Biotin Interference in Clinical Immunoassays: A Cause for Concern

• Published in: Archives of pathology & laboratory medicine (1976) Vol. 141; no. 11; pp. 1459 - 1460
• Main Authors: Holmes, Earle W., Samarasinghe, Shanika, Emanuele, Mary Ann, Meah, Farah
• Format: Journal Article
• Language: English
• Published: United States College of American Pathologists 01.11.2017
• Subjects: Accuracy; Biotin; Biotin - adverse effects; Biotin - blood; Causes of; Data Accuracy; Diagnostic errors; Dietary supplements; Dietary Supplements - adverse effects; Dietary Supplements - analysis; Drug dosages; Endocrinology; Humans; Immunoassay; Immunoassay - methods; Infectious diseases; Methods; Physiological aspects; Risk Management; United States; United States > US

To the Editor.-An increase in the use of biotin supplements by the general public is producing an increase in the number of reports of analytic interference in biotin-based immunoassays (BBAs) used to evaluate endocrine function.1,2 The fact that BBAs of similar design are currently used to diagnose...