Association of delayed chemoradiotherapy with elevated Epstein-Barr virus DNA load and adverse clinical outcome in nasopharyngeal carcinoma treatment during the COVID-19 pandemic: a retrospective study

• Published in: Cancer cell international Vol. 22; no. 1; pp. 1 - 8
• Main Authors: Huang, Cheng-Long, Fang, Xue-Liang, Mao, Yan-Ping, Guo, Rui, Li, Wen-Fei, Xu, Si-Si, Ma, Jun, Chen, Lei, Tang, Ling-Long
• Format: Journal Article
• Language: English
• Published: London BioMed Central 31.10.2022; BMC
• Subjects: Cancer therapies; Chemoradiotherapy; Chemotherapy; Clinical outcomes; Coronaviruses; COVID-19; COVID-19 pandemic; Deoxyribonucleic acid; Disease transmission; DNA; DNA viruses; EBV DNA; Epstein-Barr virus; Medical prognosis; Metastasis; Nasopharyngeal carcinoma; Pandemics; Patients; Radiation therapy; Severe acute respiratory syndrome coronavirus 2; Throat cancer; Tomography; Treatment delay; China

Background: To summarize the impact of radiotherapy (RT) and chemotherapy delays on patients with nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic. Methods: We retrospectively included 233 patients with stage II-IVa NPC treated with RT and chemotherapy between December 11, 2019 and March...