Multiple Genetic Loci for Bone Mineral Density and Fractures

• Published in: The New England journal of medicine Vol. 358; no. 22; pp. 2355 - 2365
• Main Authors: Styrkarsdottir, Unnur, Halldorsson, Bjarni V, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Walters, G. Bragi, Ingvarsson, Thorvaldur, Jonsdottir, Thorbjorg, Saemundsdottir, Jona, Center, Jacqueline R, Nguyen, Tuan V, Bagger, Yu, Gulcher, Jeffrey R, Eisman, John A, Christiansen, Claus, Sigurdsson, Gunnar, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 29.05.2008
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Australia; Biological and medical sciences; Bone density; Bone Density - genetics; Denmark; Estrogen Receptor alpha - genetics; Female; Fractures; Fractures, Bone - genetics; General aspects; Genotype; Humans; Iceland; Investigative techniques, diagnostic techniques (general aspects); Linear Models; Male; Medical sciences; Methods; Middle Aged; Mortality; Older people; Osteoarticular system. Muscles; Osteoporosis; Osteoporosis - genetics; Osteoprotegerin - genetics; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Radiodiagnosis. Nmr imagery. Nmr spectrometry; RANK Ligand - genetics; Denmark; Australia; Iceland; Medicine; Multiple; Diseases of the osteoarticular system; Genetics; Bone mineral density; Fracture; Trauma

This study implicates five genetic loci in bone mineral density. Two of these loci are new; three implicate genes known to be involved in bone remodeling, such as the receptor activator of nuclear factor-κB ligand gene ( RANKL ). Analyses showed that three of the loci are associated with osteoporoti...