Effect of chemoprevention by low-dose aspirin of new or recurrent colorectal adenomas in patients with Lynch syndrome (AAS-Lynch): study protocol for a multicenter, double-blind, placebo-controlled randomized controlled trial

• Published in: Current controlled trials in cardiovascular medicine Vol. 21; no. 1; p. 764
• Main Authors: Soualy, Adil, Deutsch, David, Benallaoua, Mourad, Ait-Omar, Amal, Mary, Florence, Helfen, Sabine, Boubaya, Marouane, Levy, Vincent, Benamouzig, Robert, Aït Omar, Amal, Al-Khafaji, Semaher, Demare, Noémie, Perkins, Géraldine, Laurent-Puig, Pierre, Saurin, Jean-Christophe, Raby, Naouele, Venat-Bouvet, Laurence, Penaud, Corinne, Bonnet, Delphine, Sicart, Virginie, Pomes, Chloé, Lecomte, Thierry, Jollivet, Claire, Caulet, Morgane, Chaussade, Stanislas, Dhooge, Marion, Maksimovic, Fanny, Grandval, Philippe, Olschwang, Sylvie, Saussereau, Maud, Bellanger, Jérôme, Netter-Coti, Anne, Delhomelle, Hélène, Buecher, Bruno, Mehdi, Lydia, Lejeune, Sophie, Brahimi, Afane, Cattan, Stéphane, Bellengier, Laurence, Tougeron, David, Rafert, Sandrine, Barouk Simonet, Emmanuelle, Cornelis, François, Serova-Erard, Anna, Malka, David, Gesta, Paul, Oddoz, Jeanne, Mari, Véronique, Lesourd, Samuel, Kergoat, Gaëlle, Crivelli, Louise, Sobhani, Iradj, Amiot, Aurélien, Lepage, Côme, Faivre-Olivier, Laurence, Jouve, Jean-Louis, Drouillard, Antoine, Perot, Nora, Bardou, Marc, Nambot, Sophie, Mekahli, Nadia, Lortholary, Alain, Lenne, Carole, Lagasse, Jean-Paul, Ouahrani, Brahim, Frebourg, Thierry, Parodi, Nathalie, Branchaud, Maud, Desseigne, Françoise, Grinand, Elodie, Ingster, Olivier, Semelin, Benoit, Fein, Francine, Lourenco, Nelson, Aparicio, Thomas, Brasseur, Mathilde, Lopez, Anthony
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 04.09.2020; BioMed Central; BMC
• Subjects: Adenoma; Age; Aspirin; Clinical trials; Colonoscopy; Colorectal cancer; Consent; Dosage and administration; Double-blind studies; Drug therapy; Endoscopy; Family medical history; Genes; Genetic disorders; Hemorrhage; Life Sciences; Nonsteroidal anti-inflammatory drugs; Patients; Polyps; Prevention; Study Protocol; Surveillance; Tumors; France

Abstract Lynch syndrome (LS) is the most common cause of inherited colorectal cancer (CRC) and confers a high lifetime risk of CRC estimated to be up to 60%. Colonoscopy is recommended every 2 years in LS patients above the 20–25-year-old age bracket, and every year when colonic neoplasia has been d...