Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma

• Published in: Cancer cell international Vol. 20; no. 1; pp. 1 - 577
• Main Authors: Zhu, Naiqiang, Hou, Jingyi
• Format: Journal Article
• Language: English
• Published: London BioMed Central 02.12.2020; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Algorithms; Cancer therapies; CD8 antigen; Chemokines; Chemotherapy; Dendritic cells; Gene expression; Genomes; Genomics; Immune infiltration; Immunotherapy; Infiltration; Lymphocytes; Lymphocytes T; Macrophages; Medical prognosis; Mesenchyme; Metastases; Molecular modelling; Primary Research; Prognosis; Proteins; Radiation therapy; Sarcoma; Sarcomas; Signal transduction; Surgery; Survival analysis; Tumor microenvironment; Tumors; Weighted gene co-expression analysis

Abstract Background Sarcomas, cancers originating from mesenchymal cells, are comprehensive tumors with poor prognoses, yet their tumorigenic mechanisms are largely unknown. In this study, we characterize infiltrating immune cells and analyze immune scores to identify the molecular mechanism of immu...