Green Tea Catechin Epigallocatechin Gallate Inhibits Vegetative Cell Outgrowth and Expression of Beta-Lactamase Genes in Penicillin-Resistant Bacillus anthracis Strain PCr

• Published in: Pathogens Vol. 13; no. 8; p. 699
• Main Authors: Okutani, Akiko, Morikawa, Shigeru, Maeda, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.08.2024; MDPI
• Subjects: Anthrax; Anti-Bacterial Agents - pharmacology; Antibiotics; Antimicrobial activity; Bacillus anthracis; Bacillus anthracis - drug effects; Bacillus anthracis - genetics; Bacteria; beta-lactamase; beta-Lactamases - genetics; beta-Lactamases - metabolism; Catechin; Catechin - analogs & derivatives; Catechin - pharmacology; Epigallocatechin gallate; Gene Expression Regulation, Bacterial - drug effects; Genes; Genomes; Gram-positive bacteria; Green tea; green tea catechin; Medicine; Meropenem; Meropenem - pharmacology; Microbial Sensitivity Tests; Minimum inhibitory concentration; Penicillin; Penicillin Resistance - genetics; penicillins; Penicillins - pharmacology; R; Spores; Spores, Bacterial - drug effects; Spores, Bacterial - genetics; Staphylococcus infections; Tea - chemistry; Variance analysis; Vegetative cells; β Lactamase; United States > US; Japan; penicillin; Bacillus anthracis; beta-lactamase; green tea catechin

The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells der...