Anticancer potentiality and mode of action of low-carbohydrate proteins and peptides from mushrooms

• Published in: Applied microbiology and biotechnology Vol. 104; no. 16; pp. 6855 - 6871
• Main Authors: Rezvani, Vala, Pourianfar, Hamid R., Mohammadnejad, Safoora, Madjid Ansari, Alireza, Farahmand, Leila
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2020; Springer; Springer Nature B.V
• Subjects: Agaricales - chemistry; Amino acids; Anticancer properties; antineoplastic activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Antitumor activity; Apoptosis; Apoptosis - drug effects; Bioactive compounds; Biological Products - chemistry; Biological Products - pharmacology; Biomedical and Life Sciences; Biotechnology; Cancer; Cancer research; Cancer therapies; cancer therapy; Carbohydrates; Carbohydrates - analysis; Cell membranes; chemical structure; Chemotherapy; Complex compounds; death domain receptors; Drug resistance; drug therapy; Fungal Proteins - chemistry; Fungal Proteins - pharmacology; Glycoproteins; Health aspects; Humans; Immunologic Factors - chemistry; Immunologic Factors - pharmacology; Immunomodulation; Immunomodulators; Lectins; Life Sciences; mechanism of action; Medical research; Microbial Genetics and Genomics; Microbiology; Mini-Review; Mitochondria; Mode of action; Mushrooms; Peptides; Peptides - chemistry; Peptides - pharmacology; Polysaccharides; Protein binding; Proteins; Side effects; Ubiquitin; Iran; Canada; Anticancer; Chemical structure; Mushroom; Mode of action; Low-carbohydrate protein

Severe side effects of chemotherapy as well as drug resistance highlight the ongoing need to discover novel natural bioactive compounds with anticancer potentiality. Mushroom-derived proteins are among the naturally occurring compounds that have been the subject of a body of research on their potent...