Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

• Published in: Journal of nanobiotechnology Vol. 19; no. 1; pp. 1 - 20
• Main Authors: Li, Shenglong, Liu, Jie, Liu, Siyu, Jiao, Weijie, Wang, Xiaohong
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 30.06.2021; BioMed Central; BMC
• Subjects: Aggrecan; Apoptosis; Arthritis; Biological activity; Biological products; Biomedical materials; Bone marrow; Care and treatment; Cartilage; Cartilage diseases; Cbfa-1 protein; Cell culture; Cell growth; Cell organelles; Cellular signal transduction; Chondrocytes; Circular RNA HIPK3 (circHIPK3); Collagen (type II); Collagenase 3; Development and progression; Extracellular vesicles; Gene expression; Genetic aspects; Genomes; Growth factors; Health aspects; Hypertrophy; IL-1β; Kinases; Matrix metalloproteinases; Medical research; Mesenchymal stem cells; Mesenchymal stem cells (MSCs); Metalloproteinase; MiR-124-3p; MYH9; Osteoarthritis; Pathogenesis; Physiological aspects; Proteins; Regeneration; Sox9 protein; Stem cell transplantation; Stem cells; Therapeutics, Experimental; Vesicles; China

Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biol...