Plasmablastic Lymphoma: A Review of Clinicopathologic Features and Differential Diagnosis

Plasmablastic lymphoma (PBL) is a challenging diagnosis given its rarity and lack of expression of markers that are usually used by pathologists in establishing hematopoietic lineage. However, knowledge of the characteristic clinical setting, sites of involvement, and morphologic features of plasmab...

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Bibliographic Details
Published inArchives of pathology & laboratory medicine (1976) Vol. 140; no. 10; pp. 1074 - 1078
Main Authors Harmon, Charles M, Smith, Lauren B
Format Journal Article
LanguageEnglish
Published United States College of American Pathologists 01.10.2016
Subjects
Antigens, CD20 - metabolism
B-Lymphocytes - metabolism
B-Lymphocytes - pathology
Diagnosis
Diagnosis, Differential
Humans
Immunophenotyping
Non-Hodgkin's lymphomas
PAX5 Transcription Factor - metabolism
Plasma Cells - metabolism
Plasma Cells - pathology
Plasmablastic Lymphoma - diagnosis
Plasmablastic Lymphoma - metabolism
Plasmablastic Lymphoma - therapy
Prognosis
Survival Analysis
T cells
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Summary:Plasmablastic lymphoma (PBL) is a challenging diagnosis given its rarity and lack of expression of markers that are usually used by pathologists in establishing hematopoietic lineage. However, knowledge of the characteristic clinical setting, sites of involvement, and morphologic features of plasmablastic lymphoma can aid in the correct diagnosis of a suspected large cell lymphoma that is negative for B-cell- and T-cell-specific antigens. Herein, we review the clinical and pathologic features of plasmablastic lymphoma with an emphasis on the differential diagnosis of hematolymphoid neoplasms with immunoblastic morphology and/or evidence of plasmacytic differentiation by immunophenotype.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0003-9985
1543-2165
1543-2165
DOI:10.5858/arpa.2016-0232-ra