Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biol...

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Published inJournal of nanobiotechnology Vol. 19; no. 1; pp. 1 - 20
Main Authors Li, Shenglong, Liu, Jie, Liu, Siyu, Jiao, Weijie, Wang, Xiaohong
Format Journal Article
LanguageEnglish
Published London BioMed Central Ltd 30.06.2021
BioMed Central
BMC
Subjects
Aggrecan
Apoptosis
Arthritis
Biological activity
Biological products
Biomedical materials
Bone marrow
Care and treatment
Cartilage
Cartilage diseases
Cbfa-1 protein
Cell culture
Cell growth
Cell organelles
Cellular signal transduction
Chondrocytes
Circular RNA HIPK3 (circHIPK3)
Collagen (type II)
Collagenase 3
Development and progression
Extracellular vesicles
Gene expression
Genetic aspects
Genomes
Growth factors
Health aspects
Hypertrophy
IL-1β
Kinases
Matrix metalloproteinases
Medical research
Mesenchymal stem cells
Mesenchymal stem cells (MSCs)
Metalloproteinase
MiR-124-3p
MYH9
Osteoarthritis
Pathogenesis
Physiological aspects
Proteins
Regeneration
Sox9 protein
Stem cell transplantation
Stem cells
Therapeutics, Experimental
Vesicles
China
Online AccessGet full text
ISSN1477-3155
1477-3155
DOI10.1186/s12951-021-00940-2

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Abstract Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA. Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1[beta] (IL-1[beta]) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1[beta]-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9. The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA.
AbstractList Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA. Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1[beta] (IL-1[beta]) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1[beta]-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9. The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA.
Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA.BACKGROUNDExtracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA.Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1β (IL-1β) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1β-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9.RESULTSCo-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1β (IL-1β) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1β-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9.The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA.CONCLUSIONThe findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA.
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA. Results Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1β (IL-1β) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1β-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9. Conclusion The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA. Graphic abstract
Abstract Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA. Results Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1β (IL-1β) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1β-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9. Conclusion The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA. Graphic abstract
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potential in the development of osteoarthritis (OA) previously. In this study, we explored the biological roles and underlying mechanism of MSCs-EVs in OA. Results Co-culture experiments revealed that MSCs-EVs could promote the expression of collagen type II alpha 1 chain (COL2A1), SRY-box transcription factor 9 (SOX9) and Aggrecan while negatively regulate the expression of chondrocyte hypertrophy markers matrix metallopeptidase 13 (MMP-13) and RUNX family transcription factor 2 (Runx2) in mouse chondrocytes in the OA model. Besides, the results of cell experiments indicated that MSCs-EVs could notably weaken the suppression of chondrocyte proliferation, migration and the promotion of chondrocyte apoptosis via interleukin1[beta] (IL-1[beta]) induction. In addition, MSCs-circHIPK3-EVs (EVs derived from MSCs overexpressing circHIPK3) considerably improved IL-1[beta]-induced chondrocyte injury. Mechanistically, we elucidated that circHIPK3 could directly bind to miR-124-3p and subsequently elevate the expression of the target gene MYH9. Conclusion The findings in our study demonstrated that EVs-circHIPK3 participated in MSCs-EVs-mediated chondrocyte proliferation and migration induction and in chondrocyte apoptosis inhibition via the miR-124-3p/MYH9 axis. This offers a promising novel cell-free therapy for treating OA. Graphic abstract Keywords: Mesenchymal stem cells (MSCs), Extracellular vesicles, Osteoarthritis, Circular RNA HIPK3 (circHIPK3), MiR-124-3p, MYH9
ArticleNumber 194
Audience Academic
Author Liu, Jie
Wang, Xiaohong
Liu, Siyu
Jiao, Weijie
Li, Shenglong
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  givenname: Xiaohong
  surname: Wang
  fullname: Wang, Xiaohong
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Cites_doi 10.1080/21691401.2019.1673765
10.7150/thno.46001
10.1002/wrna.1633
10.14336/AD.2019.1127
10.18632/aging.103003
10.1002/ctm2.255
10.1186/s13287-021-02138-7
10.2217/rme-2018-0161
10.1007/s12032-020-01413-6
10.1186/s13287-020-02001-1
10.7150/thno.56174
10.1002/adhm.202001689
10.1111/jcmm.15714
10.1016/j.gde.2020.12.018
10.3390/cancers13010084
10.1016/j.joca.2015.07.004
10.1080/15548627.2019.1634945
10.3389/fcell.2020.560117
10.1016/j.ecoenv.2020.110319
10.1016/j.lfs.2021.119143
10.1186/s13287-019-1545-x
10.1186/s13287-020-02011-z
10.1016/j.addr.2021.03.005
10.1016/j.lfs.2020.118987
10.1038/ncomms11215
10.1681/ASN.2015060707
10.1016/j.semcdb.2020.08.003
10.1161/CIRCULATIONAHA.120.049715
10.1007/s00441-020-03193-x
10.18632/aging.102674
10.1016/j.pharmthera.2015.02.003
10.1038/s41536-018-0041-8
10.1016/j.micromeso.2020.110200
10.1016/j.omtn.2020.11.008
10.1089/scd.2011.0670
10.14336/AD.2020.0309
10.2174/1872213X14666200130100236
10.1016/j.jconrel.2020.11.007
10.1186/s13287-021-02161-8
10.1634/stemcells.2004-0062
10.1186/s13018-017-0534-y
10.1517/14712598.2016.1093108
10.3892/ijmm.2020.4804
10.1007/s00167-018-4883-9
10.1186/s12935-020-01743-5
10.1039/D0BM01164A
10.1016/j.micromeso.2020.110173
10.1080/21655979.2020.1863014
10.1007/s13770-020-00324-x
10.14336/AD.2019.1116
10.1155/2013/732742
10.3390/cancers12092464
10.1155/2019/7954657
10.1038/s41576-019-0158-7
10.7150/thno.53326
10.1172/jci.insight.138530
10.3389/fcell.2020.567813
10.3389/fimmu.2020.577015
10.1186/s12974-019-1571-8
10.1177/0363546519899923
10.1016/j.devcel.2021.03.020
10.3389/fcell.2020.568366
10.1016/j.intimp.2019.105946
10.1155/2018/3057624
10.1007/s00441-020-03319-1
10.1002/jev2.12033
10.1038/s41419-017-0204-3
10.15252/embr.201643581
10.3390/cells8020177
10.3389/fendo.2020.00535
10.3389/fbioe.2020.575057
10.1038/s41598-017-15376-8
10.1007/978-1-4939-2550-6_15
10.1007/s11926-018-0776-7
10.1097/01.NAJ.0000580260.18537.ca
10.3389/fcell.2020.608388
10.1016/j.semcancer.2021.03.032
10.1038/s41419-019-1430-7
10.1186/s13287-020-01957-4
10.1177/1759720X20981219
10.1016/j.joca.2016.06.022
10.1038/s41580-020-0243-y
10.1038/ni.3002
10.1158/0008-5472.CAN-20-1010
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References CDS Ranmuthu (940_CR58) 2018; 20
Z Jin (940_CR69) 2020; 78
LL Chen (940_CR71) 2020; 21
TJ Kean (940_CR28) 2013; 2013
BC Heng (940_CR24) 2004; 22
J Liang (940_CR55) 2020; 12
X Yang (940_CR74) 2021; 47
BH Sung (940_CR33) 2021
M Najar (940_CR8) 2020; 8
YY Xiong (940_CR62) 2021; 11
S Cechova (940_CR80) 2018; 29
A Goldberg (940_CR15) 2017; 12
JX Zhang (940_CR50) 2019; 10
DW Greening (940_CR85) 2015; 1295
S An (940_CR7) 2020; 11
J Gu (940_CR18) 2020; 11
R Wang (940_CR38) 2021; 384
S Zhang (940_CR39) 2016; 24
MB Gugjoo (940_CR19) 2020; 14
J Freitag (940_CR57) 2019; 14
M Kim (940_CR64) 2021
G Ye (940_CR83) 2020; 10
X Zhao (940_CR66) 2020; 8
B Chen (940_CR54) 2019; 8
Z Zeng (940_CR70) 2021; 143
PI Artemaki (940_CR47) 2020; 12
M Hasegawa (940_CR4) 2020; 11
M Wang (940_CR12) 2020; 9
S Xiao (940_CR5) 2020; 328
Y Hu (940_CR78) 2021; 81
HN Abdelhamid (940_CR31) 2020; 302
M Qiu (940_CR65) 2021; 269
VVT Nguyen (940_CR36) 2020; 10
Z Xiao (940_CR11) 2021; 12
V Dexheimer (940_CR23) 2012; 21
A Yokoi (940_CR34) 2021
Y Wang (940_CR48) 2019; 2019
J Kim (940_CR16) 2015; 151
H Zhang (940_CR82) 2021; 12
HN Abdelhamid (940_CR30) 2020; 300
M Ruiz (940_CR26) 2016; 16
C Chang (940_CR10) 2021; 10
Y Li (940_CR52) 2017; 18
LS Kristensen (940_CR72) 2019; 20
H Ni (940_CR77) 2019; 47
T Seimiya (940_CR44) 2020; 8
X Chen (940_CR49) 2020; 16
YM Pers (940_CR25) 2015; 23
M Schulz-Siegmund (940_CR35) 2021; 173
N Zeng (940_CR6) 2020; 11
P Kangari (940_CR14) 2020; 11
JR Garza (940_CR21) 2020; 48
BS Guerra (940_CR46) 2020; 114
Z Rong (940_CR41) 2021; 11
B Wang (940_CR76) 2021; 270
Z Jin (940_CR68) 2020; 381
M Wang (940_CR29) 2018; 2018
Y Wang (940_CR27) 2014; 15
ST Yu (940_CR81) 2020; 11
R Duan (940_CR3) 2020; 8
KL Otterpohl (940_CR79) 2020
B Qiu (940_CR67) 2020; 24
K Stefanius (940_CR60) 2021; 66
H Zhang (940_CR2) 2020; 8
L Liang (940_CR32) 2021; 12
S Cosenza (940_CR40) 2017; 7
YH Pan (940_CR43) 2020; 11
Q Zheng (940_CR53) 2016; 7
Q Xie (940_CR13) 2020; 11
Y Tang (940_CR9) 2021; 12
G Chen (940_CR51) 2018; 9
R Bastos (940_CR22) 2018; 26
H Aheget (940_CR61) 2021; 13
H Iijima (940_CR20) 2018; 3
CG de Campos (940_CR1) 2020; 12
D Tsitsipatis (940_CR45) 2021; 12
S Dabrowska (940_CR17) 2019; 16
L Yan (940_CR37) 2021; 11
B Zhu (940_CR73) 2021; 21
SK Singh (940_CR84) 2020; 37
T Shao (940_CR42) 2021; 23
J Sha (940_CR75) 2020; 10
YS Chiu (940_CR56) 2020; 12
E Draganski (940_CR59) 2019; 119
Q Guan (940_CR63) 2020; 193
References_xml – volume: 47
  start-page: 4046
  year: 2019
  ident: 940_CR77
  publication-title: Artif Cells Nanomed Biotechnol
  doi: 10.1080/21691401.2019.1673765
– volume: 10
  start-page: 7545
  year: 2020
  ident: 940_CR83
  publication-title: Theranostics
  doi: 10.7150/thno.46001
– volume: 12
  start-page: e1633
  year: 2021
  ident: 940_CR45
  publication-title: Wiley Interdiscip Rev RNA
  doi: 10.1002/wrna.1633
– volume: 11
  start-page: 1146
  year: 2020
  ident: 940_CR7
  publication-title: Aging Dis
  doi: 10.14336/AD.2019.1127
– volume: 12
  start-page: 6630
  year: 2020
  ident: 940_CR56
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.103003
– volume: 11
  start-page: e255
  year: 2021
  ident: 940_CR37
  publication-title: Clin Transl Med
  doi: 10.1002/ctm2.255
– volume: 12
  start-page: 71
  year: 2021
  ident: 940_CR9
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-021-02138-7
– volume: 14
  start-page: 213
  year: 2019
  ident: 940_CR57
  publication-title: Regen Med
  doi: 10.2217/rme-2018-0161
– volume: 37
  start-page: 88
  year: 2020
  ident: 940_CR84
  publication-title: Med Oncol
  doi: 10.1007/s12032-020-01413-6
– volume: 11
  start-page: 492
  year: 2020
  ident: 940_CR14
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-020-02001-1
– volume: 11
  start-page: 2755
  year: 2021
  ident: 940_CR41
  publication-title: Theranostics
  doi: 10.7150/thno.56174
– volume: 10
  start-page: 2001689
  year: 2021
  ident: 940_CR10
  publication-title: Adv Healthc Mater
  doi: 10.1002/adhm.202001689
– volume: 24
  start-page: 10855
  year: 2020
  ident: 940_CR67
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.15714
– volume: 66
  start-page: 83
  year: 2021
  ident: 940_CR60
  publication-title: Curr Opin Genet Dev
  doi: 10.1016/j.gde.2020.12.018
– volume: 13
  start-page: 84
  issue: 1
  year: 2021
  ident: 940_CR61
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers13010084
– volume: 23
  start-page: 2027
  year: 2015
  ident: 940_CR25
  publication-title: Osteoarthr Cartil
  doi: 10.1016/j.joca.2015.07.004
– volume: 16
  start-page: 659
  year: 2020
  ident: 940_CR49
  publication-title: Autophagy
  doi: 10.1080/15548627.2019.1634945
– volume: 8
  start-page: 560117
  year: 2020
  ident: 940_CR2
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.560117
– volume: 193
  start-page: 110319
  year: 2020
  ident: 940_CR63
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110319
– volume: 270
  start-page: 119143
  year: 2021
  ident: 940_CR76
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2021.119143
– volume: 11
  start-page: 43
  year: 2020
  ident: 940_CR18
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-019-1545-x
– volume: 11
  start-page: 519
  year: 2020
  ident: 940_CR13
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-020-02011-z
– volume: 173
  start-page: 89
  year: 2021
  ident: 940_CR35
  publication-title: Adv Drug Deliv Rev
  doi: 10.1016/j.addr.2021.03.005
– volume: 269
  start-page: 118987
  year: 2021
  ident: 940_CR65
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2020.118987
– volume: 7
  start-page: 11215
  year: 2016
  ident: 940_CR53
  publication-title: Nat Commun
  doi: 10.1038/ncomms11215
– volume: 29
  start-page: 155
  year: 2018
  ident: 940_CR80
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2015060707
– volume: 114
  start-page: 1
  year: 2020
  ident: 940_CR46
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2020.08.003
– volume: 143
  start-page: 354
  year: 2021
  ident: 940_CR70
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.120.049715
– volume: 381
  start-page: 99
  year: 2020
  ident: 940_CR68
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-020-03193-x
– volume: 12
  start-page: 1159
  year: 2020
  ident: 940_CR55
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.102674
– volume: 151
  start-page: 8
  year: 2015
  ident: 940_CR16
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2015.02.003
– volume: 3
  start-page: 15
  year: 2018
  ident: 940_CR20
  publication-title: NPJ Regen Med
  doi: 10.1038/s41536-018-0041-8
– volume: 302
  start-page: 110200
  year: 2020
  ident: 940_CR31
  publication-title: Micropor Mesopor Mat.
  doi: 10.1016/j.micromeso.2020.110200
– volume: 23
  start-page: 369
  year: 2021
  ident: 940_CR42
  publication-title: Mol Ther Nucleic Acids
  doi: 10.1016/j.omtn.2020.11.008
– volume: 21
  start-page: 2160
  year: 2012
  ident: 940_CR23
  publication-title: Stem Cells Dev
  doi: 10.1089/scd.2011.0670
– volume: 11
  start-page: 1585
  year: 2020
  ident: 940_CR43
  publication-title: Aging Dis
  doi: 10.14336/AD.2020.0309
– volume: 14
  start-page: 3
  year: 2020
  ident: 940_CR19
  publication-title: Recent Pat Inflamm Allergy Drug Discov
  doi: 10.2174/1872213X14666200130100236
– volume: 328
  start-page: 817
  year: 2020
  ident: 940_CR5
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.11.007
– volume: 12
  start-page: 87
  year: 2021
  ident: 940_CR32
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-021-02161-8
– volume: 22
  start-page: 1152
  year: 2004
  ident: 940_CR24
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2004-0062
– volume: 12
  start-page: 39
  year: 2017
  ident: 940_CR15
  publication-title: J Orthop Surg Res
  doi: 10.1186/s13018-017-0534-y
– volume: 16
  start-page: 33
  year: 2016
  ident: 940_CR26
  publication-title: Expert Opin Biol Ther
  doi: 10.1517/14712598.2016.1093108
– volume: 47
  start-page: 668
  year: 2021
  ident: 940_CR74
  publication-title: Int J Mol Med
  doi: 10.3892/ijmm.2020.4804
– volume: 26
  start-page: 3342
  year: 2018
  ident: 940_CR22
  publication-title: Knee Surg Sports Traumatol Arthrosc
  doi: 10.1007/s00167-018-4883-9
– volume: 21
  start-page: 70
  year: 2021
  ident: 940_CR73
  publication-title: Cancer Cell Int
  doi: 10.1186/s12935-020-01743-5
– volume: 10
  start-page: 4372
  year: 2020
  ident: 940_CR75
  publication-title: Am J Cancer Res
– volume: 9
  start-page: 1088
  issue: 4
  year: 2020
  ident: 940_CR12
  publication-title: Biomater Sci
  doi: 10.1039/D0BM01164A
– volume: 300
  start-page: 110173
  year: 2020
  ident: 940_CR30
  publication-title: Micropor Mesopor Mat
  doi: 10.1016/j.micromeso.2020.110173
– volume: 12
  start-page: 162
  year: 2021
  ident: 940_CR82
  publication-title: Bioengineered
  doi: 10.1080/21655979.2020.1863014
– year: 2021
  ident: 940_CR64
  publication-title: Tissue Eng Regen Med
  doi: 10.1007/s13770-020-00324-x
– volume: 11
  start-page: 1317
  year: 2020
  ident: 940_CR6
  publication-title: Aging Dis
  doi: 10.14336/AD.2019.1116
– volume: 2013
  start-page: 732742
  year: 2013
  ident: 940_CR28
  publication-title: Stem Cells Int.
  doi: 10.1155/2013/732742
– volume: 12
  start-page: 2464
  issue: 9
  year: 2020
  ident: 940_CR47
  publication-title: Cancers (Basel).
  doi: 10.3390/cancers12092464
– volume: 2019
  start-page: 7954657
  year: 2019
  ident: 940_CR48
  publication-title: Oxid Med Cell Longev
  doi: 10.1155/2019/7954657
– volume: 20
  start-page: 675
  year: 2019
  ident: 940_CR72
  publication-title: Nat Rev Genet
  doi: 10.1038/s41576-019-0158-7
– volume: 11
  start-page: 1046
  year: 2021
  ident: 940_CR62
  publication-title: Theranostics
  doi: 10.7150/thno.53326
– year: 2020
  ident: 940_CR79
  publication-title: JCI Insight.
  doi: 10.1172/jci.insight.138530
– volume: 8
  start-page: 567813
  year: 2020
  ident: 940_CR8
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.567813
– volume: 11
  start-page: 577015
  year: 2020
  ident: 940_CR4
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2020.577015
– volume: 16
  start-page: 178
  year: 2019
  ident: 940_CR17
  publication-title: J Neuroinflammation
  doi: 10.1186/s12974-019-1571-8
– volume: 48
  start-page: 588
  year: 2020
  ident: 940_CR21
  publication-title: Am J Sports Med
  doi: 10.1177/0363546519899923
– year: 2021
  ident: 940_CR33
  publication-title: Dev Cell
  doi: 10.1016/j.devcel.2021.03.020
– volume: 8
  start-page: 568366
  year: 2020
  ident: 940_CR44
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.568366
– volume: 78
  start-page: 105946
  year: 2020
  ident: 940_CR69
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2019.105946
– volume: 2018
  start-page: 3057624
  year: 2018
  ident: 940_CR29
  publication-title: Stem Cells Int
  doi: 10.1155/2018/3057624
– volume: 384
  start-page: 113
  issue: 1
  year: 2021
  ident: 940_CR38
  publication-title: Cell Tissue Res
  doi: 10.1007/s00441-020-03319-1
– volume: 10
  start-page: e12033
  year: 2020
  ident: 940_CR36
  publication-title: J Extracell Vesicles
  doi: 10.1002/jev2.12033
– volume: 9
  start-page: 175
  year: 2018
  ident: 940_CR51
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-017-0204-3
– volume: 18
  start-page: 1646
  year: 2017
  ident: 940_CR52
  publication-title: EMBO Rep
  doi: 10.15252/embr.201643581
– volume: 8
  start-page: 177
  issue: 2
  year: 2019
  ident: 940_CR54
  publication-title: Cells
  doi: 10.3390/cells8020177
– volume: 11
  start-page: 535
  year: 2020
  ident: 940_CR81
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2020.00535
– volume: 8
  start-page: 575057
  year: 2020
  ident: 940_CR66
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2020.575057
– volume: 7
  start-page: 16214
  year: 2017
  ident: 940_CR40
  publication-title: Sci Rep
  doi: 10.1038/s41598-017-15376-8
– volume: 1295
  start-page: 179
  year: 2015
  ident: 940_CR85
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-4939-2550-6_15
– volume: 20
  start-page: 67
  year: 2018
  ident: 940_CR58
  publication-title: Curr Rheumatol Rep
  doi: 10.1007/s11926-018-0776-7
– volume: 119
  start-page: 47
  year: 2019
  ident: 940_CR59
  publication-title: Am J Nurs
  doi: 10.1097/01.NAJ.0000580260.18537.ca
– volume: 8
  start-page: 608388
  year: 2020
  ident: 940_CR3
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2020.608388
– year: 2021
  ident: 940_CR34
  publication-title: Semin Cancer Biol
  doi: 10.1016/j.semcancer.2021.03.032
– volume: 10
  start-page: 182
  year: 2019
  ident: 940_CR50
  publication-title: Cell Death Dis
  doi: 10.1038/s41419-019-1430-7
– volume: 12
  start-page: 5
  year: 2021
  ident: 940_CR11
  publication-title: Stem Cell Res Ther
  doi: 10.1186/s13287-020-01957-4
– volume: 12
  start-page: 1759720X2098121
  year: 2020
  ident: 940_CR1
  publication-title: Ther Adv Musculoskelet Dis.
  doi: 10.1177/1759720X20981219
– volume: 24
  start-page: 2135
  year: 2016
  ident: 940_CR39
  publication-title: Osteoarthr Cartil
  doi: 10.1016/j.joca.2016.06.022
– volume: 21
  start-page: 475
  year: 2020
  ident: 940_CR71
  publication-title: Nat Rev Mol Cell Biol
  doi: 10.1038/s41580-020-0243-y
– volume: 15
  start-page: 1009
  year: 2014
  ident: 940_CR27
  publication-title: Nat Immunol
  doi: 10.1038/ni.3002
– volume: 81
  start-page: 713
  year: 2021
  ident: 940_CR78
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-20-1010
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Snippet Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage...
Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including...
Abstract Background Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes,...
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Aggregation Database
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StartPage 1
SubjectTerms Aggrecan
Apoptosis
Arthritis
Biological activity
Biological products
Biomedical materials
Bone marrow
Care and treatment
Cartilage
Cartilage diseases
Cbfa-1 protein
Cell culture
Cell growth
Cell organelles
Cellular signal transduction
Chondrocytes
Circular RNA HIPK3 (circHIPK3)
Collagen (type II)
Collagenase 3
Development and progression
Extracellular vesicles
Gene expression
Genetic aspects
Genomes
Growth factors
Health aspects
Hypertrophy
IL-1β
Kinases
Matrix metalloproteinases
Medical research
Mesenchymal stem cells
Mesenchymal stem cells (MSCs)
Metalloproteinase
MiR-124-3p
MYH9
Osteoarthritis
Pathogenesis
Physiological aspects
Proteins
Regeneration
Sox9 protein
Stem cell transplantation
Stem cells
Therapeutics, Experimental
Vesicles
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Title Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis
URI https://www.proquest.com/docview/2553319687
https://www.proquest.com/docview/2547534492
https://pubmed.ncbi.nlm.nih.gov/PMC8244143
https://doaj.org/article/1d17d37f0aa344edab2e6d15fba44555
Volume 19
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