Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 91; no. 20; pp. 9441 - 9445
• Main Authors: Bucala, R, Makita, Z, Vega, G, Grundy, S, Koschinsky, T, Cerami, A, Vlassara, H
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences of the United States of America 27.09.1994; National Acad Sciences; National Academy of Sciences
• Subjects: Animals; Blood plasma; CHIMIORECEPTEUR; Cholesterol - blood; Chronic kidney failure; DIABETE; DIABETES; Diabetes complications; Diabetes mellitus; Diabetes Mellitus - blood; Diabetic Nephropathies - blood; ENFERMEDADES RENALES; Enzyme-Linked Immunosorbent Assay; GENERO HUMANO; GENRE HUMAIN; GLUCOSA; GLUCOSE; Glycated Hemoglobin A - analysis; Glycation End Products, Advanced - blood; Guanidines - therapeutic use; Humans; Kidney Failure, Chronic - blood; Kidneys; LDL receptors; Lipids; LIPOPROTEINAS; LIPOPROTEINE; Lipoproteins; Lipoproteins - blood; Medical disorders; Medical research; Metabolic Clearance Rate; METABOLISME DES LIPIDES; METABOLISMO DE LIPIDOS; Mice; Mice, Transgenic; NEPHROPATHIE; PEPTIDE; PEPTIDOS; PROTEINAS SANGUINEAS; PROTEINE SANGUINE; Proteins; QUIMIORECEPTORS; REACCIONES QUIMICAS; REACTION CHIMIQUE; Receptors, LDL - biosynthesis; Receptors, LDL - genetics; Receptors, LDL - metabolism; Reference Values; Renal insufficiency; Transgenic animals; TRASTORNOS DE PROTEINAS SANGUINEAS; TRASTORNOS METABOLICOS; Triglycerides - blood; TROUBLE DES PROTEINES SANGUINES; TROUBLE DU METABOLISME

Atherosclerosis develops rapidly in patients with diabetes or renal insufficiency. Plasma lipoprotein profiles are frequently abnormal in these conditions and reflect an elevation in the level of the apoprotein B (ApoB)-containing components very low density lipoprotein (VLDL) and low density lipopr...