Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease
Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related chang...
Saved in:
| Published in | Brain research Vol. 1247; pp. 171 - 177 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier B.V
09.01.2009
Elsevier |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease. |
|---|---|
| AbstractList | Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease.Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease. Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease. Abstract Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease. Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in the human brain that include those damaged in motor neuron disease. In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. We then assessed whether or not the expression of collagen XVII was altered in relation to the p62 immunoreactive lesions. We found that neuronal collagen XVII expression in motor neuron disease remains similar to that seen in the normal human brain and thus a change in collagen XVII expression is not an immunohistochemically detectable feature of motor neuron disease. We also found that the regional distribution of p62 varied according to clinical presentation: p62 immunoreactive inclusions were found in the frontal cortex, hippocampus and cerebellum only in subjects with a history of psychiatric morbidity. Our study supports the re-definition of motor neuron disease as a multisystem disorder with a wide clinicopathological spectrum, and we advocate addressing psychiatric symptomology in future studies of motor neuron disease. degeneration with ubiquitinated inclusions and amyotrophic lateral sclerosis, IHC, immunohistochemistry 43 |
| Author | Hofmann, Silke C. Majamaa, Kari Hartikainen, Päivi Pikkarainen, Maria Alafuzoff, Irina Seppänen, Allan |
| Author_xml | – sequence: 1 givenname: Allan surname: Seppänen fullname: Seppänen, Allan organization: Department of Clinical Medicine, Neurology, University of Kuopio, FIN-70211 Kuopio, Finland – sequence: 2 givenname: Maria surname: Pikkarainen fullname: Pikkarainen, Maria organization: Department of Clinical Medicine, Neurology, University of Kuopio, FIN-70211 Kuopio, Finland – sequence: 3 givenname: Päivi surname: Hartikainen fullname: Hartikainen, Päivi organization: Department of Neurology, Kuopio University Hospital, Finland – sequence: 4 givenname: Silke C. surname: Hofmann fullname: Hofmann, Silke C. organization: Department of Dermatology, University Medical Center Freiburg, Germany – sequence: 5 givenname: Kari surname: Majamaa fullname: Majamaa, Kari organization: Department of Neurology, University of Turku, Finland – sequence: 6 givenname: Irina surname: Alafuzoff fullname: Alafuzoff, Irina email: irina.alafuzoff@uku.fi organization: Department of Clinical Medicine, Neurology, University of Kuopio, FIN-70211 Kuopio, Finland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21093252$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18992722$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125862$$DView record from Swedish Publication Index |
| BookMark | eNqNkkFv1DAQhS1URLeFv1DlAiey2E5iJxJCrdoCK1XiUKi4WY49Wc2Stbd2AvTf19Fu99ADy2nk0TdP8_zmhBw574CQM0bnjDLxYTVvg0YXIM45pXVqzimnL8iM1ZLngpf0iMwopSKvm6Y4JicxrtKzKBr6ihyz1OSS8xn5cf13k0Qiepf5LjO-7_USXPbzbrHItLPZ2OL9iAO6vEVn0S2zTfADoMs2gmeprP3gQ-ZgDEnCYgQd4TV52ek-wptdPSW3n6-_X37Nb759WVxe3OSmkuWQa4CylLKoqLQNk0aYWra1kMwaaUpbVKKypZFd15Vda4S2jJXMGNEBFJUsTsn7rWr8A5uxVZuAax0elNeorvDuQvmwVOOoGK9qwRP-bosnA_cjxEGtMRpIhh34MSohZCE5qw6CnPJSNOUEnu3AsV2D3S_w9L0JeLsDdDS674J2BuOe44w2Ba8m7uOWM8HHGKBTBgc9pFCGlHKvGFVT6mqlnlJXU-pTP6WexsWz8f0mhwbPt4OQQvqNEFQ0CM6AxQBmUNbjYYlPzyRMjw6T21_wAHHlx-DSCSimIldU3U43OZ0krSmvJv__FPifDR4B-4v0pg |
| CODEN | BRREAP |
| CitedBy_id | crossref_primary_10_1007_s00401_024_02722_0 crossref_primary_10_1038_s41467_020_18949_w crossref_primary_10_1002_mco2_638 crossref_primary_10_1016_j_neurobiolaging_2012_06_021 crossref_primary_10_1016_j_mbplus_2021_100089 crossref_primary_10_3109_21678421_2013_812661 |
| Cites_doi | 10.1111/j.1365-2990.2007.00884.x 10.1007/s00401-006-0127-z 10.1016/j.bbadis.2006.09.003 10.1016/0022-510X(90)90038-O 10.1007/s00403-006-0690-0 10.1111/j.1750-3639.2008.00147.x 10.1016/S0022-510X(98)00223-8 10.1212/WNL.36.7.948 10.1097/NEN.0b013e31816a1da2 10.1111/j.1440-1789.2004.00572.x 10.1016/0022-510X(94)90094-9 10.1074/jbc.R400034200 10.1016/S0140-6736(96)90737-0 10.1001/archderm.136.4.521 10.1007/s00401-008-0402-2 10.1093/brain/awm024 10.1016/S0304-3940(03)00216-7 10.1212/WNL.42.8.1535 10.1016/j.matbio.2005.11.004 10.1016/j.jns.2006.05.060 10.1016/j.brainres.2007.04.073 10.1212/01.wnl.0000231510.89311.8b 10.1001/archneur.65.5.636 10.1007/s00401-007-0234-5 |
| ContentType | Journal Article |
| Copyright | 2008 Elsevier B.V. Elsevier B.V. 2009 INIST-CNRS |
| Copyright_xml | – notice: 2008 Elsevier B.V. – notice: Elsevier B.V. – notice: 2009 INIST-CNRS |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7TK 7X8 ADTPV AOWAS DF2 |
| DOI | 10.1016/j.brainres.2008.10.020 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts MEDLINE - Academic SwePub SwePub Articles SWEPUB Uppsala universitet |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Neurosciences Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Neurosciences Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Medicine |
| EISSN | 1872-6240 |
| EndPage | 177 |
| ExternalDocumentID | oai_DiVA_org_uu_125862 18992722 21093252 10_1016_j_brainres_2008_10_020 S0006899308025109 1_s2_0_S0006899308025109 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M -DZ -~X .1- .FO .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXLA AAXUO AAYWO ABCQJ ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABTEW ABWVN ABXDB ACDAQ ACGFO ACGFS ACIUM ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFPUW AFRHN AFTJW AFXIZ AGCQF AGUBO AGWIK AGYEJ AHHHB AIEXJ AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q HZ~ IHE J1W K-O KOM L7B M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OP~ OZT P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SES SPCBC SSN SSZ T5K Z5R ZGI ~G- .55 .GJ 41~ AACTN AAQXK AAYJJ ADIYS AFCTW AFJKZ AFKWA AGHFR AI. AJOXV AMFUW ASPBG AVWKF AZFZN FEDTE FGOYB G-2 GBLVA HMQ HVGLF MVM P-8 PKN R2- RIG SEW SNS VH1 WUQ X7M XPP AADPK AAIAV ABYKQ AJBFU EFLBG AAYXX AGQPQ AGRNS AIGII APXCP BNPGV CITATION SSH IQODW CGR CUY CVF ECM EIF NPM 7TK 7X8 ADTPV AOWAS DF2 |
| ID | FETCH-LOGICAL-c574t-aee44773507d917c6c87b8671dc7c4d3565d4c7fff4fbc6ad1141cc6fee3573 |
| IEDL.DBID | AIKHN |
| ISSN | 0006-8993 1872-6240 |
| IngestDate | Thu Aug 21 06:36:46 EDT 2025 Fri Jul 11 06:28:42 EDT 2025 Tue Aug 05 10:57:15 EDT 2025 Tue Aug 05 11:35:06 EDT 2025 Mon Jul 21 09:16:57 EDT 2025 Tue Jul 01 01:21:13 EDT 2025 Thu Apr 24 23:08:59 EDT 2025 Fri Feb 23 02:28:24 EST 2024 Sun Feb 23 10:19:39 EST 2025 Tue Aug 26 16:31:49 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | coll XVII MND NCI PMA Collagen XVII NT TDP-43 Motor neuron disease ALS CNS IR p62 motor neuron disease neuronal cytoplasmic inclusions progressive muscular atrophy amyotrophic lateral sclerosis central nervous system immunoreactive trans-activating responsive sequence DNA-binding protein 43 neurites ubiquitin-binding protein p62/sequestosome 1 collagen XVII, FTLD-U/ALS, frontotemporal lobar degeneration with ubiquitinated inclusions and amyotrophic lateral sclerosis, IHC, immunohistochemistry Human Ubiquitin Nervous system diseases Glycoprotein Gene expression Binding protein Collagen Central nervous system disease Degenerative disease Spinal cord disease |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c574t-aee44773507d917c6c87b8671dc7c4d3565d4c7fff4fbc6ad1141cc6fee3573 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 18992722 |
| PQID | 20246945 |
| PQPubID | 23462 |
| PageCount | 7 |
| ParticipantIDs | swepub_primary_oai_DiVA_org_uu_125862 proquest_miscellaneous_66737215 proquest_miscellaneous_20246945 pubmed_primary_18992722 pascalfrancis_primary_21093252 crossref_citationtrail_10_1016_j_brainres_2008_10_020 crossref_primary_10_1016_j_brainres_2008_10_020 elsevier_sciencedirect_doi_10_1016_j_brainres_2008_10_020 elsevier_clinicalkeyesjournals_1_s2_0_S0006899308025109 elsevier_clinicalkey_doi_10_1016_j_brainres_2008_10_020 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2009-01-09 |
| PublicationDateYYYYMMDD | 2009-01-09 |
| PublicationDate_xml | – month: 01 year: 2009 text: 2009-01-09 day: 09 |
| PublicationDecade | 2000 |
| PublicationPlace | Amsterdam |
| PublicationPlace_xml | – name: Amsterdam – name: Netherlands |
| PublicationTitle | Brain research |
| PublicationTitleAlternate | Brain Res |
| PublicationYear | 2009 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Dickson, Josephs, Amador-Ortiz (bib6) 2007; 114 Furukawa, Iseki, Hino, Odawara, Ikeda, Tsuchiya, Kosaka (bib8) 2004; 24 Hiji, Takahashi, Fukuba, Yamashita, Kohriyama, Matsumoto (bib10) 2008; 116 Seppänen, Suuronen, Hofmann, Majamaa, Alafuzoff (bib27) 2007; 1158 Ono, Yamauchi (bib16) 1992; 42 Ono, Toyokura, Mannen, Ishibashi (bib17) 1986; 36 Braak, Alafuzoff, Arzberger, Kretzschmar, Del-Tredici (bib3) 2006; 112 Seelaar, Schelhaas, Azmani, Küsters, Rosso, Majoor-Krakauer, de Rijik, Rizzu, ten Brummelhuis, van Doorn, Kamphorst, Willemsen, van Swieten (bib25) 2007; 130 Mizuno, Amari, Takatama, Aizawa, Mihara, Okamoto (bib15) 2006; 249 Schmidt, Wehr, Wolf, Sitaru, Bröcker, Zillikens (bib23) 2006; 298 Provinciali, Cangiotti, Tulli, Carboni, Cinti (bib22) 1994; 126 Charcot, J.M., 1880. Lecon sur le maladies du systeme nerveux faites a ala Salpetriere. Paris, France, Vol II. Arai, Nonaka, Hasegawa, Akiyama, Yoshida, Hashizume, Tsuchiya, Oda, Ikeda (bib2) 2003; 15 Seppänen, Autio-Harmainen, Alafuzoff, Särkioja, Veijola, Hurskainen, Bruckner-Tuderman, Tasanen, Majamaa (bib26) 2006; 25 Parkinson, Ince, Smith, Highley, Skibinski, Andersen, Morrison, Pall, Hardiman, Collinge, Shaw, Fisher (bib20) 2006; 67 Xiao, McLean, Robertson (bib29) 2006; 1762 Ono, Mechanic, Yamauchi (bib18) 1990; 100 Alafuzoff, I., Arzberger, T., Al-Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del-Tredici, K., Ferrer, I., Gelpi, E., Giaccone, G., Graeber, M.B., Ince, P., Kamphorst, W., King, A., Korkolopoulou, P., Kovács, G.G., Larionov, S., Meyronet, D., Monoranu, C., Parchi, P., Patsouris, E., Roggendorf, W., Seilhean, D., Tagliavini, F., Stadelmann, C., Streichenberger, N., Thal, D.R., Wharton, S.B., Kretzschmar, H., in press. Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium. Brain Pathol. Franzke, Bruckner, Bruckner-Tuderman (bib7) 2005; 280 Ono, Imai, Munakata, Takahashi, Kanda, Hashimoto, Yamano, Shimizu, Nagao, Yamauchi (bib19) 1998; 160 Kolde, Bachus, Ludolph (bib12) 1996; 4 Pikkarainen, Hartikainen, Alafuzoff (bib21) 2008; 67 Chosidow, Doppler, Bensimon, Joly, Salachas, Lacomblez, Prost, Camu, Frances, Herson, Meininger (bib5) 2000; 136 Kuusisto, Kauppinen, Alafuzoff (bib14) 2008; 34 Geser, Brandmeir, Kwong, Martinez-Lage, Elman, McCluskey, Xie, Lee, Trojanowski (bib9) 2008; 65 Mizuno (10.1016/j.brainres.2008.10.020_bib15) 2006; 249 Kolde (10.1016/j.brainres.2008.10.020_bib12) 1996; 4 Xiao (10.1016/j.brainres.2008.10.020_bib29) 2006; 1762 Chosidow (10.1016/j.brainres.2008.10.020_bib5) 2000; 136 Braak (10.1016/j.brainres.2008.10.020_bib3) 2006; 112 Ono (10.1016/j.brainres.2008.10.020_bib16) 1992; 42 Seppänen (10.1016/j.brainres.2008.10.020_bib27) 2007; 1158 Franzke (10.1016/j.brainres.2008.10.020_bib7) 2005; 280 Seppänen (10.1016/j.brainres.2008.10.020_bib26) 2006; 25 Ono (10.1016/j.brainres.2008.10.020_bib18) 1990; 100 Dickson (10.1016/j.brainres.2008.10.020_bib6) 2007; 114 Furukawa (10.1016/j.brainres.2008.10.020_bib8) 2004; 24 Provinciali (10.1016/j.brainres.2008.10.020_bib22) 1994; 126 Ono (10.1016/j.brainres.2008.10.020_bib17) 1986; 36 Parkinson (10.1016/j.brainres.2008.10.020_bib20) 2006; 67 Seelaar (10.1016/j.brainres.2008.10.020_bib25) 2007; 130 Kuusisto (10.1016/j.brainres.2008.10.020_bib14) 2008; 34 Geser (10.1016/j.brainres.2008.10.020_bib9) 2008; 65 10.1016/j.brainres.2008.10.020_bib4 Hiji (10.1016/j.brainres.2008.10.020_bib10) 2008; 116 10.1016/j.brainres.2008.10.020_bib1 Arai (10.1016/j.brainres.2008.10.020_bib2) 2003; 15 Schmidt (10.1016/j.brainres.2008.10.020_bib23) 2006; 298 Ono (10.1016/j.brainres.2008.10.020_bib19) 1998; 160 Pikkarainen (10.1016/j.brainres.2008.10.020_bib21) 2008; 67 |
| References_xml | – volume: 67 start-page: 280 year: 2008 end-page: 298 ident: bib21 article-title: Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry publication-title: J. Neuropathol. Exp. Neurol. – reference: Charcot, J.M., 1880. Lecon sur le maladies du systeme nerveux faites a ala Salpetriere. Paris, France, Vol II. – volume: 24 start-page: 306 year: 2004 end-page: 314 ident: bib8 article-title: Ubiquitin and ubiquitin-related proteins in the brains of patients with atypical Pick's disease without Pick bodies and dementia with motor neuron disease publication-title: Neuropathology – volume: 249 start-page: 13 year: 2006 end-page: 18 ident: bib15 article-title: Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. – volume: 4 start-page: 1226 year: 1996 end-page: 1227 ident: bib12 article-title: Skin involvement in amyotrophic lateral sclerosis publication-title: Lancet – volume: 42 start-page: 1535 year: 1992 end-page: 1539 ident: bib16 article-title: Amyotrophic lateral sclerosis: increased solubility of skin collagen publication-title: Neurology – volume: 36 start-page: 948 year: 1986 end-page: 956 ident: bib17 article-title: Amyotrophic lateral sclerosis: histologic, histochemical, and ultrastructural abnormalities of skin publication-title: Neurology – reference: Alafuzoff, I., Arzberger, T., Al-Sarraj, S., Bodi, I., Bogdanovic, N., Braak, H., Bugiani, O., Del-Tredici, K., Ferrer, I., Gelpi, E., Giaccone, G., Graeber, M.B., Ince, P., Kamphorst, W., King, A., Korkolopoulou, P., Kovács, G.G., Larionov, S., Meyronet, D., Monoranu, C., Parchi, P., Patsouris, E., Roggendorf, W., Seilhean, D., Tagliavini, F., Stadelmann, C., Streichenberger, N., Thal, D.R., Wharton, S.B., Kretzschmar, H., in press. Staging of neurofibrillary pathology in Alzheimer's disease: A study of the BrainNet Europe Consortium. Brain Pathol. – volume: 136 start-page: 521 year: 2000 end-page: 524 ident: bib5 article-title: Bullous pemphigoid and amyotrophic lateral sclerosis a new clue for understanding the bullous disease? publication-title: Arch. Dermatol. – volume: 34 start-page: 169 year: 2008 end-page: 180 ident: bib14 article-title: Use of p62/SQSTM1 antibodies for neuropathological diagnosis publication-title: Neuropathol. Appl. Neurobiol. – volume: 65 start-page: 636 year: 2008 end-page: 641 ident: bib9 article-title: Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis publication-title: Arch. Neurol. – volume: 1158 start-page: 50 year: 2007 end-page: 56 ident: bib27 article-title: Distribution of collagen XVII in the human brain publication-title: Brain Res. – volume: 116 start-page: 183 year: 2008 end-page: 191 ident: bib10 article-title: White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin publication-title: Acta Neuropathol. – volume: 1762 start-page: 1001 year: 2006 end-page: 1012 ident: bib29 article-title: Neuronal intermediate filaments and ALS: a new look at an old question publication-title: Biochim. Biophys. Acta – volume: 130 start-page: 1375 year: 2007 end-page: 1385 ident: bib25 article-title: TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations publication-title: Brain – volume: 67 start-page: 1074 year: 2006 end-page: 1077 ident: bib20 article-title: ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) publication-title: Neurology – volume: 280 start-page: 4005 year: 2005 end-page: 4008 ident: bib7 article-title: Collagenous transmembrane proteins: recent insights into biology and pathology publication-title: J. Biol. Chem. – volume: 114 start-page: 71 year: 2007 end-page: 79 ident: bib6 article-title: TDP-43 in differential diagnosis of motor neuron disorders publication-title: Acta Neuropathol. – volume: 15 start-page: 41 year: 2003 end-page: 44 ident: bib2 article-title: Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62 publication-title: Neurosci. Lett. – volume: 160 start-page: 140 year: 1998 end-page: 147 ident: bib19 article-title: Collagen abnormalities in the spinal cord from patients with amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. – volume: 25 start-page: 185 year: 2006 end-page: 188 ident: bib26 article-title: Collagen XVII is expressed in human CNS neurons publication-title: Mat. Biol. – volume: 112 start-page: 389 year: 2006 end-page: 404 ident: bib3 article-title: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry publication-title: Acta Neuropathol. – volume: 100 start-page: 234 year: 1990 end-page: 237 ident: bib18 article-title: Amyotrophic lateral sclerosis: unusually low content of collagen in skin publication-title: J. Neurol. Sci. – volume: 126 start-page: 54 year: 1994 end-page: 61 ident: bib22 article-title: Skin abnormalities and autonomic involvement in the early stage of amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. – volume: 298 start-page: 283 year: 2006 end-page: 290 ident: bib23 article-title: Localisation of bullous pemphigoid antigen 180 (BP180) in cultured human keratinocytes: functionally relevant modification by calcium publication-title: Arch. Dermatol. Res. – volume: 34 start-page: 169 year: 2008 ident: 10.1016/j.brainres.2008.10.020_bib14 article-title: Use of p62/SQSTM1 antibodies for neuropathological diagnosis publication-title: Neuropathol. Appl. Neurobiol. doi: 10.1111/j.1365-2990.2007.00884.x – volume: 112 start-page: 389 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib3 article-title: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry publication-title: Acta Neuropathol. doi: 10.1007/s00401-006-0127-z – volume: 1762 start-page: 1001 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib29 article-title: Neuronal intermediate filaments and ALS: a new look at an old question publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbadis.2006.09.003 – volume: 100 start-page: 234 year: 1990 ident: 10.1016/j.brainres.2008.10.020_bib18 article-title: Amyotrophic lateral sclerosis: unusually low content of collagen in skin publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(90)90038-O – volume: 298 start-page: 283 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib23 article-title: Localisation of bullous pemphigoid antigen 180 (BP180) in cultured human keratinocytes: functionally relevant modification by calcium publication-title: Arch. Dermatol. Res. doi: 10.1007/s00403-006-0690-0 – ident: 10.1016/j.brainres.2008.10.020_bib1 doi: 10.1111/j.1750-3639.2008.00147.x – volume: 160 start-page: 140 year: 1998 ident: 10.1016/j.brainres.2008.10.020_bib19 article-title: Collagen abnormalities in the spinal cord from patients with amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. doi: 10.1016/S0022-510X(98)00223-8 – volume: 36 start-page: 948 year: 1986 ident: 10.1016/j.brainres.2008.10.020_bib17 article-title: Amyotrophic lateral sclerosis: histologic, histochemical, and ultrastructural abnormalities of skin publication-title: Neurology doi: 10.1212/WNL.36.7.948 – volume: 67 start-page: 280 year: 2008 ident: 10.1016/j.brainres.2008.10.020_bib21 article-title: Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry publication-title: J. Neuropathol. Exp. Neurol. doi: 10.1097/NEN.0b013e31816a1da2 – volume: 24 start-page: 306 year: 2004 ident: 10.1016/j.brainres.2008.10.020_bib8 article-title: Ubiquitin and ubiquitin-related proteins in the brains of patients with atypical Pick's disease without Pick bodies and dementia with motor neuron disease publication-title: Neuropathology doi: 10.1111/j.1440-1789.2004.00572.x – volume: 126 start-page: 54 year: 1994 ident: 10.1016/j.brainres.2008.10.020_bib22 article-title: Skin abnormalities and autonomic involvement in the early stage of amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. doi: 10.1016/0022-510X(94)90094-9 – volume: 280 start-page: 4005 year: 2005 ident: 10.1016/j.brainres.2008.10.020_bib7 article-title: Collagenous transmembrane proteins: recent insights into biology and pathology publication-title: J. Biol. Chem. doi: 10.1074/jbc.R400034200 – volume: 4 start-page: 1226 year: 1996 ident: 10.1016/j.brainres.2008.10.020_bib12 article-title: Skin involvement in amyotrophic lateral sclerosis publication-title: Lancet doi: 10.1016/S0140-6736(96)90737-0 – volume: 136 start-page: 521 year: 2000 ident: 10.1016/j.brainres.2008.10.020_bib5 article-title: Bullous pemphigoid and amyotrophic lateral sclerosis a new clue for understanding the bullous disease? publication-title: Arch. Dermatol. doi: 10.1001/archderm.136.4.521 – volume: 116 start-page: 183 year: 2008 ident: 10.1016/j.brainres.2008.10.020_bib10 article-title: White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin publication-title: Acta Neuropathol. doi: 10.1007/s00401-008-0402-2 – volume: 130 start-page: 1375 issue: Pt 5 year: 2007 ident: 10.1016/j.brainres.2008.10.020_bib25 article-title: TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations publication-title: Brain doi: 10.1093/brain/awm024 – ident: 10.1016/j.brainres.2008.10.020_bib4 – volume: 15 start-page: 41 year: 2003 ident: 10.1016/j.brainres.2008.10.020_bib2 article-title: Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62 publication-title: Neurosci. Lett. doi: 10.1016/S0304-3940(03)00216-7 – volume: 42 start-page: 1535 year: 1992 ident: 10.1016/j.brainres.2008.10.020_bib16 article-title: Amyotrophic lateral sclerosis: increased solubility of skin collagen publication-title: Neurology doi: 10.1212/WNL.42.8.1535 – volume: 25 start-page: 185 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib26 article-title: Collagen XVII is expressed in human CNS neurons publication-title: Mat. Biol. doi: 10.1016/j.matbio.2005.11.004 – volume: 249 start-page: 13 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib15 article-title: Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2006.05.060 – volume: 1158 start-page: 50 year: 2007 ident: 10.1016/j.brainres.2008.10.020_bib27 article-title: Distribution of collagen XVII in the human brain publication-title: Brain Res. doi: 10.1016/j.brainres.2007.04.073 – volume: 67 start-page: 1074 year: 2006 ident: 10.1016/j.brainres.2008.10.020_bib20 article-title: ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) publication-title: Neurology doi: 10.1212/01.wnl.0000231510.89311.8b – volume: 65 start-page: 636 year: 2008 ident: 10.1016/j.brainres.2008.10.020_bib9 article-title: Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis publication-title: Arch. Neurol. doi: 10.1001/archneur.65.5.636 – volume: 114 start-page: 71 year: 2007 ident: 10.1016/j.brainres.2008.10.020_bib6 article-title: TDP-43 in differential diagnosis of motor neuron disorders publication-title: Acta Neuropathol. doi: 10.1007/s00401-007-0234-5 |
| SSID | ssj0003390 |
| Score | 1.951932 |
| Snippet | Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in locations in... Abstract Collagen involvement in motor neuron disease has been suggested by several earlier studies. Recently, we found collagen XVII to be expressed in... |
| SourceID | swepub proquest pubmed pascalfrancis crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 171 |
| SubjectTerms | Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adult Aged Aged, 80 and over Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - physiopathology Autoantigens - genetics Autoantigens - metabolism Biological and medical sciences Biomarkers - analysis Biomarkers - metabolism Brain - metabolism Brain - pathology Brain - physiopathology Cerebellum - metabolism Cerebellum - pathology Cerebellum - physiopathology Cerebrospinal fluid. Meninges. Spinal cord Collagen Type XVII Collagen XVII Comorbidity Cytoskeleton - metabolism Cytoskeleton - pathology Dermatologi och venerologi, klinisk genetik, invärtesmedicin Dermatology and venerology,clinical genetics, internal medicine Female Frontal Lobe - metabolism Frontal Lobe - pathology Frontal Lobe - physiopathology Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Humans Immunohistochemistry Internal medicine Invärtesmedicin Male Medical sciences MEDICIN MEDICINE Middle Aged Morfologi, cellbiologi, patologi Morphology, cell biology, pathology Motor neuron disease Motor Neuron Disease - genetics Motor Neuron Disease - metabolism Motor Neuron Disease - physiopathology Nervous system (semeiology, syndromes) Neurocognitive Disorders - metabolism Neurocognitive Disorders - pathology Neurocognitive Disorders - physiopathology Neurologi Neurology Neurons - metabolism Neurons - pathology Non-Fibrillar Collagens - genetics Non-Fibrillar Collagens - metabolism p62 Pathology Patologi Sequestosome-1 Protein |
| Title | Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0006899308025109 https://www.clinicalkey.es/playcontent/1-s2.0-S0006899308025109 https://dx.doi.org/10.1016/j.brainres.2008.10.020 https://www.ncbi.nlm.nih.gov/pubmed/18992722 https://www.proquest.com/docview/20246945 https://www.proquest.com/docview/66737215 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-125862 |
| Volume | 1247 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lj9MwELb2cUFCCFge5VF8AG7ZJo5jN8eq7KrlsULArnqz4hfKCpzShwQXfjvj2AksLALBqVKaSWv7m_FMPPMNQo9BwVKrpU7yVOuEKjZOZFkZiFLGZTbWkrOWxPXVCZud0ueLYrGDpl0tjE-rjLY_2PTWWscrozibo2Vd-xrflEG0kPtqUUBWuYv2SV4ygPb-ZP5idtIb5DwPr1p88OwFfigUPj-UvhMDRLYhrdInevnW35fvUVeX1RpmzoaWF5f5pD8Rjrab1PF1dC16l3gSBnAD7Rh3Ex1MHETWH7_gp7jN92xfpB-g06PPMQnW4cbiFhCAJrw4m89x5TTeyvrTtt7UzkfPfovDLalD7fCSEQwfsMrNCreMmA7Hk55b6O3x0bvpLIlNFhJVcLpJKmMo5TwHv1BD6KaYGnPpSe-04orqHBw-TRW31lIrFas0BFCZUswakxc8v432XOPMXYSzqkxZSkqleEWJzUoOGJDK2KwqCi7TASq6SRUq8o_7NhgfRJdodi66xQjNMeE6LMYAjXq5ZWDg-KME79ZMdPWlYBEFbBL_JmnWUbHXIhNrIlLxC_gGqOwlL-D3r351eAFY_TCJ5_oiBRmgRx3SBGi_P9KpnGm2_imEspIWv7-DtY2IMrjjToDo90mE_084gac_CZjtv_GU48_qs4loVu_F1rONFxD43vuPId5HV8IxXJak5QO0t1ltzUPw5jZyiHYPv2ZD0Nnpm5evh1F3vwEDvkyn |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZKOYBUIaBAl0frA3BLN3Ece3NclVa70PZCW-3Nil8oFTjL7kaCC7-dsZ1sKRSB4BTJsZPY_saeiWe-QeglCFhqtdRJnmqdUMVGiSwrA1bKqMxGWnIWSFxPTtnknL6dFbMNdNDHwni3ym7tj2t6WK27kmE3msN5XfsY35SBtZD7aFFAVnkL3aYgvl46979d-XnkefzR4k1nX_2HMOHLfenzMIBdG50qvZuXT_x98w61Na-WMG42Jry4SSP9iW40bFFH99G9TrfE4_j5D9CGcQ_R9tiBXf3pK36Ng7dn-I2-jc4Pv3QusA43Fgc4AJbw7GI6xZXTuJX157Ze1c7bzn6Dw4HSoXZ4zgiGC8xxs8CBD9Ph7pznEXp_dHh2MEm6FAuJKjhdJZUxlHKeg1aowXBTTI249JR3WnFFdQ7qnqaKW2uplYpVGsynTClmjckLnj9Gm65xZgfhrCpTlpJSKV5RYrOSAwKkMjarioLLdICKflCF6tjHfRKMj6J3M7sU_WTE1JhQDpMxQMN1u3nk3_hjC97PmeijS2E9FLBF_FtLs-zEeikysSQiFb9Ab4DKdctr6P2rt-5eA9a6m8QzfZGCDNBejzQBsu8PdCpnmtY_hVBW0uL3NVhIQ5RBjScRoleDCN9POIGnv4qYXd_xhONv6ouxaBYfROu5xgswe5_-Rxf30J3J2cmxOJ6evnuG7sYDuSxJy-doc7VozQvQ61ZyN8jtd2ZKS9Y |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Expression+of+collagen+XVII+and+ubiquitin-binding+protein+p62+in+motor+neuron+disease&rft.jtitle=Brain+research&rft.au=Sepp%C3%A4nen%2C+Allan&rft.au=Pikkarainen%2C+Maria&rft.au=Hartikainen%2C+P%C3%A4ivi&rft.au=Hofmann%2C+Silke+C.&rft.date=2009-01-09&rft.issn=0006-8993&rft.volume=1247&rft.spage=171&rft.epage=177&rft_id=info:doi/10.1016%2Fj.brainres.2008.10.020&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_brainres_2008_10_020 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F00068993%2FS0006899308X00575%2Fcov150h.gif |