Minkoff, Korczykowski, Detre (bb0040) 2010; 49 Babiloni, Ferretti, Gratta, Carducci (bb0045) 2005; 65 Seeley, Crawford, Zhou, Miller, Greicius (bb0405) 2009; 62 Teipel, Drzezga, Grothe, Barthel (bb0460) 2015; 14 Fisher (bb0165) 1921; 1 Reuter-Lorenz, Cappell (bb0380) 2008; 17 Fisher (bb0160) 1915; 10 Andrews-Hanna, Reidler, Sepulcre, Poulin, Buckner (bb0020) 2010; 65 Eickhoff, Stephan, Mohlberg, Grefkes, Fink, Amunts, Zilles (bb2000) 2005; 25 Langville, Meyer (bb0285) 2006 Strassnig, Ganguli (bb0450) 2005; 2 Bonacich, Lloyd (bb0090) 2004; 26 Martinelli, Sperduti, Piolino (bb0325) 2013; 34 Shulman, Fiez, Corbetta, Buckner, Miezen, Raichle (bb0415) 1997; 9 Ghaem, Mellet, Crivello, Tzourio, Mazoyer (bb0185) 1997; 8 Gispert, Rami, Sánchez-Benavides, Falcon, Tucholka, Rojas (bb0195) 2015; 36 Habas, Kamdar, Nguyen, Prater (bb0220) 2009; 29 Gilbert SJ, Dumontheil I, Simons JS, Frith CD, Burgess PW (2007): Comment on “Wandering minds: the default network and stimulus-independent thought.” Science 317:43. Avants, Tustison, Song, Cook, Klein, Gee (bb0035) 2010; 54 Bonacich (bb0080) 1972; 4 Jack, Bennett, Blennow, Carrillo, Dunn, Haeberlein (bb3000) 2018; 14 Jacobs, Radua, Lückmann (bb0250) 2013; 37 Jack, Knopman, Jagust, Petersen, Weiner, Aisen (bb0240) 2013; 12 Skouras, Gray, Critchley, Koelsch (bb0420) 2014; 101 Fortea, Sala-Llonch, Bartrés-Faz, Lladó (bb0175) 2011; 70 Elman, Madison, Baker, Vogel, Marks, Crowley (bb0145) 2016; 26 Zhang, Leung, Johnson (bb0505) 2003; 20 de Souza, Lamari, Belliard, Jardel, Houillier, De Paz (bb0125) 2011; 82 Raichle, MacLeod, Snyder, Powers, Gusnard (bb0365) 2001; 98 Palmqvist, Schöll, Strandberg, Mattsson, Stomrud, Zetterberg, Blennow, Landau, Jagust, Hansson (bb0350) 2017; 8 Cox, Chen, Glen, Reynolds, Taylor (bb0120) 2017; 7 Grober, Ocepek-Welikson, Teresi (bb0205) 2009; 51 Lemieux, Salek-Haddadi, Lund, Laufs (bb0295) 2007; 25 Barulli, Stern (bb0060) 2013; 17 Gallichan, Scholz, Bartsch, Behrens, Robson, Miller (bb0180) 2010; 31 Poline, Worsley, Evans, Friston (bb0360) 1997; 5 Avants, Tustison, Song (bb0030) 2009; 2 Janata (bb0255) 2009; 19 Avants, Epstein, Grossman, Gee (bb0025) 2008; 12 Guo, Tan, Hodges, Hu, Sami (bb0210) 2016; 139 Koelsch, Skouras (bb0270) 2014; 35 Sheline, Raichle (bb0410) 2013; 74 Sperling, Aisen, Beckett, Bennett, Craft, Fagan, Iwatsubo, Jack, Kaye, Montine, Park (bb0440) 2011; 7 Schoonheim, Geurts, Wiebenga, De Munck, Polman, Stam, Barkhof, Wink (bb0400) 2014; 20 Backus (10.1016/j.nicl.2019.101777_bb0055) 2016; 26 Binnewijzend (10.1016/j.nicl.2019.101777_bb0065) 2012; 33 Dubois (10.1016/j.nicl.2019.101777_bb0140) 2016; 12 Grober (10.1016/j.nicl.2019.101777_bb0205) 2009; 51 Jack (10.1016/j.nicl.2019.101777_bb0240) 2013; 12 Avants (10.1016/j.nicl.2019.101777_bb0040) 2010; 49 Bäckman (10.1016/j.nicl.2019.101777_bb0050) 2005; 19 Lohmann (10.1016/j.nicl.2019.101777_bb0305) 2000 Wesson (10.1016/j.nicl.2019.101777_bb0495) 1992; 149 Fonov (10.1016/j.nicl.2019.101777_bb0170) 2011; 54 Gispert (10.1016/j.nicl.2019.101777_bb0195) 2015; 36 Ethofer (10.1016/j.nicl.2019.101777_bb0150) 2006; 30 Wang (10.1016/j.nicl.2019.101777_bb0490) 2006; 31 Skouras (10.1016/j.nicl.2019.101777_bb0425) 2018; 141 Iglói (10.1016/j.nicl.2019.101777_bb0235) 2015; 25 Zhang (10.1016/j.nicl.2019.101777_bb0505) 2003; 20 Teipel (10.1016/j.nicl.2019.101777_bb0460) 2015; 14 Bonacich (10.1016/j.nicl.2019.101777_bb0090) 2004; 26 Gusnard (10.1016/j.nicl.2019.101777_bb0215) 2001; 2 Martinelli (10.1016/j.nicl.2019.101777_bb0325) 2013; 34 Gallichan (10.1016/j.nicl.2019.101777_bb0180) 2010; 31 Tustison (10.1016/j.nicl.2019.101777_bb0465) 2013; 7 Aggleton (10.1016/j.nicl.2019.101777_bb0010) 2016 Cavanna (10.1016/j.nicl.2019.101777_bb0110) 2006; 129 Schnell (10.1016/j.nicl.2019.101777_bb0395) 2007; 97 Elman (10.1016/j.nicl.2019.101777_bb0145) 2016; 26 Fisher (10.1016/j.nicl.2019.101777_bb0160) 1915; 10 Li (10.1016/j.nicl.2019.101777_bb0300) 2007; 69 Sperling (10.1016/j.nicl.2019.101777_bb0440) 2011; 7 Langville (10.1016/j.nicl.2019.101777_bb0285) 2006 Bonacich (10.1016/j.nicl.2019.101777_bb0085) 2007; 29 Leal (10.1016/j.nicl.2019.101777_bb0290) 2017; 6 Söderlund (10.1016/j.nicl.2019.101777_bb0435) 2012; 22 Volz (10.1016/j.nicl.2019.101777_bb0480) 2004; 21 Adriaanse (10.1016/j.nicl.2019.101777_bb0005) 2016; 6 Lemieux (10.1016/j.nicl.2019.101777_bb0295) 2007; 25 Borgatti (10.1016/j.nicl.2019.101777_bb0095) 2005; 27 Avants (10.1016/j.nicl.2019.101777_bb0030) 2009; 2 Sheline (10.1016/j.nicl.2019.101777_bb0410) 2013; 74 Fagan (10.1016/j.nicl.2019.101777_bb0155) 2007; 64 Lohmann (10.1016/j.nicl.2019.101777_bb0315) 2010; 5 Habas (10.1016/j.nicl.2019.101777_bb0220) 2009; 29 Smith (10.1016/j.nicl.2019.101777_bb0430) 2009; 44 Skouras (10.1016/j.nicl.2019.101777_bb0420) 2014; 101 Cox (10.1016/j.nicl.2019.101777_bb0120) 2017; 7 Hill (10.1016/j.nicl.2019.101777_bb0230) 2014; 102 Poline (10.1016/j.nicl.2019.101777_bb0360) 1997; 5 de Souza (10.1016/j.nicl.2019.101777_bb0125) 2011; 82 Avants (10.1016/j.nicl.2019.101777_bb0035) 2010; 54 10.1016/j.nicl.2019.101777_bb0190 Molinuevo (10.1016/j.nicl.2019.101777_bb0340) 2013; 36 Avants (10.1016/j.nicl.2019.101777_bb0025) 2008; 12 Fisher (10.1016/j.nicl.2019.101777_bb0165) 1921; 1 Hesling (10.1016/j.nicl.2019.101777_bb0225) 2005; 24 Shulman (10.1016/j.nicl.2019.101777_bb0415) 1997; 9 Guo (10.1016/j.nicl.2019.101777_bb0210) 2016; 139 Wager (10.1016/j.nicl.2019.101777_bb0485) 2003; 3 Buckner (10.1016/j.nicl.2019.101777_bb0105) 2009; 29 Janata (10.1016/j.nicl.2019.101777_bb0255) 2009; 19 Lohmann (10.1016/j.nicl.2019.101777_bb0310) 2008 Brown (10.1016/j.nicl.2019.101777_bb0100) 2017; 114 Coupé (10.1016/j.nicl.2019.101777_bb0115) 2008; 27 Jack (10.1016/j.nicl.2019.101777_bb3000) 2018; 14 Bonacich (10.1016/j.nicl.2019.101777_bb0080) 1972; 4 Grober (10.1016/j.nicl.2019.101777_bb0200) 1987; 3 Binnewijzend (10.1016/j.nicl.2019.101777_bb0070) 2014; 35 Rami (10.1016/j.nicl.2019.101777_bb0370) 2007; 22 Schoonheim (10.1016/j.nicl.2019.101777_bb0400) 2014; 20 Strassnig (10.1016/j.nicl.2019.101777_bb0450) 2005; 2 Ghaem (10.1016/j.nicl.2019.101777_bb0185) 1997; 8 Andrews-Hanna (10.1016/j.nicl.2019.101777_bb0020) 2010; 65 Spreng (10.1016/j.nicl.2019.101777_bb0445) 2010; 53 Driessen (10.1016/j.nicl.2019.101777_bb0135) 2000; 57 Seeley (10.1016/j.nicl.2019.101777_bb0405) 2009; 62 Jack (10.1016/j.nicl.2019.101777_bb0245) 2013; 81 Palmqvist (10.1016/j.nicl.2019.101777_bb0350) 2017; 8 Albada (10.1016/j.nicl.2019.101777_bb0015) 2007; 161 Koelsch (10.1016/j.nicl.2019.101777_bb0270) 2014; 35 Wink (10.1016/j.nicl.2019.101777_bb0500) 2012; 2 Babiloni (10.1016/j.nicl.2019.101777_bb0045) 2005; 65 Tustison (10.1016/j.nicl.2019.101777_bb0470) 2010; 29 Reuter-Lorenz (10.1016/j.nicl.2019.101777_bb0380) 2008; 17 Barulli (10.1016/j.nicl.2019.101777_bb0060) 2013; 17 Maddalena (10.1016/j.nicl.2019.101777_bb0320) 2003; 60 Dickerson (10.1016/j.nicl.2019.101777_bb0130) 2009; 19 Fortea (10.1016/j.nicl.2019.101777_bb0175) 2011; 70 Eickhoff (10.1016/j.nicl.2019.101777_bb2000) 2005; 25 Pihlajamäki (10.1016/j.nicl.2019.101777_bb0355) 2008; 3 Sadananthan (10.1016/j.nicl.2019.101777_bb0390) 2010; 49 Jacobs (10.1016/j.nicl.2019.101777_bb0250) 2013; 37 Tustison (10.1016/j.nicl.2019.101777_bb0475) 2013 Raichle (10.1016/j.nicl.2019.101777_bb0365) 2001; 98 |
| References_xml | – volume: 97 start-page: 253 year: 2007 end-page: 259 ident: bb0395 article-title: Processing of autobiographical memory retrieval cues in borderline personality disorder publication-title: J. Affect. Disord. – volume: 7 start-page: 280 year: 2011 end-page: 292 ident: bb0440 article-title: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. – volume: 24 start-page: 937 year: 2005 end-page: 947 ident: bb0225 article-title: Cerebral mechanisms of prosodic integration: evidence from connected speech publication-title: Neuroimage – volume: 12 start-page: 26 year: 2008 end-page: 41 ident: bb0025 article-title: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain publication-title: Med. Image Anal. – volume: 62 start-page: 42 year: 2009 end-page: 52 ident: bb0405 article-title: Neurodegenerative diseases target large-scale human brain networks publication-title: Neuron – volume: 31 start-page: 193 year: 2010 end-page: 202 ident: bb0180 article-title: Addressing a systematic vibration artifact in diffusion-weighted MRI publication-title: Hum. Brain Mapp. – volume: 8 start-page: 1214 year: 2017 ident: bb0350 article-title: Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity publication-title: Nat. Commun. – volume: 7 start-page: 39 year: 2013 ident: bb0465 article-title: Explicit B-spline regularization in diffeomorphic image registration publication-title: Front. Neuroinform. – reference: Gilbert SJ, Dumontheil I, Simons JS, Frith CD, Burgess PW (2007): Comment on “Wandering minds: the default network and stimulus-independent thought.” Science 317:43. – year: 2008 ident: bb0310 article-title: The Multiple Comparison Problem in Fmri - a New Method Based on Anatomical Priors – volume: 54 start-page: 2033 year: 2010 end-page: 2044 ident: bb0035 article-title: A reproducible evaluation of ANTs similarity metric performance in brain image registration publication-title: Neuroimage – volume: 17 start-page: 177 year: 2008 end-page: 182 ident: bb0380 article-title: Neurocognitive aging and the compensation hypothesis publication-title: Curr. Dir. Psychol. Sci. – volume: 141 year: 2018 ident: bb0425 article-title: The crus exhibits stronger functional connectivity with executive network nodes than with the default mode network publication-title: Brain – volume: 20 start-page: 1531 year: 2003 end-page: 1539 ident: bb0505 article-title: Frontal activations associated with accessing and evaluating information in working memory: an fMRI study publication-title: Neuroimage – volume: 53 start-page: 303 year: 2010 end-page: 317 ident: bb0445 article-title: Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition publication-title: Neuroimage – volume: 2 start-page: 685 year: 2001 end-page: 694 ident: bb0215 article-title: Searching for a baseline: functional imaging and the resting human brain publication-title: Nat. Rev. Neurosci. – volume: 19 start-page: 497 year: 2009 end-page: 510 ident: bb0130 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in in asymptomatic amyloid-positive individuals publication-title: Cereb. Cortex – volume: 2 start-page: 265 year: 2012 end-page: 274 ident: bb0500 article-title: Fast eigenvector centrality mapping of voxel-wise connectivity in functional magnetic resonance imaging: implementation, validation, and interpretation publication-title: Brain Connectivity – volume: 70 start-page: 183 year: 2011 end-page: 190 ident: bb0175 article-title: Cognitively preserved subjects with transitional cerebrospinal fluid ss-amyloid 1-42 values have thicker cortex in Alzheimer's disease vulnerable areas publication-title: Biol. Psychiatry – volume: 26 start-page: 450 year: 2016 end-page: 457 ident: bb0055 article-title: Hippocampal-prefrontal theta oscillations support memory integration publication-title: Curr. Biol. – volume: 29 start-page: 1310 year: 2010 end-page: 1320 ident: bb0470 article-title: N4ITK: improved N3 bias correction publication-title: IEEE Ttans. Med. Imaging – volume: 44 start-page: 83 year: 2009 end-page: 98 ident: bb0430 article-title: Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference publication-title: Neuroimage – volume: 34 start-page: 1515 year: 2013 end-page: 1529 ident: bb0325 article-title: Neural substrates of the self-memory system: new insights from a meta-analysis publication-title: Hum. Brain Mapp. – volume: 14 start-page: 1037 year: 2015 end-page: 1053 ident: bb0460 article-title: Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection publication-title: Lancet Neurol. – volume: 51 start-page: 266 year: 2009 end-page: 282 ident: bb0205 article-title: The free and cued selective reminding test: evidence of psychometric adequacy publication-title: Psychol. Sci. Q. – volume: 19 start-page: 2579 year: 2009 end-page: 2594 ident: bb0255 article-title: The neural architecture of music-evoked autobiographical memories publication-title: Cereb. Cortex – volume: 29 start-page: 1860 year: 2009 end-page: 1873 ident: bb0105 article-title: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease publication-title: J. Neurosci. – volume: 31 start-page: 496 year: 2006 end-page: 504 ident: bb0490 article-title: Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI publication-title: Neuroimage – volume: 26 start-page: 331 year: 2004 end-page: 338 ident: bb0090 article-title: Calculating status with negative relations publication-title: Soc. Networks – volume: 4 start-page: 176 year: 1972 end-page: 185 ident: bb0080 article-title: Technique for analyzing overlapping memberships publication-title: Sociol. Methodol. – volume: 3 start-page: 409 year: 2008 end-page: 421 ident: bb0355 article-title: fMRI: use in early Alzheimer's disease and in clinical trials publication-title: Future Neurol. – volume: 49 start-page: 225 year: 2010 end-page: 239 ident: bb0390 article-title: Skull stripping using graph cuts publication-title: NeuroImage – volume: 12 start-page: 292 year: 2016 end-page: 323 ident: bb0140 article-title: Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria publication-title: Alzheimer's Dementia – volume: 69 start-page: 631 year: 2007 end-page: 639 ident: bb0300 article-title: CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment a follow-up study publication-title: Neurology – volume: 57 start-page: 1115 year: 2000 end-page: 1122 ident: bb0135 article-title: Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization publication-title: Arch. Gen. Psychiatry – volume: 81 start-page: 1732 year: 2013 end-page: 1740 ident: bb0245 article-title: Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity publication-title: Neurology – volume: 25 start-page: 894 year: 2007 end-page: 901 ident: bb0295 article-title: Modelling large motion events in fMRI studies of patients with epilepsy publication-title: Magn. Reson. Imaging – volume: 19 start-page: 520 year: 2005 ident: bb0050 article-title: Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis publication-title: Neuropsychology – volume: 54 start-page: 313 year: 2011 end-page: 327 ident: bb0170 article-title: Unbiased average age-appropriate atlases for pediatric studies publication-title: NeuroImage – volume: 60 start-page: 1202 year: 2003 end-page: 1206 ident: bb0320 article-title: Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to β-amyloid peptide42 publication-title: Arch. Neurol. – volume: 21 start-page: 848 year: 2004 end-page: 857 ident: bb0480 article-title: Why am I unsure? Internal and external attributions of uncertainty dissociated by fMRI publication-title: Neuroimage – volume: 129 start-page: 564 year: 2006 end-page: 583 ident: bb0110 article-title: The precuneus: a review of its functional anatomy and behavioural correlates publication-title: Brain – volume: 27 start-page: 55 year: 2005 end-page: 71 ident: bb0095 article-title: Centrality and network flow publication-title: Soc. Networks – volume: 2 start-page: 30 year: 2005 end-page: 33 ident: bb0450 article-title: About a peculiar disease of the cerebral cortex: Alzheimer's original case revisited publication-title: Psychiatry (Edgmont) – volume: 22 start-page: 670 year: 2012 end-page: 679 ident: bb0435 article-title: As time goes by: hippocampal connectivity changes with remoteness of autobiographical memory retrieval publication-title: Hippocampus – year: 2013 ident: bb0475 article-title: The ANTs Cortical Thickness Processing Pipeline – volume: 29 start-page: 8586 year: 2009 end-page: 8594 ident: bb0220 article-title: Distinct cerebellar contributions to intrinsic connectivity networks publication-title: J. Neurosci. – volume: 82 start-page: 240 year: 2011 end-page: 246 ident: bb0125 article-title: Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias publication-title: J. Neurol. Neurosurg. Psychiatry – volume: 20 start-page: 1058 year: 2014 end-page: 1065 ident: bb0400 article-title: Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple sclerosis publication-title: Mult. Scler. J. – volume: 65 start-page: 550 year: 2010 end-page: 562 ident: bb0020 article-title: Functional-anatomic fractionation of the brain's default network publication-title: Neuron – volume: 64 start-page: 343 year: 2007 end-page: 349 ident: bb0155 article-title: Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults publication-title: Arch. Neurol. – volume: 10 start-page: 507 year: 1915 end-page: 521 ident: bb0160 article-title: Frequency distribution of the values of the correlation coefficient in samples of an indefinitely large population publication-title: Biometrika – volume: 3 start-page: 255 year: 2003 end-page: 274 ident: bb0485 article-title: Neuroimaging studies of working memory publication-title: Cogn. Affect. Behav. Neurosci. – volume: 114 start-page: E3368 year: 2017 end-page: E3369 ident: bb0100 article-title: Controversy in statistical analysis of functional magnetic resonance imaging data publication-title: PNAS – volume: 36 start-page: 2687 year: 2015 end-page: 2701 ident: bb0195 article-title: Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype publication-title: Neurobiol. Aging – volume: 102 start-page: 18 year: 2014 end-page: 29 ident: bb0230 article-title: Gender differences in working memory networks: a BrainMap meta-analysis publication-title: Biol. Psychol. – volume: 98 start-page: 676 year: 2001 end-page: 682 ident: bb0365 article-title: A default mode of brain function publication-title: PNAS – year: 2016 ident: bb0010 article-title: Thalamic pathology and memory loss in early Alzheimer's disease: moving the focus from the medial temporal lobe to Papez circuit – volume: 65 start-page: 383 year: 2005 end-page: 390 ident: bb0045 article-title: Human cortical responses during one-bit delayed-response tasks: an fMRI study publication-title: Brain Res. Bull. – start-page: 31 year: 2006 end-page: 46 ident: bb0285 article-title: The Mathematics of Google's PageRank publication-title: Google's PageRank and Beyond: The Science of Search Engine Rankings – volume: 9 start-page: 648 year: 1997 end-page: 663 ident: bb0415 article-title: Common blood flow changes across visual tasks, II: decreases in cerebral cortex publication-title: J. Cogn. Neurosci. – volume: 7 start-page: 152 year: 2017 end-page: 171 ident: bb0120 article-title: FMRI clustering in AFNI: false-positive rates redux publication-title: Brain Connectivity – volume: 25 start-page: 1325 year: 2005 end-page: 1335 ident: bb2000 article-title: A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data publication-title: NeuroImage – volume: 35 start-page: 3485 year: 2014 end-page: 3498 ident: bb0270 article-title: Functional centrality of amygdala, striatum and hypothalamus in a “small-world” network underlying joy: An fMRI study with music publication-title: Hum. Brain Mapp. – volume: 161 start-page: 205 year: 2007 end-page: 211 ident: bb0015 article-title: Transformation of arbitrary distributions to the normal distribution with application to EEG test–retest reliability publication-title: J. Neurosci. Methods – volume: 36 start-page: 67 year: 2013 end-page: 77 ident: bb0340 article-title: The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study publication-title: J. Alzheimers Dis. – volume: 29 start-page: 555 year: 2007 end-page: 564 ident: bb0085 article-title: Some unique properties of eigenvector centrality publication-title: Soc. Networks – volume: 8 start-page: 739 year: 1997 end-page: 744 ident: bb0185 article-title: Mental navigation along memorized routes activates the hippocampus, precuneus, and insula publication-title: Neuroreport – volume: 17 start-page: 502 year: 2013 end-page: 509 ident: bb0060 article-title: Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve publication-title: Trends Cogn. Sci. – volume: 30 start-page: 580 year: 2006 end-page: 587 ident: bb0150 article-title: Cerebral pathways in processing of affective prosody: a dynamic causal modeling study publication-title: Neuroimage – volume: 22 start-page: 294 year: 2007 end-page: 304 ident: bb0370 article-title: Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@ T (memory alteration test) in the primary care population publication-title: Int. J. Geriatric Psychiatry – volume: 2 start-page: 1 year: 2009 end-page: 35 ident: bb0030 article-title: Advanced normalization tools (ANTS) publication-title: Insight – volume: 3 start-page: 13 year: 1987 end-page: 36 ident: bb0200 article-title: Genuine memory deficits in dementia publication-title: Dev. Neuropsychol. – volume: 25 start-page: 4146 year: 2015 end-page: 4154 ident: bb0235 article-title: Interaction between hippocampus and cerebellum crus I in sequence-based but not place-based navigation publication-title: Cereb. Cortex – volume: 5 year: 2010 ident: bb0315 article-title: Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain publication-title: PLoS One – volume: 101 start-page: 364 year: 2014 end-page: 369 ident: bb0420 article-title: Superficial amygdala and hippocampal activity during affective music listening at 3 T but not 1.5 T fMRI publication-title: NeuroImage – volume: 149 start-page: 190 year: 1992 end-page: 194 ident: bb0495 article-title: An empirical evaluation of the global deterioration scale for staging Alzheimer's disease publication-title: Am. J. Psychiatry – volume: 12 start-page: 207 year: 2013 end-page: 216 ident: bb0240 article-title: Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers publication-title: Lancet Neurol. – volume: 37 start-page: 753 year: 2013 end-page: 765 ident: bb0250 article-title: Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker publication-title: Neurosci. Biobehav. Rev. – volume: 1 start-page: 3 year: 1921 end-page: 32 ident: bb0165 article-title: On the 'probable error' of a coefficient of correlation deduced from a small sample publication-title: Metron. – year: 2000 ident: bb0305 article-title: LIPSIA-Leipzig Image Processing and Statistical Inference Algorithms – volume: 35 start-page: 2383 year: 2014 end-page: 2393 ident: bb0070 article-title: Brain network alterations in Alzheimer's disease measured by eigenvector centrality in fMRI are related to cognition and CSF biomarkers publication-title: Hum. Brain Mapp. – volume: 27 start-page: 425 year: 2008 end-page: 441 ident: bb0115 article-title: An optimized blockwise nonlocal means denoising filter for 3-D magnetic resonance images publication-title: Med. Imag. IEEE Trans. – volume: 74 start-page: 340 year: 2013 end-page: 347 ident: bb0410 article-title: Resting state functional connectivity in preclinical Alzheimer's disease publication-title: Biol. Psychiatry – volume: 139 start-page: 1527 year: 2016 end-page: 1538 ident: bb0210 article-title: Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia publication-title: Brain – volume: 6 year: 2017 ident: bb0290 article-title: Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline publication-title: eLife – volume: 49 start-page: 2457 year: 2010 end-page: 2466 ident: bb0040 article-title: The optimal template effect in hippocampus studies of diseased populations publication-title: Neuroimage – volume: 6 start-page: 1 year: 2016 end-page: 8 ident: bb0005 article-title: The association of glucose metabolism and eigenvector centrality in Alzheimer's disease publication-title: Brain Connectivity – volume: 33 start-page: 2018 year: 2012 end-page: 2028 ident: bb0065 article-title: Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment publication-title: Neurobiol. Aging – volume: 26 start-page: 695 year: 2016 end-page: 707 ident: bb0145 article-title: Effects of beta-amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability publication-title: Cereb. Cortex – volume: 14 start-page: 535 year: 2018 end-page: 562 ident: bb3000 article-title: NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease publication-title: Alzheimers Dement. – volume: 5 start-page: 83 year: 1997 end-page: 96 ident: bb0360 article-title: Combining spatial extent and peak intensity to test for activations in functional imaging publication-title: Neuroimage – volume: 30 start-page: 580 year: 2006 ident: 10.1016/j.nicl.2019.101777_bb0150 article-title: Cerebral pathways in processing of affective prosody: a dynamic causal modeling study publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.09.059 – volume: 10 start-page: 507 issue: 4 year: 1915 ident: 10.1016/j.nicl.2019.101777_bb0160 article-title: Frequency distribution of the values of the correlation coefficient in samples of an indefinitely large population publication-title: Biometrika – volume: 25 start-page: 4146 year: 2015 ident: 10.1016/j.nicl.2019.101777_bb0235 article-title: Interaction between hippocampus and cerebellum crus I in sequence-based but not place-based navigation publication-title: Cereb. Cortex doi: 10.1093/cercor/bhu132 – volume: 19 start-page: 2579 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0255 article-title: The neural architecture of music-evoked autobiographical memories publication-title: Cereb. Cortex doi: 10.1093/cercor/bhp008 – volume: 31 start-page: 496 year: 2006 ident: 10.1016/j.nicl.2019.101777_bb0490 article-title: Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2005.12.033 – volume: 35 start-page: 2383 year: 2014 ident: 10.1016/j.nicl.2019.101777_bb0070 article-title: Brain network alterations in Alzheimer's disease measured by eigenvector centrality in fMRI are related to cognition and CSF biomarkers publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.22335 – volume: 49 start-page: 225 issue: 1 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0390 article-title: Skull stripping using graph cuts publication-title: NeuroImage doi: 10.1016/j.neuroimage.2009.08.050 – volume: 5 start-page: 83 issue: 2 year: 1997 ident: 10.1016/j.nicl.2019.101777_bb0360 article-title: Combining spatial extent and peak intensity to test for activations in functional imaging publication-title: Neuroimage doi: 10.1006/nimg.1996.0248 – volume: 62 start-page: 42 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0405 article-title: Neurodegenerative diseases target large-scale human brain networks publication-title: Neuron doi: 10.1016/j.neuron.2009.03.024 – volume: 29 start-page: 555 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0085 article-title: Some unique properties of eigenvector centrality publication-title: Soc. Networks doi: 10.1016/j.socnet.2007.04.002 – volume: 12 start-page: 292 year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0140 article-title: Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria publication-title: Alzheimer's Dementia doi: 10.1016/j.jalz.2016.02.002 – volume: 25 start-page: 894 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0295 article-title: Modelling large motion events in fMRI studies of patients with epilepsy publication-title: Magn. Reson. Imaging doi: 10.1016/j.mri.2007.03.009 – volume: 7 start-page: 39 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0465 article-title: Explicit B-spline regularization in diffeomorphic image registration publication-title: Front. Neuroinform. doi: 10.3389/fninf.2013.00039 – volume: 149 start-page: 190 year: 1992 ident: 10.1016/j.nicl.2019.101777_bb0495 article-title: An empirical evaluation of the global deterioration scale for staging Alzheimer's disease publication-title: Am. J. Psychiatry – volume: 44 start-page: 83 issue: 1 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0430 article-title: Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference publication-title: Neuroimage doi: 10.1016/j.neuroimage.2008.03.061 – volume: 12 start-page: 26 year: 2008 ident: 10.1016/j.nicl.2019.101777_bb0025 article-title: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain publication-title: Med. Image Anal. doi: 10.1016/j.media.2007.06.004 – volume: 65 start-page: 383 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb0045 article-title: Human cortical responses during one-bit delayed-response tasks: an fMRI study publication-title: Brain Res. Bull. doi: 10.1016/j.brainresbull.2005.01.013 – volume: 14 start-page: 535 year: 2018 ident: 10.1016/j.nicl.2019.101777_bb3000 article-title: NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2018.02.018 – volume: 27 start-page: 425 year: 2008 ident: 10.1016/j.nicl.2019.101777_bb0115 article-title: An optimized blockwise nonlocal means denoising filter for 3-D magnetic resonance images publication-title: Med. Imag. IEEE Trans. doi: 10.1109/TMI.2007.906087 – volume: 102 start-page: 18 year: 2014 ident: 10.1016/j.nicl.2019.101777_bb0230 article-title: Gender differences in working memory networks: a BrainMap meta-analysis publication-title: Biol. Psychol. doi: 10.1016/j.biopsycho.2014.06.008 – volume: 12 start-page: 207 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0240 article-title: Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(12)70291-0 – volume: 8 start-page: 1214 year: 2017 ident: 10.1016/j.nicl.2019.101777_bb0350 article-title: Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity publication-title: Nat. Commun. doi: 10.1038/s41467-017-01150-x – volume: 20 start-page: 1531 year: 2003 ident: 10.1016/j.nicl.2019.101777_bb0505 article-title: Frontal activations associated with accessing and evaluating information in working memory: an fMRI study publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.07.016 – ident: 10.1016/j.nicl.2019.101777_bb0190 doi: 10.1126/science.1140801 – volume: 29 start-page: 8586 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0220 article-title: Distinct cerebellar contributions to intrinsic connectivity networks publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1868-09.2009 – volume: 19 start-page: 520 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb0050 article-title: Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis publication-title: Neuropsychology doi: 10.1037/0894-4105.19.4.520 – volume: 7 start-page: 152 issue: 3 year: 2017 ident: 10.1016/j.nicl.2019.101777_bb0120 article-title: FMRI clustering in AFNI: false-positive rates redux publication-title: Brain Connectivity doi: 10.1089/brain.2016.0475 – volume: 29 start-page: 1310 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0470 article-title: N4ITK: improved N3 bias correction publication-title: IEEE Ttans. Med. Imaging doi: 10.1109/TMI.2010.2046908 – start-page: 31 year: 2006 ident: 10.1016/j.nicl.2019.101777_bb0285 article-title: The Mathematics of Google's PageRank – volume: 6 start-page: 1 year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0005 article-title: The association of glucose metabolism and eigenvector centrality in Alzheimer's disease publication-title: Brain Connectivity doi: 10.1089/brain.2014.0320 – volume: 139 start-page: 1527 year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0210 article-title: Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia publication-title: Brain doi: 10.1093/brain/aww003 – volume: 27 start-page: 55 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb0095 article-title: Centrality and network flow publication-title: Soc. Networks doi: 10.1016/j.socnet.2004.11.008 – volume: 54 start-page: 2033 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0035 article-title: A reproducible evaluation of ANTs similarity metric performance in brain image registration publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.09.025 – volume: 1 start-page: 3 year: 1921 ident: 10.1016/j.nicl.2019.101777_bb0165 article-title: On the 'probable error' of a coefficient of correlation deduced from a small sample publication-title: Metron. – volume: 5 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0315 article-title: Eigenvector centrality mapping for analyzing connectivity patterns in fMRI data of the human brain publication-title: PLoS One doi: 10.1371/journal.pone.0010232 – volume: 161 start-page: 205 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0015 article-title: Transformation of arbitrary distributions to the normal distribution with application to EEG test–retest reliability publication-title: J. Neurosci. Methods doi: 10.1016/j.jneumeth.2006.11.004 – volume: 64 start-page: 343 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0155 article-title: Cerebrospinal fluid tau/β-amyloid42 ratio as a prediction of cognitive decline in nondemented older adults publication-title: Arch. Neurol. doi: 10.1001/archneur.64.3.noc60123 – volume: 3 start-page: 409 year: 2008 ident: 10.1016/j.nicl.2019.101777_bb0355 article-title: fMRI: use in early Alzheimer's disease and in clinical trials publication-title: Future Neurol. doi: 10.2217/14796708.3.4.409 – volume: 20 start-page: 1058 year: 2014 ident: 10.1016/j.nicl.2019.101777_bb0400 article-title: Changes in functional network centrality underlie cognitive dysfunction and physical disability in multiple sclerosis publication-title: Mult. Scler. J. doi: 10.1177/1352458513516892 – volume: 97 start-page: 253 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0395 article-title: Processing of autobiographical memory retrieval cues in borderline personality disorder publication-title: J. Affect. Disord. doi: 10.1016/j.jad.2006.05.035 – volume: 54 start-page: 313 year: 2011 ident: 10.1016/j.nicl.2019.101777_bb0170 article-title: Unbiased average age-appropriate atlases for pediatric studies publication-title: NeuroImage doi: 10.1016/j.neuroimage.2010.07.033 – volume: 26 start-page: 450 year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0055 article-title: Hippocampal-prefrontal theta oscillations support memory integration publication-title: Curr. Biol. doi: 10.1016/j.cub.2015.12.048 – volume: 60 start-page: 1202 year: 2003 ident: 10.1016/j.nicl.2019.101777_bb0320 article-title: Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to β-amyloid peptide42 publication-title: Arch. Neurol. doi: 10.1001/archneur.60.9.1202 – volume: 53 start-page: 303 issue: 1 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0445 article-title: Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition publication-title: Neuroimage doi: 10.1016/j.neuroimage.2010.06.016 – volume: 21 start-page: 848 year: 2004 ident: 10.1016/j.nicl.2019.101777_bb0480 article-title: Why am I unsure? Internal and external attributions of uncertainty dissociated by fMRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2003.10.028 – volume: 22 start-page: 670 year: 2012 ident: 10.1016/j.nicl.2019.101777_bb0435 article-title: As time goes by: hippocampal connectivity changes with remoteness of autobiographical memory retrieval publication-title: Hippocampus doi: 10.1002/hipo.20927 – volume: 3 start-page: 255 year: 2003 ident: 10.1016/j.nicl.2019.101777_bb0485 article-title: Neuroimaging studies of working memory publication-title: Cogn. Affect. Behav. Neurosci. doi: 10.3758/CABN.3.4.255 – volume: 70 start-page: 183 year: 2011 ident: 10.1016/j.nicl.2019.101777_bb0175 article-title: Cognitively preserved subjects with transitional cerebrospinal fluid ss-amyloid 1-42 values have thicker cortex in Alzheimer's disease vulnerable areas publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2011.02.017 – year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0010 – volume: 101 start-page: 364 year: 2014 ident: 10.1016/j.nicl.2019.101777_bb0420 article-title: Superficial amygdala and hippocampal activity during affective music listening at 3 T but not 1.5 T fMRI publication-title: NeuroImage doi: 10.1016/j.neuroimage.2014.07.007 – volume: 6 year: 2017 ident: 10.1016/j.nicl.2019.101777_bb0290 article-title: Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline publication-title: eLife doi: 10.7554/eLife.22978 – volume: 25 start-page: 1325 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb2000 article-title: A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data publication-title: NeuroImage doi: 10.1016/j.neuroimage.2004.12.034 – volume: 26 start-page: 331 issue: 4 year: 2004 ident: 10.1016/j.nicl.2019.101777_bb0090 article-title: Calculating status with negative relations publication-title: Soc. Networks doi: 10.1016/j.socnet.2004.08.007 – volume: 22 start-page: 294 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0370 article-title: Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@ T (memory alteration test) in the primary care population publication-title: Int. J. Geriatric Psychiatry doi: 10.1002/gps.1672 – volume: 14 start-page: 1037 year: 2015 ident: 10.1016/j.nicl.2019.101777_bb0460 article-title: Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection publication-title: Lancet Neurol. doi: 10.1016/S1474-4422(15)00093-9 – volume: 9 start-page: 648 year: 1997 ident: 10.1016/j.nicl.2019.101777_bb0415 article-title: Common blood flow changes across visual tasks, II: decreases in cerebral cortex publication-title: J. Cogn. Neurosci. doi: 10.1162/jocn.1997.9.5.648 – volume: 36 start-page: 2687 year: 2015 ident: 10.1016/j.nicl.2019.101777_bb0195 article-title: Nonlinear cerebral atrophy patterns across the Alzheimer's disease continuum: impact of APOE4 genotype publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2015.06.027 – volume: 35 start-page: 3485 year: 2014 ident: 10.1016/j.nicl.2019.101777_bb0270 article-title: Functional centrality of amygdala, striatum and hypothalamus in a “small-world” network underlying joy: An fMRI study with music publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.22416 – volume: 7 start-page: 280 year: 2011 ident: 10.1016/j.nicl.2019.101777_bb0440 article-title: Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease publication-title: Alzheimers Dement. doi: 10.1016/j.jalz.2011.03.003 – volume: 114 start-page: E3368 issue: 17 year: 2017 ident: 10.1016/j.nicl.2019.101777_bb0100 article-title: Controversy in statistical analysis of functional magnetic resonance imaging data publication-title: PNAS doi: 10.1073/pnas.1705513114 – volume: 129 start-page: 564 year: 2006 ident: 10.1016/j.nicl.2019.101777_bb0110 article-title: The precuneus: a review of its functional anatomy and behavioural correlates publication-title: Brain doi: 10.1093/brain/awl004 – volume: 34 start-page: 1515 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0325 article-title: Neural substrates of the self-memory system: new insights from a meta-analysis publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.22008 – volume: 141 year: 2018 ident: 10.1016/j.nicl.2019.101777_bb0425 article-title: The crus exhibits stronger functional connectivity with executive network nodes than with the default mode network publication-title: Brain doi: 10.1093/brain/awy025 – volume: 51 start-page: 266 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0205 article-title: The free and cued selective reminding test: evidence of psychometric adequacy publication-title: Psychol. Sci. Q. – volume: 2 start-page: 265 issue: 5 year: 2012 ident: 10.1016/j.nicl.2019.101777_bb0500 article-title: Fast eigenvector centrality mapping of voxel-wise connectivity in functional magnetic resonance imaging: implementation, validation, and interpretation publication-title: Brain Connectivity doi: 10.1089/brain.2012.0087 – volume: 2 start-page: 30 issue: 9 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb0450 article-title: About a peculiar disease of the cerebral cortex: Alzheimer's original case revisited publication-title: Psychiatry (Edgmont) – volume: 17 start-page: 177 issue: 3 year: 2008 ident: 10.1016/j.nicl.2019.101777_bb0380 article-title: Neurocognitive aging and the compensation hypothesis publication-title: Curr. Dir. Psychol. Sci. doi: 10.1111/j.1467-8721.2008.00570.x – volume: 2 start-page: 685 year: 2001 ident: 10.1016/j.nicl.2019.101777_bb0215 article-title: Searching for a baseline: functional imaging and the resting human brain publication-title: Nat. Rev. Neurosci. doi: 10.1038/35094500 – volume: 24 start-page: 937 year: 2005 ident: 10.1016/j.nicl.2019.101777_bb0225 article-title: Cerebral mechanisms of prosodic integration: evidence from connected speech publication-title: Neuroimage doi: 10.1016/j.neuroimage.2004.11.003 – year: 2000 ident: 10.1016/j.nicl.2019.101777_bb0305 – volume: 31 start-page: 193 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0180 article-title: Addressing a systematic vibration artifact in diffusion-weighted MRI publication-title: Hum. Brain Mapp. doi: 10.1002/hbm.20856 – volume: 69 start-page: 631 year: 2007 ident: 10.1016/j.nicl.2019.101777_bb0300 article-title: CSF tau/Aβ42 ratio for increased risk of mild cognitive impairment a follow-up study publication-title: Neurology doi: 10.1212/01.wnl.0000267428.62582.aa – volume: 33 start-page: 2018 year: 2012 ident: 10.1016/j.nicl.2019.101777_bb0065 article-title: Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment publication-title: Neurobiol. Aging doi: 10.1016/j.neurobiolaging.2011.07.003 – volume: 74 start-page: 340 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0410 article-title: Resting state functional connectivity in preclinical Alzheimer's disease publication-title: Biol. Psychiatry doi: 10.1016/j.biopsych.2012.11.028 – volume: 26 start-page: 695 year: 2016 ident: 10.1016/j.nicl.2019.101777_bb0145 article-title: Effects of beta-amyloid on resting state functional connectivity within and between networks reflect known patterns of regional vulnerability publication-title: Cereb. Cortex – volume: 65 start-page: 550 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0020 article-title: Functional-anatomic fractionation of the brain's default network publication-title: Neuron doi: 10.1016/j.neuron.2010.02.005 – volume: 98 start-page: 676 year: 2001 ident: 10.1016/j.nicl.2019.101777_bb0365 article-title: A default mode of brain function publication-title: PNAS doi: 10.1073/pnas.98.2.676 – volume: 81 start-page: 1732 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0245 article-title: Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity publication-title: Neurology doi: 10.1212/01.wnl.0000435556.21319.e4 – volume: 36 start-page: 67 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0340 article-title: The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study publication-title: J. Alzheimers Dis. doi: 10.3233/JAD-130203 – volume: 2 start-page: 1 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0030 article-title: Advanced normalization tools (ANTS) publication-title: Insight – volume: 49 start-page: 2457 year: 2010 ident: 10.1016/j.nicl.2019.101777_bb0040 article-title: The optimal template effect in hippocampus studies of diseased populations publication-title: Neuroimage doi: 10.1016/j.neuroimage.2009.09.062 – volume: 82 start-page: 240 year: 2011 ident: 10.1016/j.nicl.2019.101777_bb0125 article-title: Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementias publication-title: J. Neurol. Neurosurg. Psychiatry doi: 10.1136/jnnp.2010.207183 – volume: 17 start-page: 502 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0060 article-title: Efficiency, capacity, compensation, maintenance, plasticity: emerging concepts in cognitive reserve publication-title: Trends Cogn. Sci. doi: 10.1016/j.tics.2013.08.012 – year: 2008 ident: 10.1016/j.nicl.2019.101777_bb0310 – volume: 4 start-page: 176 year: 1972 ident: 10.1016/j.nicl.2019.101777_bb0080 article-title: Technique for analyzing overlapping memberships publication-title: Sociol. Methodol. doi: 10.2307/270732 – year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0475 – volume: 29 start-page: 1860 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0105 article-title: Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.5062-08.2009 – volume: 8 start-page: 739 year: 1997 ident: 10.1016/j.nicl.2019.101777_bb0185 article-title: Mental navigation along memorized routes activates the hippocampus, precuneus, and insula publication-title: Neuroreport doi: 10.1097/00001756-199702100-00032 – volume: 3 start-page: 13 year: 1987 ident: 10.1016/j.nicl.2019.101777_bb0200 article-title: Genuine memory deficits in dementia publication-title: Dev. Neuropsychol. doi: 10.1080/87565648709540361 – volume: 37 start-page: 753 year: 2013 ident: 10.1016/j.nicl.2019.101777_bb0250 article-title: Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2013.03.009 – volume: 19 start-page: 497 year: 2009 ident: 10.1016/j.nicl.2019.101777_bb0130 article-title: The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in in asymptomatic amyloid-positive individuals publication-title: Cereb. Cortex doi: 10.1093/cercor/bhn113 – volume: 57 start-page: 1115 year: 2000 ident: 10.1016/j.nicl.2019.101777_bb0135 article-title: Magnetic resonance imaging volumes of the hippocampus and the amygdala in women with borderline personality disorder and early traumatization publication-title: Arch. Gen. Psychiatry doi: 10.1001/archpsyc.57.12.1115 |
| SSID | ssj0000800766 |
| Score | 2.3226388 |
| Snippet | Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating functional... AbstractBackgroundMechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating... • BA39-BA19 centrality implicated in Alzheimer's disease. • Increasing centrality in cingulate and thalamus involved in functional compensation. • Preclinical... Background: Mechanisms of functional compensation throughout the progression of Alzheimer's disease (AD) remain largely underspecified. By investigating... |
| SourceID | doaj pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 101777 |
| SubjectTerms | Aged Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnostic imaging Alzheimer Disease - physiopathology Amyloid beta-Peptides - cerebrospinal fluid Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - physiopathology Connectome - methods Disease Progression Eigenvector centrality Female Functional connectomics Hippocampus Hippocampus - diagnostic imaging Hippocampus - physiopathology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging Male Middle Aged Neural capacity Peptide Fragments - cerebrospinal fluid Prodromal Symptoms Radiology Regular Resting-state fMRI tau Proteins - cerebrospinal fluid |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4k14yUjcaEQc25vkWBBVhbRcoFJvlh-zNFU3WzW7SHDiT3Dg7_FLmHGc1QZQuXDddWKNZzLzjT3zmbEXDtMtraXKFxJUrma1yp1wkC-KWintwDaRjmH-fnZ0rN6d6JOdq76oJmygBx4W7hWGM--1LEMhHb5WWBmUBvCuDBSMovfFmLeTTJ0lHFTFg8qyFDIXui5Tx8xQ3EWss1TX1USeoaqaRKVI3j8JTn-Cz99rKHeC0uEtdjOhSX4wSHGbXYPuDrs-T-fld9n3OVBnb9sve75acApiw94fp1JyzGCjXvZ5oK509MoQuPvCgRg6P8ftfJ4mRqzOl5a4HD7tcxuF4AgdOV1ovIq7I6MT5VT83nabzZJmPDj_egrtEi5_fvvR83QadI8dH779-OYoTxcx5F5Xap0HjXmOqIMOvtB14VBq56D01mL8t4uZrR2C9FBYAKlnoBvtlfXWSaW1rSTI-2yvW3XwkHHUSqlsqITVmJtoGiqsL0E0ntjnmoyJURHGJ5Zyuizj3IzlaGeGlGdIeWZQXsZebp-5GDg6rhz9mvS7HUn82vEHtDqTrM78y-oyJkfrMGMLKzpdfFF75dTV356CPvmN3gjTl6YwH8hqyWgRXlNtgM7Y89EEDX7_dKhjO1hteoNDak0daUXGHgwmuRVNEukrOlmcd2KsE9mn_3TtaeQYR6BKmf-j_7FYj9kNWoRh4-oJ21tfbuApQrm1exa_2l9Z-0ix priority: 102 providerName: Directory of Open Access Journals |
| Title | Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer’s disease |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S2213158219301275 https://www.clinicalkey.es/playcontent/1-s2.0-S2213158219301275 https://www.ncbi.nlm.nih.gov/pubmed/30913531 https://www.proquest.com/docview/2198565460 https://pubmed.ncbi.nlm.nih.gov/PMC6434094 https://doaj.org/article/910cc532d03b4251a3d45eecb2d24062 |
| Volume | 22 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELZKkRAXxH_DT2UkbjQoie1NckCoIKoKabnASr1ZtjPbptpNYLOLKCdeggOvx5Mw4zgLC6seuCZOnMmM7W_G428Ye2rR3VJKyHgqQMZyVMjYphbiaVJIqSyY0tMxjN-Njify7Yk62WFDuaPwA7utrh3Vk5osZs-_fLp4iQP-xe9cLSKRpTSt0tMG5fkVdhVXppwqGowD3D8P6Cj325dZloo4VUUWztFsf83GWuUp_TeWrH8h6d-ZlX8sVUc32Y2AMflhbxS32A40t9m1cdhFv8O-j4HO-9bdvOPtlNPS1kcEOSWYo1_rtXXAKzqrjnM1VNxecCDezs8-yM9Dx4jg-dwQw8PpATdeCI6AklOZ49bHTIaplVNKfN2sVnPq8XD29QzqOSx-fvvR8bBHdJdNjt58eH0ch_IMsVO5XMaVQu8nLSpVuUQViUWprYXMGYP_3kxHprAI3avEAAg1AlUqJ40zVkilTC5A3GO7TdvAHuOolUyaKk-NQo9FUdPUuAzS0hEnXRmxdFCEdoG7nEpozPSQpHauSXmalKd75UXs2fqZjz1zx6WtX5F-1y2JddtfaBenOgxijdDKOSVQJmHRxFMjKqkAnM0qAkZZxMRgHXo42IpTMb6ovrTrfNtT0A2DQae6y3Si35PVktEi6KaMARWxJ4MJapwVaKvHNNCuOo1NCkXn1JKI3e9Nci2aICpYnHqx3w1j3ZB9805Tn3nmcYSvFA948N9f_JBdJ8n7GNYjtrtcrOAxorql3ffRkH0_YH8BTxxOnA |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanisms+of+functional+compensation%2C+delineated+by+eigenvector+centrality+mapping%2C+across+the+pathophysiological+continuum+of+Alzheimer%E2%80%99s+disease&rft.jtitle=NeuroImage+clinical&rft.au=Skouras%2C+Stavros&rft.au=Falcon%2C+Carles&rft.au=Tucholka%2C+Alan&rft.au=Rami%2C+Lorena&rft.date=2019-01-01&rft.issn=2213-1582&rft.eissn=2213-1582&rft.volume=22&rft.spage=101777&rft.epage=101777&rft_id=info:doi/10.1016%2Fj.nicl.2019.101777&rft.externalDBID=ECK1-s2.0-S2213158219301275&rft.externalDocID=1_s2_0_S2213158219301275 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F22131582%2FS2213158219X00029%2Fcov150h.gif |