Effects of Intranasal Oxytocin on the Neural Basis of Face Processing in Autism Spectrum Disorder

• Published in: Biological psychiatry (1969) Vol. 74; no. 3; pp. 164 - 171
• Main Authors: Domes, Gregor, Heinrichs, Markus, Kumbier, Ekkehardt, Grossmann, Annette, Hauenstein, Karlheinz, Herpertz, Sabine C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.08.2013; Elsevier
• Subjects: Administration, Intranasal; Adolescent; Adult; Amygdala; Amygdala - blood supply; Amygdala - drug effects; Amygdala - physiopathology; autism; Biological and medical sciences; Brain Mapping; Child; Child clinical studies; Child Development Disorders, Pervasive - drug therapy; Child Development Disorders, Pervasive - pathology; Cross-Over Studies; Developmental disorders; Discrimination (Psychology) - drug effects; Double-Blind Method; face processing; Female; fMRI; Humans; Image Processing, Computer-Assisted; Infantile autism; Magnetic Resonance Imaging; Male; Medical sciences; Oxygen - blood; oxytocin; Oxytocin - administration & dosage; Pattern Recognition, Visual - radiation effects; Photic Stimulation; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; social cognition; Time Factors; Young Adult; fMRI; oxytocin; Amygdala; social cognition; autism; face processing; Oxytocin; Central nervous system; Basal ganglion; Developmental disorder; Nuclear magnetic resonance imaging; Autism spectrum disorder; Social cognition; Encephalon; Autism; Pervasive developmental disorder; Information processing; Functional magnetic resonance imaging; Medical imagery; Face; Amygdaloid nucleus; Functional imaging

Autism spectrum disorder (ASD) is associated with altered face processing and decreased activity in brain regions involved in face processing. The neuropeptide oxytocin has been shown to promote face processing and modulate brain activity in healthy adults. The present study examined the effects of...