Diurnal and seasonal variation of the brain serotonin system in healthy male subjects

• Published in: NeuroImage (Orlando, Fla.) Vol. 112; pp. 225 - 231
• Main Authors: Matheson, Granville J., Schain, Martin, Almeida, Rita, Lundberg, Johan, Cselényi, Zsolt, Borg, Jacqueline, Varrone, Andrea, Farde, Lars, Cervenka, Simon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.05.2015; Elsevier Limited
• Subjects: Adult; Age; Benzylamines; Brain; Brain - diagnostic imaging; Brain Chemistry - drug effects; Brain Chemistry - physiology; Cerebral Cortex - metabolism; Circadian; Circadian rhythm; Circadian Rhythm - physiology; Cohort Studies; Cross-Sectional Studies; Data processing; Depression; Female; Gene expression; Human; Humans; Image Processing, Computer-Assisted; Light; Male; Middle Aged; PET; Physiology; Piperazines - pharmacology; Positron-Emission Tomography; Pyridines - pharmacology; Radiopharmaceuticals; Receptor, Serotonin, 5-HT1A - metabolism; Regression analysis; Seasonal; Seasons; Serotonin; Serotonin - metabolism; Serotonin - physiology; Serotonin Antagonists - pharmacology; Serotonin Plasma Membrane Transport Proteins - metabolism; Studies; Young Adult; Human; Depression; Seasonal; Serotonin; Circadian; PET

The mammalian circadian clock underlies both diurnal and seasonal changes in physiology, and its function is thought to be disturbed in both seasonal and non-seasonal depression. In humans, molecular imaging studies have reported seasonal changes in the serotonin system. Despite the role of the circ...