Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription

• Published in: Journal of Hepatology Vol. 76; no. 1; pp. 135 - 147
• Main Authors: Chen, Qinjunjie, Wang, Haibo, Li, Zheng, Li, Fengwei, Liang, Leilei, Zou, Yiran, Shen, Hao, Li, Jun, Xia, Yong, Cheng, Zhangjun, Yang, Tian, Wang, Kui, Shen, Feng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2022; Elsevier BV; Elsevier Science Ltd
• Subjects: Actinin; Actinin - adverse effects; Aged; Carcinogenesis; Carcinogenesis - genetics; Cholangiocarcinoma; Cholangiocarcinoma - etiology; Cholangiocarcinoma - genetics; Chromatin; circACTN4; Circular RNA; Disease Progression; DNA microarrays; Electrophoretic mobility; Female; Frizzled protein; Frizzled Receptors; Frizzled Receptors - drug effects; Frizzled Receptors - metabolism; FZD7; Hippo; Humans; Immunoprecipitation; Intrahepatic cholangiocarcinoma; Liver cancer; Male; Mass spectroscopy; Metastases; Metastasis; Middle Aged; miRNA; Prognosis; Proportional Hazards Models; Protein purification; Proteins; Ribonucleic acid; RNA; RNA, Circular; RNA, Circular - adverse effects; RNA-binding protein; Statistics, Nonparametric; Therapeutic targets; Transcription; Tumors; Wnt; Wnt protein; Wnt Signaling Pathway; Wnt Signaling Pathway - drug effects; Xenografts; Y-Box-Binding Protein 1; Y-Box-Binding Protein 1 - adverse effects; Y-Box-Binding Protein 1 - drug effects; YAP1; Yes-associated protein; β-Catenin; YAP1; Wnt; circACTN4; FZD7; Hippo; Intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in ICC carcinogenesis and progression remains to be determined. CircRNA microarray was performed to screen significantly upregulated circRNAs in...