Disrupted Functional Brain Connectome in Individuals at Risk for Alzheimer's Disease

• Published in: Biological psychiatry (1969) Vol. 73; no. 5; pp. 472 - 481
• Main Authors: Wang, Jinhui, Zuo, Xinian, Dai, Zhengjia, Xia, Mingrui, Zhao, Zhilian, Zhao, Xiaoling, Jia, Jianping, Han, Ying, He, Yong
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.03.2013; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Aged; Alzheimer Disease - physiopathology; Amnesia - physiopathology; Biological and medical sciences; Brain - physiopathology; Brain Mapping; Cognitive Dysfunction - physiopathology; Connectivity; Connectome; connectomics; default-mode; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; MCI; Medical sciences; Middle Aged; modularity; Nerve Net - physiopathology; Neurology; Organic mental disorders. Neuropsychology; Psychiatric/Mental Health; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Reproducibility of Results; Risk; small-world; World; Connectivity; connectomics; MCI; modularity; default-mode; small-world; Nervous system diseases; Alzheimer disease; Central nervous system; Cerebral disorder; Encephalon; Central nervous system disease; Risk factor; Degenerative disease

Alzheimer's disease disrupts the topological architecture of whole-brain connectivity (i.e., the connectome); however, whether this disruption is present in amnestic mild cognitive impairment (aMCI), the prodromal stage of Alzheimer's disease, remains largely unknown. We employed resting-s...