Green Tea Catechin Epigallocatechin Gallate Inhibits Vegetative Cell Outgrowth and Expression of Beta-Lactamase Genes in Penicillin-Resistant Bacillus anthracis Strain PCr
The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells der...
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| Published in | Pathogens Vol. 13; no. 8; p. 699 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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19.08.2024
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| Abstract | The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant B. anthracis. In the penicillin-resistant B. anthracis strain, the transcription levels of the beta-lactamase genes (bla1 and bla2) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant B. anthracis growth and beta-lactamase production. |
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| AbstractList | The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant B. anthracis. In the penicillin-resistant B. anthracis strain, the transcription levels of the beta-lactamase genes (bla1 and bla2) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant B. anthracis growth and beta-lactamase production.The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant B. anthracis. In the penicillin-resistant B. anthracis strain, the transcription levels of the beta-lactamase genes (bla1 and bla2) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant B. anthracis growth and beta-lactamase production. The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant B. anthracis. In the penicillin-resistant B. anthracis strain, the transcription levels of the beta-lactamase genes (bla1 and bla2) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant B. anthracis growth and beta-lactamase production. The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on spores and vegetative cells. The spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant . In the penicillin-resistant strain, the transcription levels of the beta-lactamase genes ( and ) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant growth and beta-lactamase production. The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on Bacillus anthracis spores and vegetative cells. The B. anthracis spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant B. anthracis . In the penicillin-resistant B. anthracis strain, the transcription levels of the beta-lactamase genes ( bla1 and bla2 ) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant B. anthracis growth and beta-lactamase production. |
| Author | Ken Maeda Shigeru Morikawa Akiko Okutani |
| AuthorAffiliation | Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan; morikawa@niid.go.jp (S.M.); kmaeda@niid.go.jp (K.M.) |
| AuthorAffiliation_xml | – name: Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan; morikawa@niid.go.jp (S.M.); kmaeda@niid.go.jp (K.M.) |
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| Cites_doi | 10.1038/sj.embor.7400118 10.1002/mnfr.200600173 10.1128/MRA.00670-19 10.1128/AAC.49.10.4339-4343.2005 10.1128/AAC.48.6.1968-1973.2004 10.1371/journal.pone.0089112 10.1093/femsle/fnx127 10.1128/AAC.00706-06 10.1111/bph.12009 10.1128/JB.185.3.823-830.2003 10.1128/AAC.01016-10 10.4315/0362-028X-69.2.354 10.1099/mic.0.081448-0 10.1089/bsp.2011.0095 10.1080/09168451.2014.993356 10.1016/j.meegid.2019.03.022 10.1128/microbiolspec.TBS-0014-2012 10.3390/molecules23051125 10.1155/2018/9105261 10.1016/j.mam.2009.07.004 10.1128/AAC.46.7.2266-2268.2002 10.1371/journal.pone.0048880 10.1089/bsp.2010.0053 10.1056/NEJMoa012948 10.1128/AAC.45.6.1737-1742.2001 10.1111/j.1365-2958.2011.07915.x |
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| Keywords | penicillin Bacillus anthracis beta-lactamase green tea catechin |
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| SubjectTerms | Anthrax Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial activity Bacillus anthracis Bacillus anthracis - drug effects Bacillus anthracis - genetics Bacteria beta-lactamase beta-Lactamases - genetics beta-Lactamases - metabolism Catechin Catechin - analogs & derivatives Catechin - pharmacology Epigallocatechin gallate Gene Expression Regulation, Bacterial - drug effects Genes Genomes Gram-positive bacteria Green tea green tea catechin Medicine Meropenem Meropenem - pharmacology Microbial Sensitivity Tests Minimum inhibitory concentration Penicillin Penicillin Resistance - genetics penicillins Penicillins - pharmacology R Spores Spores, Bacterial - drug effects Spores, Bacterial - genetics Staphylococcus infections Tea - chemistry Variance analysis Vegetative cells β Lactamase |
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| Title | Green Tea Catechin Epigallocatechin Gallate Inhibits Vegetative Cell Outgrowth and Expression of Beta-Lactamase Genes in Penicillin-Resistant Bacillus anthracis Strain PCr |
| URI | https://cir.nii.ac.jp/crid/1870303266600110976 https://www.ncbi.nlm.nih.gov/pubmed/39204299 https://www.proquest.com/docview/3097998761 https://www.proquest.com/docview/3099794886 https://www.proquest.com/docview/3153757645 https://pubmed.ncbi.nlm.nih.gov/PMC11356866 https://doaj.org/article/ba9cbbe5529d4b2fb3543ced44beabbf |
| Volume | 13 |
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