Rapid emergence of extensively drug-resistant Shigella sonnei in France

• Published in: Nature communications Vol. 14; no. 1; pp. 462 - 10
• Main Authors: Lefèvre, Sophie, Njamkepo, Elisabeth, Feldman, Sarah, Ruckly, Corinne, Carle, Isabelle, Lejay-Collin, Monique, Fabre, Laëtitia, Yassine, Iman, Frézal, Lise, Pardos de la Gandara, Maria, Fontanet, Arnaud, Weill, François-Xavier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.01.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/23; 49; 49/23; 631/326/107; 631/326/1762; 631/326/41/2530; 692/700/478/174; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antiinfectives and antibacterials; Azithromycin; Azithromycin - pharmacology; Azithromycin - therapeutic use; Bacteriology; beta-Lactamases - genetics; Cephalosporins; Chromosomes; Ciprofloxacin; Ciprofloxacin - pharmacology; Decision making; Drug resistance; Drug Resistance, Multiple, Bacterial; Dysentery; Dysentery, Bacillary - drug therapy; Dysentery, Bacillary - epidemiology; Evolutionary genetics; France - epidemiology; Gene sequencing; Genomic analysis; Humanities and Social Sciences; Humans; Laboratories; Life Sciences; Microbial Sensitivity Tests; Microbiology and Parasitology; multidisciplinary; Phenotypes; Plasmids; Plasmids - genetics; Public health; Science; Science (multidisciplinary); Shigella sonnei; Shigella sonnei - drug effects; Shigella sonnei - genetics; Shigellosis; Surveillance; Waterborne diseases; Whole genome sequencing; β Lactamase; France
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-023-36222-8

Shigella sonnei , the main cause of bacillary dysentery in high-income countries, has become increasingly resistant to antibiotics. We monitored the antimicrobial susceptibility of 7121  S. sonnei isolates collected in France between 2005 and 2021. We detected a dramatic increase in the proportion o...