Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival

• Published in: Blood advances Vol. 4; no. 2; pp. 274 - 286
• Main Authors: Brück, Oscar, Dufva, Olli, Hohtari, Helena, Blom, Sami, Turkki, Riku, Ilander, Mette, Kovanen, Panu, Pallaud, Celine, Ramos, Pedro Marques, Lähteenmäki, Hanna, Välimäki, Katja, El Missiry, Mohamed, Ribeiro, Antonio, Kallioniemi, Olli, Porkka, Kimmo, Pellinen, Teijo, Mustjoki, Satu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.01.2020; American Society of Hematology
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Bone Marrow - metabolism; Female; Humans; Leukemia, Myeloid, Acute - immunology; Male; Middle Aged; Myeloid Neoplasia; Receptors, Antigen, T-Cell - genetics; Survival Analysis; Young Adult

The immunologic microenvironment in various solid tumors is aberrant and correlates with clinical survival. Here, we present a comprehensive analysis of the immune environment of acute myeloid leukemia (AML) bone marrow (BM) at diagnosis. We compared the immunologic landscape of formalin-fixed paraf...