Bidirectional crosstalk between periventricular endothelial cells and neural progenitor cells promotes the formation of a neurovascular unit

• Published in: Brain research Vol. 1565; pp. 8 - 17
• Main Authors: Vissapragada, Ravi, Contreras, Mauricio A., da Silva, Cleide G, Kumar, Vivek A., Ochoa, Angelica, Vasudevan, Anju, Selim, Magdy H., Ferran, Christiane, Thomas, Ajith J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 27.05.2014; Elsevier
• Subjects: Angiogenesis; Animals; Biological and medical sciences; Cells, Cultured; Cerebral Ventricles - embryology; Differentiation; Endothelial Cells - cytology; Endothelial Cells - metabolism; Fundamental and applied biological sciences. Psychology; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic - physiology; Neural progenitor cell; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; Neurogenesis; Neurology; Neurovascular niche; Periventricular endothelial cell; Proliferation; Vascular endothelial growth factor; Vertebrates: nervous system and sense organs; Periventricular endothelial cell; Neurovascular niche; Angiogenesis; Neural progenitor cell; Proliferation; Differentiation; Neurogenesis; Vascular endothelial growth factor; Cell proliferation; Endothelial cell; Precursor cell; Vascular endothelium growth factor; Progenitor cell

Interactions between neural progenitor cells (NPC) and endothelial cells (EC) from adult vascular beds have been well explored previously. However, the factors and signaling mechanisms that regulate neurogenesis and angiogenesis are most prevalent during embryonic development. This study aimed to de...