Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer

The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 20...

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Published inNature communications Vol. 14; no. 1; pp. 5105 - 15
Main Authors McBride, Dillon S., Garushyants, Sofya K., Franks, John, Magee, Andrew F., Overend, Steven H., Huey, Devra, Williams, Amanda M., Faith, Seth A., Kandeil, Ahmed, Trifkovic, Sanja, Miller, Lance, Jeevan, Trushar, Patel, Anami, Nolting, Jacqueline M., Tonkovich, Michael J., Genders, J. Tyler, Montoney, Andrew J., Kasnyik, Kevin, Linder, Timothy J., Bevins, Sarah N., Lenoch, Julianna B., Chandler, Jeffrey C., DeLiberto, Thomas J., Koonin, Eugene V., Suchard, Marc A., Lemey, Philippe, Webby, Richard J., Nelson, Martha I., Bowman, Andrew S.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 28.08.2023
Nature Publishing Group
Nature Portfolio
Subjects
13/1
13/106
45/23
45/88
45/90
631/181/735
631/181/757
631/326/596/4130
692/699/255/2514
692/700/478/174
Animal models
Animals
Bayes Theorem
Bayesian analysis
COVID-19
COVID-19 - veterinary
COVID-19 infection
Deer
Disease transmission
ecology
Epidemiology
Evolution
Humanities and Social Sciences
Humans
Livestock
long term effects
Mathematical models
multidisciplinary
Odocoileus virginianus
Ohio
Pandemics
phenotype
Phylogeny
Populations
risk
SARS-CoV-2 - genetics
Science
Science (multidisciplinary)
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
United States > US
Ohio
Online AccessGet full text

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Abstract The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock. White-tailed deer are an important reservoir of SARS-CoV-2 in the USA and continued monitoring of the virus in deer populations is needed. In this genomic epidemiology study from Ohio, the authors show that the virus has been introduced multiple times to deer from humans, and that it has evolved faster in deer.
AbstractList The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock. White-tailed deer are an important reservoir of SARS-CoV-2 in the USA and continued monitoring of the virus in deer populations is needed. In this genomic epidemiology study from Ohio, the authors show that the virus has been introduced multiple times to deer from humans, and that it has evolved faster in deer.
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.White-tailed deer are an important reservoir of SARS-CoV-2 in the USA and continued monitoring of the virus in deer populations is needed. In this genomic epidemiology study from Ohio, the authors show that the virus has been introduced multiple times to deer from humans, and that it has evolved faster in deer.
Abstract The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2–8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.
The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2-8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human hosts. Here, we detected that SARS-CoV-2 was introduced from humans into white-tailed deer more than 30 times in Ohio, USA during November 2021-March 2022. Subsequently, deer-to-deer transmission persisted for 2-8 months, disseminating across hundreds of kilometers. Newly developed Bayesian phylogenetic methods quantified how SARS-CoV-2 evolution is not only three-times faster in white-tailed deer compared to the rate observed in humans but also driven by different mutational biases and selection pressures. The long-term effect of this accelerated evolutionary rate remains to be seen as no critical phenotypic changes were observed in our animal models using white-tailed deer origin viruses. Still, SARS-CoV-2 has transmitted in white-tailed deer populations for a relatively short duration, and the risk of future changes may have serious consequences for humans and livestock.
ArticleNumber 5105
Author McBride, Dillon S.
Huey, Devra
Bowman, Andrew S.
Trifkovic, Sanja
Jeevan, Trushar
Franks, John
Genders, J. Tyler
Lenoch, Julianna B.
Miller, Lance
Kandeil, Ahmed
Patel, Anami
Magee, Andrew F.
Kasnyik, Kevin
Tonkovich, Michael J.
Linder, Timothy J.
Montoney, Andrew J.
Koonin, Eugene V.
Suchard, Marc A.
Webby, Richard J.
Faith, Seth A.
Williams, Amanda M.
Chandler, Jeffrey C.
DeLiberto, Thomas J.
Nelson, Martha I.
Garushyants, Sofya K.
Lemey, Philippe
Bevins, Sarah N.
Nolting, Jacqueline M.
Overend, Steven H.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/37640694$$D View this record in MEDLINE/PubMed
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Snippet The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in non-human...
Abstract The zoonotic origin of the COVID-19 pandemic virus highlights the need to fill the vast gaps in our knowledge of SARS-CoV-2 ecology and evolution in...
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Animal models
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Disease transmission
ecology
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Evolution
Humanities and Social Sciences
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long term effects
Mathematical models
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Odocoileus virginianus
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Pandemics
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Title Accelerated evolution of SARS-CoV-2 in free-ranging white-tailed deer
URI https://link.springer.com/article/10.1038/s41467-023-40706-y
https://www.ncbi.nlm.nih.gov/pubmed/37640694
https://www.proquest.com/docview/2858089312
https://www.proquest.com/docview/2858989777
https://www.proquest.com/docview/3153708942
https://pubmed.ncbi.nlm.nih.gov/PMC10462754
https://doaj.org/article/a94a05233273430581dbcc9e10313db9
Volume 14
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