The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

• Published in: Nature communications Vol. 11; no. 1; pp. 6348 - 11
• Main Authors: Agarwal, Shiuli, Vierbuchen, Tim, Ghosh, Sreya, Chan, Jennie, Jiang, Zhaozhao, Kandasamy, Richard K., Ricci, Emiliano, Fitzgerald, Katherine A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 14/32; 45/91; 49/15; 49/88; 49/90; 631/250; 631/250/262; Animal models; Animals; Biological activity; Biological Phenomena; Chromatin; Chromatin - metabolism; Cytokines - metabolism; Feedback; Gene deletion; Gene Expression Regulation; Gene Knockdown Techniques; Genes; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunity, Innate - drug effects; Immunology; Immunoregulation; Inflammation; Inflammatory response; Innate immunity; Interferon; Interferons - metabolism; Life Sciences; Lipopolysaccharides; Lipopolysaccharides - adverse effects; Mice; multidisciplinary; Myeloid cells; Myeloid Cells - metabolism; Negative feedback; Non-coding RNA; Nuclei (cytology); Oxidoreductases Acting on CH-CH Group Donors; Proteins; Regulators; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Stat1 protein; STAT1 Transcription Factor - metabolism; THP-1 Cells; Transcription; Innate Immune Response; LncRNA; Interferon IFN

Long non-coding RNAs are important regulators of biological processes including immune responses. The immunoregulatory functions of lncRNAs have been revealed primarily in murine models with limited understanding of lncRNAs in human immune responses. Here, we identify lncRNA LUCAT1 which is upregula...