Animal models for HIV/AIDS research

• Published in: Nature reviews. Microbiology Vol. 10; no. 12; pp. 852 - 867
• Main Authors: Hatziioannou, Theodora, Evans, David T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2012; Nature Publishing Group
• Subjects: 631/1647/767/1424; 692/699/255/1901; Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - immunology; Acquired Immunodeficiency Syndrome - prevention & control; AIDS; AIDS Vaccines - immunology; AIDS Vaccines - pharmacology; Animal models; Animal models in research; Animals; Anti-HIV Agents - pharmacology; Antiretroviral agents; Antiretroviral drugs; Antiviral agents; Apolipoprotein B; Biomedical and Life Sciences; Care and treatment; CD4 antigen; Disease Models, Animal; Drug resistance; Drugs; Effectiveness; Genetic aspects; Health aspects; HIV; HIV - immunology; HIV infection; HIV Infections - immunology; HIV Infections - prevention & control; Host range; Human immunodeficiency virus; Human immunodeficiency virus 1; Human tissues; Humans; Immune system; Immunosuppressive agents; In vivo methods and tests; Infections; Infectious Diseases; Life Sciences; Lymphocytes; Lymphocytes T; Medical Microbiology; Microbiology; Monkeys & apes; Pandemics; Parasitology; Prevention; Primates; Proteins; Public health; Recombinants; review-article; Vaccines; Viral infections; Virology; Viruses; United States; United States > US

Key Points Animal models are essential for testing antiretroviral drugs to treat HIV infection of humans and for acquiring the basic scientific knowledge that will ultimately be needed to develop a safe and effective vaccine against HIV-1. Owing to the narrow host range of HIV, HIV-1 infection of mi...