A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration

• Published in: Cellular and molecular life sciences : CMLS Vol. 81; no. 1; p. 158
• Main Authors: Liang, Shuzhang, Zhou, Yating, Chang, Yue, Li, Jiayi, Zhang, Min, Gao, Peng, Li, Qi, Yu, Hong, Kawakami, Koichi, Ma, Jinmin, Zhang, Ruilin
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2024; Springer Nature B.V
• Subjects: Animal models; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cardiomyocytes; Cardiomyopathy; Cardiomyopathy, Hypertrophic - genetics; Cardiomyopathy, Hypertrophic - metabolism; Cell Biology; Coronary artery disease; Cysteine; Cysteine - genetics; Cysteine - metabolism; Danio rerio; Dilated cardiomyopathy; genomics; Glycine; glycine (amino acid); Heart; Heart diseases; heterozygosity; homozygosity; Humans; larvae; Life Sciences; LIM Domain Proteins; LIM protein; loci; Muscle Proteins - genetics; Muscle Proteins - metabolism; Muscles; mutants; Myocytes, Cardiac - metabolism; Original; Original Article; Pathogenesis; Proteins; Regeneration; sarcomeres; Signal transduction; Skeletal muscle; striated muscle; Ventricle; Zebrafish; Zebrafish - genetics; Zebrafish - metabolism; Heart regeneration; Trabeculation; Gene-trap; Heart development; csrp3/mlp
• ISSN: 1420-682X; 1420-9071; 1420-9071
• DOI: 10.1007/s00018-024-05189-0

Mutations in cysteine and glycine-rich protein 3 (CSRP3)/muscle LIM protein (MLP), a key regulator of striated muscle function, have been linked to hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in patients. However, the roles of CSRP3 in heart development and regeneration are no...