Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation

• Published in: Nature communications Vol. 12; no. 1; pp. 1132 - 16
• Main Authors: Lutz, Pierre-Eric, Chay, Marc-Aurèle, Pacis, Alain, Chen, Gary G., Aouabed, Zahia, Maffioletti, Elisabetta, Théroux, Jean-François, Grenier, Jean-Christophe, Yang, Jennie, Aguirre, Maria, Ernst, Carl, Redensek, Adriana, van Kempen, Léon C., Yalcin, Ipek, Kwan, Tony, Mechawar, Naguib, Pastinen, Tomi, Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 45/15; 45/23; 45/91; 631/1647/2210/2211; 631/337/100/2286; 631/337/176/1988; 631/378/1689; 631/378/2584; Amygdala; Amygdala - pathology; Brain; Child; Child Abuse; Child abuse & neglect; Chromatin; Chromatin - metabolism; Context; Crosstalk; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - genetics; Early experience; Epigenetics; Epigenome - genetics; Gene expression; Gene Expression Profiling; Gene Ontology; Genome, Human; Genomes; Genomics; Histone Code; Histones; Histones - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Life Sciences; Monomeric GTP-Binding Proteins - metabolism; multidisciplinary; Protein Processing, Post-Translational; Psychopathology; Science; Science (multidisciplinary); Transcriptomes

Early-life adversity (ELA) is a major predictor of psychopathology, and is thought to increase lifetime risk by epigenetically regulating the genome. Here, focusing on the lateral amygdala, a major brain site for emotional homeostasis, we describe molecular cross-talk among multiple mechanisms of ge...