Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults

Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary g...

Full description

Saved in:
Bibliographic Details
Published inNeuroImage (Orlando, Fla.) Vol. 275; p. 120167
Main Authors Damestani, Nikou L., Jacoby, John, Yadav, Shrikanth M., Lovely, Allison E., Michael, Aurea, Terpstra, Melissa, Eshghi, Marziye, Rashid, Barnaly, Cruchaga, Carlos, Salat, David H., Juttukonda, Meher R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.07.2023
Elsevier Limited
Elsevier
Subjects
Adult
Age
Aged
Aged, 80 and over
Aging
Aging - genetics
Alzheimer's disease
APOE
Apolipoprotein E
Apolipoproteins E - genetics
Arterial spin labeling
Arterial transit time
Blood flow
Blood pressure
Brain - physiology
Cerebral blood flow
Cerebrovascular Circulation - genetics
Cross-Sectional Studies
Female
Genotype
Genotype & phenotype
Genotypes
Healthy aging
Hemodynamics
Humans
Life span
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegenerative diseases
Perfusion
Perfusion MRI
Physiology
Regions
Risk factors
Sex
Sex differences
Spin Labels
ATT
Perfusion MRI
MRI
CBF
Sex differences
PLD
pCASL
TFCE
Cerebral blood flow
FDR
FWE
Arterial spin labeling
Aging
APOE
Healthy aging
Arterial transit time
HCP-A
Online AccessGet full text

Cover

Abstract Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOEε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
AbstractList Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer’s disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to > 90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOE ε 4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOE ε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOEε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOEε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOEε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
ArticleNumber 120167
Author Cruchaga, Carlos
Juttukonda, Meher R.
Damestani, Nikou L.
Michael, Aurea
Eshghi, Marziye
Salat, David H.
Rashid, Barnaly
Yadav, Shrikanth M.
Terpstra, Melissa
Jacoby, John
Lovely, Allison E.
AuthorAffiliation b Department of Radiology, Harvard Medical School, Boston, MA, USA
e Department of Neurology, Harvard Medical School, Boston, MA, USA
f Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
i Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston MA, USA
g NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA
a Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
d MGH Institute of Health Professions, Boston, MA, USA
c Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
h Hope Center for Neurologic Diseases, Washington University in St. Louis, St. Louis, MO, USA
AuthorAffiliation_xml – name: b Department of Radiology, Harvard Medical School, Boston, MA, USA
– name: c Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
– name: g NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, MO, USA
– name: h Hope Center for Neurologic Diseases, Washington University in St. Louis, St. Louis, MO, USA
– name: e Department of Neurology, Harvard Medical School, Boston, MA, USA
– name: f Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
– name: a Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– name: d MGH Institute of Health Professions, Boston, MA, USA
– name: i Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston MA, USA
Author_xml – sequence: 1
  givenname: Nikou L.
  orcidid: 0000-0002-0895-2589
  surname: Damestani
  fullname: Damestani, Nikou L.
  email: ndamestani@mgh.harvard.edu
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 2
  givenname: John
  surname: Jacoby
  fullname: Jacoby, John
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 3
  givenname: Shrikanth M.
  surname: Yadav
  fullname: Yadav, Shrikanth M.
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 4
  givenname: Allison E.
  surname: Lovely
  fullname: Lovely, Allison E.
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 5
  givenname: Aurea
  surname: Michael
  fullname: Michael, Aurea
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 6
  givenname: Melissa
  orcidid: 0000-0002-6249-1613
  surname: Terpstra
  fullname: Terpstra, Melissa
  organization: Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA
– sequence: 7
  givenname: Marziye
  surname: Eshghi
  fullname: Eshghi, Marziye
  organization: MGH Institute of Health Professions, Boston, MA, USA
– sequence: 8
  givenname: Barnaly
  orcidid: 0000-0002-3602-5109
  surname: Rashid
  fullname: Rashid, Barnaly
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 9
  givenname: Carlos
  orcidid: 0000-0002-0276-2899
  surname: Cruchaga
  fullname: Cruchaga, Carlos
  organization: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
– sequence: 10
  givenname: David H.
  surname: Salat
  fullname: Salat, David H.
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
– sequence: 11
  givenname: Meher R.
  orcidid: 0000-0001-9064-3648
  surname: Juttukonda
  fullname: Juttukonda, Meher R.
  email: mjuttukonda@mgh.harvard.edu
  organization: Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37187365$$D View this record in MEDLINE/PubMed
BookMark eNqFkk1v1DAQhi1URNuFv4AsceHQXfyV2DmhtipQqVI5wNly7EnWq6y92MnC_nscthTKBcmSrfE7z9gz7zk6CTEAQpiSFSW0frdZBZhS9FvTw4oRxleUlbh8hs4oaaplU0l2Mp8rvlSUNqfoPOcNIaShQr1Ap1xSJXldnaH1Zc7RejP6GDJuYfwOEHDBXuAMPy7w5ef7G9xDiONhV2ImOJygL2Iz4L3JdhpMwrv1Ifs4xP6AfcBF6a0ZhkPB-NBj46ZhzC_R884MGV497Av09cPNl-tPy7v7j7fXl3dLW0kxLkUDnROtbKVqgUvLqWW2kabuHFBKDLVEmMaITkju2kpSw2rVdC1zpFZS1XyBbo9cF81G71LpUTroaLz-FYip1yaN3g6gJasJay3UDDrRdkK5ilhnnClFHVeusN4fWbup3YKzEMZkhifQpzfBr3Uf95oSzpt5LdDbB0KK3ybIo976bGEYTIA4Zc0UFRWrGOVF-uYf6SZOqfR5VjHaiDLYGaiOKptizgm6x9dQomdv6I3-4w09e0MfvVFSX__9m8fE32YogqujAMp89h6SztZDsOB8AjuWBvr_V_kJCBHTTw
CitedBy_id crossref_primary_10_1016_j_nbd_2023_106323
crossref_primary_10_1002_jmri_29217
Cites_doi 10.1073/pnas.89.1.212
10.1006/cbmr.1996.0014
10.18632/aging.203482
10.3892/etm.2010.150
10.1016/j.nicl.2013.06.017
10.1161/01.STR.16.5.814
10.1002/mrm.10211
10.1371/journal.pone.0056733
10.1016/S1053-8119(03)00336-7
10.1371/journal.pgen.1001101
10.1016/j.neuroimage.2010.12.032
10.1016/j.neuroimage.2017.10.015
10.1016/j.neuroimage.2004.07.051
10.1002/mrm.20178
10.18632/oncotarget.5185
10.1016/j.neuroimage.2013.07.055
10.1016/j.neuroimage.2018.10.009
10.1002/ana.24135
10.1371/journal.pone.0183297
10.1006/nimg.1998.0395
10.1177/19714009211002778
10.1177/0271678X211021313
10.18632/aging.202673
10.1016/j.neuroimage.2009.06.060
10.1002/mrm.20023
10.1007/s00401-015-1522-0
10.1006/nimg.1998.0396
10.1016/j.neuroimage.2021.117807
10.1016/j.neuroimage.2006.01.021
10.1080/10543401003618819
10.3174/ajnr.A4828
10.1177/0271678X16683690
10.1016/j.neuroimage.2016.02.042
10.1002/jmri.25367
10.1016/j.neuroimage.2018.09.060
10.1016/j.arr.2014.02.002
10.1016/j.brainres.2018.12.030
10.1016/S0896-6273(02)00569-X
10.1002/hbm.24613
10.3233/JAD-121897
ContentType Journal Article
Copyright 2023
Copyright © 2023. Published by Elsevier Inc.
Copyright Elsevier Limited Jul 15, 2023
Copyright_xml – notice: 2023
– notice: Copyright © 2023. Published by Elsevier Inc.
– notice: Copyright Elsevier Limited Jul 15, 2023
DBID 6I.
AAFTH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7TK
7X7
7XB
88E
88G
8AO
8FD
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M2M
M7P
P64
PQEST
PQQKQ
PQUKI
PSYQQ
Q9U
RC3
7X8
5PM
DOA
DOI 10.1016/j.neuroimage.2023.120167
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Neurosciences Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
Psychology Database
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest One Psychology
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest One Psychology
ProQuest Central Student
Technology Research Database
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
Genetics Abstracts
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Psychology Journals (Alumni)
Biological Science Database
ProQuest SciTech Collection
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest Psychology Journals
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

MEDLINE

ProQuest One Psychology
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1095-9572
EndPage 120167
ExternalDocumentID oai_doaj_org_article_72602bce62ef4bf48d50cdada31cd38d
10_1016_j_neuroimage_2023_120167
37187365
S105381192300318X
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NIA NIH HHS
  grantid: K01 AG070318
– fundername: NIA NIH HHS
  grantid: R21 AG072068
– fundername: NIA NIH HHS
  grantid: U01 AG052564
– fundername: NIDCD NIH HHS
  grantid: K23 DC019179
GroupedDBID ---
--K
--M
.~1
0R~
123
1B1
1RT
1~.
1~5
4.4
457
4G.
5RE
5VS
6I.
7-5
71M
7X7
88E
8AO
8FE
8FH
8FI
8FJ
8P~
9JM
AABNK
AACTN
AADPK
AAEDW
AAFTH
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAXLA
AAXUO
ABBQC
ABCQJ
ABFNM
ABFRF
ABIVO
ABJNI
ABLVK
ABMAC
ABMZM
ABUWG
ABYKQ
ACDAQ
ACGFO
ACGFS
ACPRK
ACRLP
ADBBV
ADEZE
ADFRT
AEBSH
AEFWE
AEKER
AENEX
AFKRA
AFKWA
AFTJW
AFXIZ
AGUBO
AGWIK
AGYEJ
AHHHB
AHMBA
AIEXJ
AIKHN
AITUG
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
AXJTR
AZQEC
BBNVY
BENPR
BHPHI
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
C45
CCPQU
CS3
DM4
DU5
DWQXO
EBS
EFBJH
EO8
EO9
EP2
EP3
F5P
FDB
FIRID
FNPLU
FYGXN
FYUFA
G-Q
GBLVA
GNUQQ
GROUPED_DOAJ
HCIFZ
HMCUK
HMQ
IHE
J1W
KOM
LCYCR
LG5
LK8
LX8
M1P
M29
M2M
M2V
M41
M7P
MO0
MOBAO
N9A
NCXOZ
O-L
O9-
OAUVE
OK1
OVD
OZT
P-8
P-9
P2P
PC.
PQQKQ
PROAC
PSQYO
PSYQQ
Q38
RPZ
SAE
SCC
SDF
SDG
SDP
SES
SEW
SNS
SSH
SSN
SSZ
T5K
TEORI
UKHRP
UV1
YK3
ZA5
ZU3
~G-
.1-
.FO
0SF
AAEDT
AAXKI
ADVLN
AFJKZ
AFRHN
AJUYK
AKRWK
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
RIG
Z5R
29N
3V.
53G
AAQXK
AAYXX
ABXDB
ADFGL
ADMUD
AGHFR
AKRLJ
ASPBG
AVWKF
AZFZN
CAG
CITATION
COF
EJD
FEDTE
FGOYB
G-2
HDW
HEI
HMK
HMO
HVGLF
HZ~
R2-
ROL
WUQ
XPP
ZMT
7TK
7XB
8FD
8FK
FR3
K9.
P64
PQEST
PQUKI
Q9U
RC3
7X8
5PM
ID FETCH-LOGICAL-c574t-49efd4b7b78be37c31c2c97a6fde110a1c04a9a4f473db571a2689fb2d0687863
IEDL.DBID AIKHN
ISSN 1053-8119
1095-9572
IngestDate Tue Oct 22 15:15:18 EDT 2024
Tue Sep 17 21:30:34 EDT 2024
Sat Oct 26 04:55:08 EDT 2024
Thu Oct 10 22:04:33 EDT 2024
Thu Sep 26 19:48:35 EDT 2024
Sat Nov 02 12:21:14 EDT 2024
Fri Feb 23 02:37:08 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords ATT
Perfusion MRI
MRI
CBF
Sex differences
PLD
pCASL
TFCE
Cerebral blood flow
FDR
FWE
Arterial spin labeling
Aging
APOE
Healthy aging
Arterial transit time
HCP-A
Language English
License This is an open access article under the CC BY-NC-ND license.
Copyright © 2023. Published by Elsevier Inc.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c574t-49efd4b7b78be37c31c2c97a6fde110a1c04a9a4f473db571a2689fb2d0687863
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0002-0895-2589
0000-0002-0276-2899
0000-0002-6249-1613
0000-0002-3602-5109
0000-0001-9064-3648
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S105381192300318X
PMID 37187365
PQID 2821940959
PQPubID 2031077
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_72602bce62ef4bf48d50cdada31cd38d
pubmedcentral_primary_oai_pubmedcentral_nih_gov_10339339
proquest_miscellaneous_2814525213
proquest_journals_2821940959
crossref_primary_10_1016_j_neuroimage_2023_120167
pubmed_primary_37187365
elsevier_sciencedirect_doi_10_1016_j_neuroimage_2023_120167
PublicationCentury 2000
PublicationDate 2023-07-15
PublicationDateYYYYMMDD 2023-07-15
PublicationDate_xml – month: 07
  year: 2023
  text: 2023-07-15
  day: 15
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Amsterdam
PublicationTitle NeuroImage (Orlando, Fla.)
PublicationTitleAlternate Neuroimage
PublicationYear 2023
Publisher Elsevier Inc
Elsevier Limited
Elsevier
Publisher_xml – name: Elsevier Inc
– name: Elsevier Limited
– name: Elsevier
References Altmann, Tian, Henderson, Greicius (bib0002) 2014; 75
Harms, Somerville, Ances, Andersson, Barch, Bastiani, Bookheimer, Brown, Buckner, Burgess, Coalson, Chappell, Dapretto, Douaud, Fischl, Glasser, Greve, Hodge, Jamison, …, Yacoub (bib0017) 2018; 183
(accessed January 4, 2023).
Wang, Oh, Motovylyak, Ma, Sager, Rowley, Johnson, Gallagher, Carlsson, Bendlin, Johnson (bib0043) 2021
Juttukonda, Li, Almaktoum, Stephens, Yochim, Yacoub, Buckner, Salat (bib0021) 2021; 230
Mokhber, N., Shariatzadeh, A., Avan, A., Saber, H., Babaei, G.S., Chaimowitz, G. and Azarpazhooh, M.R., 2021. Cerebral blood flow changes during aging process and in cognitive disorders: a review. Neuroradiol. J., p. 19714009211002778. https://doi.org/10.1177/19714009211002778
Li, Wang, Wang, Tan (bib0023) 2021; 13
Wierenga, Clark, Dev, Shin, Jurick, Rissman, Liu, Bondi (bib0044) 2013; 34
Greve, Salat, Bowen, Izquierdo-Garcia, Schultz, Catana, Becker, Svarer, Knudsen, Sperling, Johnson (bib0015) 2016; 132
Mutsaerts, Petr, Václavů, van Dalen, Robertson, Caan, Masellis, Nederveen, Richard, MacIntosh (bib0030) 2017; 37
Lenth R.V., 2016. lsmeans: least-Squares Means version 2.30.0. R version 4.0.2
Markus, Allan, Ebmeier (bib0027) 2014
Alisch, Khattar, Kim, Cortina, Rejimon, Qian, Ferrucci, Resnick, Spencer, Bouhrara (bib0001) 2021; 13
Cox (bib0008) 1996; 29
Dale, Fischl, Sereno (bib0010) 1999; 9
Parkes, Rashid, Chard, Tofts (bib0032) 2004; 51
Xu, Moeller, Auerbach, Strupp, Smith, Feinberg, Yacoub, Uǧurbil (bib0046) 2013; 83
Smith, Jenkinson, Woolrich, Beckmann, Behrens, Johansen-Berg, Bannister, De Luca, Drobnjak, Flitney, Niazy (bib0038) 2004; 23
Chen, Rosas, Salat (bib0006) 2013; 8
Desikan, Ségonne, Fischl, Quinn, Dickerson, Blacker, Buckner, Dale, Maguire, Hyman, Albert (bib0011) 2006; 31
Cruchaga, Kauwe, Mayo, Spiegel, Bertelsen, Nowotny, Shah, Abraham, Hollingworth, Harold, Owen (bib0007) 2010; 6
Juttukonda, Donahue (bib0020) 2019; 187
Chen, Rosas, Salat (bib0005) 2011; 55
Fischl, Salat, Busa, Albert, Dieterich, Haselgrove, Van Der Kouwe, Killiany, Kennedy, Klaveness, Montillo (bib0014) 2002; 33
Staffaroni, Cobigo, Elahi, Casaletto, Walters, Wolf, Lindbergh, Rosen, Kramer (bib0039) 2019; 40
Rabinovici (bib0033) 2019; 25
Mathew, Wilson (bib0028) 1985; 16
Sampedro, Vilaplana, de Leon, Alcolea, Pegueroles, Montal, Carmona-Iragui, Sala, Sánchez-Saudinos, Antón-Aguirre, Morenas-Rodríguez, Camacho, Falcón, Pavía, Ros, Clarimón, Blesa, Lleó, Fortea (bib0036) 2015; 6
Dai, Fong, Jones, Marcantonio, Schmitt, Inouye, Alsop (bib0009) 2017; 45
Wang, Alger, Qiao, Gunther, Pope, Saver, Salamon, Liebeskind (bib0042) 2013; 3
Andersson, Skare, Ashburner (bib0003) 2003; 20
Mahlknecht, Kaiser (bib0026) 2010; 1
Wang, Alsop, Li, Listerud, Gonzalez-At, Schnall, Detre (bib0041) 2002; 48
Esposito, Van Horn, Weinberger, Berman (bib0012) 1996; 37
Greve, Fischl (bib0016) 2009; 48
.
OSIPI Task Force 4.1, 2022. ASL Lexicon. Available online at
Robertson, Beveridge, Bromley (bib0034) 2017; 12
Robison, Gannon, Salinero, Zuloaga (bib0035) 2019; 1710
Lu, Clingman, Golay, van Zijl (bib0025) 2004; 52
van Dalen, Mutsaerts, Nederveen, Vrenken, Steenwijk, Caan, Majoie, van Gool, Richard (bib0040) 2016; 37
Love, Miners (bib0024) 2016; 131
Bookheimer, Salat, Terpstra, Ances, Barch, Buckner, Burgess, Curtiss, Diaz-Santos, Elam, Fischl, Greve, Hagy, Harms, Hatch, Hedden, Hodge, Japardi, Kuhn, …, Yacoub (bib0004) 2019; 185
Singer, Trollor, Baune, Sachdev, Smith (bib0037) 2014; 15
Williams, Detre, Leigh, Koretsky (bib0045) 1992; 89
Fischl, Sereno, Dale (bib0013) 1999; 9
Heo, Leon (bib0018) 2010; 20
Mutsaerts (10.1016/j.neuroimage.2023.120167_bib0030) 2017; 37
Li (10.1016/j.neuroimage.2023.120167_bib0023) 2021; 13
Lu (10.1016/j.neuroimage.2023.120167_bib0025) 2004; 52
Bookheimer (10.1016/j.neuroimage.2023.120167_bib0004) 2019; 185
Staffaroni (10.1016/j.neuroimage.2023.120167_bib0039) 2019; 40
Juttukonda (10.1016/j.neuroimage.2023.120167_bib0020) 2019; 187
Robison (10.1016/j.neuroimage.2023.120167_bib0035) 2019; 1710
Esposito (10.1016/j.neuroimage.2023.120167_bib0012) 1996; 37
Fischl (10.1016/j.neuroimage.2023.120167_bib0013) 1999; 9
Cox (10.1016/j.neuroimage.2023.120167_bib0008) 1996; 29
Parkes (10.1016/j.neuroimage.2023.120167_bib0032) 2004; 51
Greve (10.1016/j.neuroimage.2023.120167_bib0015) 2016; 132
Rabinovici (10.1016/j.neuroimage.2023.120167_bib0033) 2019; 25
Andersson (10.1016/j.neuroimage.2023.120167_bib0003) 2003; 20
Mahlknecht (10.1016/j.neuroimage.2023.120167_bib0026) 2010; 1
Wierenga (10.1016/j.neuroimage.2023.120167_bib0044) 2013; 34
Markus (10.1016/j.neuroimage.2023.120167_bib0027) 2014
Alisch (10.1016/j.neuroimage.2023.120167_bib0001) 2021; 13
Robertson (10.1016/j.neuroimage.2023.120167_bib0034) 2017; 12
Sampedro (10.1016/j.neuroimage.2023.120167_bib0036) 2015; 6
Dai (10.1016/j.neuroimage.2023.120167_bib0009) 2017; 45
Cruchaga (10.1016/j.neuroimage.2023.120167_bib0007) 2010; 6
Singer (10.1016/j.neuroimage.2023.120167_bib0037) 2014; 15
Chen (10.1016/j.neuroimage.2023.120167_bib0006) 2013; 8
Desikan (10.1016/j.neuroimage.2023.120167_bib0011) 2006; 31
Juttukonda (10.1016/j.neuroimage.2023.120167_bib0021) 2021; 230
van Dalen (10.1016/j.neuroimage.2023.120167_bib0040) 2016; 37
10.1016/j.neuroimage.2023.120167_bib0022
Fischl (10.1016/j.neuroimage.2023.120167_bib0014) 2002; 33
10.1016/j.neuroimage.2023.120167_bib0029
Wang (10.1016/j.neuroimage.2023.120167_bib0042) 2013; 3
Wang (10.1016/j.neuroimage.2023.120167_bib0043) 2021
Love (10.1016/j.neuroimage.2023.120167_bib0024) 2016; 131
Heo (10.1016/j.neuroimage.2023.120167_bib0018) 2010; 20
Wang (10.1016/j.neuroimage.2023.120167_bib0041) 2002; 48
Altmann (10.1016/j.neuroimage.2023.120167_bib0002) 2014; 75
Chen (10.1016/j.neuroimage.2023.120167_bib0005) 2011; 55
Williams (10.1016/j.neuroimage.2023.120167_bib0045) 1992; 89
Smith (10.1016/j.neuroimage.2023.120167_bib0038) 2004; 23
Xu (10.1016/j.neuroimage.2023.120167_bib0046) 2013; 83
Mathew (10.1016/j.neuroimage.2023.120167_bib0028) 1985; 16
Dale (10.1016/j.neuroimage.2023.120167_bib0010) 1999; 9
Harms (10.1016/j.neuroimage.2023.120167_bib0017) 2018; 183
Greve (10.1016/j.neuroimage.2023.120167_bib0016) 2009; 48
10.1016/j.neuroimage.2023.120167_bib0031
References_xml – volume: 1
  start-page: 1019
  year: 2010
  end-page: 1025
  ident: bib0026
  article-title: Age-related changes in peripheral blood counts in humans
  publication-title: Exp. Ther. Med.
  contributor:
    fullname: Kaiser
– year: 2021
  ident: bib0043
  article-title: Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: a longitudinal study
  publication-title: J. Cereb. Blood Flow Metabol.
  contributor:
    fullname: Johnson
– volume: 89
  start-page: 212
  year: 1992
  end-page: 216
  ident: bib0045
  article-title: Magnetic resonance imaging of perfusion using spin inversion of arterial water
  publication-title: Proceed. Natl. Acad. Sci.
  contributor:
    fullname: Koretsky
– volume: 37
  start-page: 3184
  year: 2017
  end-page: 3192
  ident: bib0030
  article-title: The spatial coefficient of variation in arterial spin labeling cerebral blood flow images
  publication-title: J. Cereb. Blood Flow Metabol.
  contributor:
    fullname: MacIntosh
– volume: 45
  start-page: 472
  year: 2017
  end-page: 481
  ident: bib0009
  article-title: Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort
  publication-title: J. Magnet. Resonan. Imag.
  contributor:
    fullname: Alsop
– volume: 20
  start-page: 870
  year: 2003
  end-page: 888
  ident: bib0003
  article-title: How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging
  publication-title: Neuroimage
  contributor:
    fullname: Ashburner
– volume: 29
  start-page: 162
  year: 1996
  end-page: 173
  ident: bib0008
  article-title: AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
  publication-title: Comput. Biomed. Res.
  contributor:
    fullname: Cox
– volume: 31
  start-page: 968
  year: 2006
  end-page: 980
  ident: bib0011
  article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
  publication-title: Neuroimage
  contributor:
    fullname: Albert
– volume: 131
  start-page: 645
  year: 2016
  end-page: 658
  ident: bib0024
  article-title: Cerebrovascular disease in ageing and Alzheimer's disease
  publication-title: Acta Neuropathol.
  contributor:
    fullname: Miners
– volume: 83
  start-page: 991
  year: 2013
  end-page: 1001
  ident: bib0046
  article-title: Evaluation of slice accelerations using multiband echo planar imaging at 3 T
  publication-title: Neuroimage
  contributor:
    fullname: Uǧurbil
– volume: 13
  start-page: 21791
  year: 2021
  ident: bib0023
  article-title: Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach
  publication-title: Aging (Albany NY)
  contributor:
    fullname: Tan
– volume: 75
  start-page: 563
  year: 2014
  end-page: 573
  ident: bib0002
  article-title: Sex modifies the APOE-related risk of developing Alzheimer disease
  publication-title: Ann. Neurol.
  contributor:
    fullname: Greicius
– volume: 1710
  start-page: 43
  year: 2019
  end-page: 60
  ident: bib0035
  article-title: Contributions of sex to cerebrovascular function and pathology
  publication-title: Brain Res.
  contributor:
    fullname: Zuloaga
– volume: 55
  start-page: 468
  year: 2011
  end-page: 478
  ident: bib0005
  article-title: Age-associated reductions in cerebral blood flow are independent from regional atrophy
  publication-title: Neuroimage
  contributor:
    fullname: Salat
– volume: 51
  start-page: 736
  year: 2004
  end-page: 743
  ident: bib0032
  article-title: Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects
  publication-title: Magnet. Resonan. Med.: Off. J. Int. Soc. Magnet. Resonan. Med.
  contributor:
    fullname: Tofts
– volume: 23
  start-page: S208
  year: 2004
  end-page: S219
  ident: bib0038
  article-title: Advances in functional and structural MR image analysis and implementation as FSL
  publication-title: Neuroimage
  contributor:
    fullname: Niazy
– volume: 40
  start-page: 3522
  year: 2019
  end-page: 3533
  ident: bib0039
  article-title: A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure
  publication-title: Hum. Brain Mapp.
  contributor:
    fullname: Kramer
– volume: 230
  year: 2021
  ident: bib0021
  article-title: Characterizing cerebral hemodynamics across the adult lifespan with arterial spin labeling MRI data from the Human Connectome Project-Aging
  publication-title: Neuroimage
  contributor:
    fullname: Salat
– volume: 15
  start-page: 16
  year: 2014
  end-page: 27
  ident: bib0037
  article-title: Arterial stiffness, the brain and cognition: a systematic review
  publication-title: Ageing Res. Rev.
  contributor:
    fullname: Smith
– volume: 3
  start-page: 1
  year: 2013
  end-page: 7
  ident: bib0042
  article-title: Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke — Comparison with dynamic susceptibility contrast enhanced perfusion imaging
  publication-title: NeuroImage: Clin.
  contributor:
    fullname: Liebeskind
– volume: 25
  start-page: 14
  year: 2019
  end-page: 33
  ident: bib0033
  article-title: Late-onset Alzheimer Disease
  publication-title: Continuum (Minneap Minn)
  contributor:
    fullname: Rabinovici
– volume: 37
  start-page: 559
  year: 1996
  end-page: 564
  ident: bib0012
  article-title: Gender differences in cerebral blood flow as a function of cognitive state with PET
  publication-title: J. Nucl. Med.
  contributor:
    fullname: Berman
– volume: 6
  start-page: 26663
  year: 2015
  end-page: 26674
  ident: bib0036
  article-title: APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
  publication-title: Oncotarget
  contributor:
    fullname: Fortea
– volume: 6
  year: 2010
  ident: bib0007
  article-title: SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease
  publication-title: PLoS Genet.
  contributor:
    fullname: Owen
– volume: 16
  start-page: 814
  year: 1985
  end-page: 817
  ident: bib0028
  article-title: Caffeine induced changes in cerebral circulation
  publication-title: Stroke
  contributor:
    fullname: Wilson
– volume: 12
  year: 2017
  ident: bib0034
  article-title: Allostatic load as a predictor of all-cause and cause-specific mortality in the general population: evidence from the Scottish Health Survey
  publication-title: PLoS ONE
  contributor:
    fullname: Bromley
– volume: 13
  start-page: 4911
  year: 2021
  ident: bib0001
  article-title: Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging
  publication-title: Aging (Albany NY)
  contributor:
    fullname: Bouhrara
– volume: 9
  start-page: 179
  year: 1999
  end-page: 194
  ident: bib0010
  article-title: Cortical surface-based analysis: I. Segmentation and surface reconstruction
  publication-title: Neuroimage
  contributor:
    fullname: Sereno
– volume: 9
  start-page: 195
  year: 1999
  end-page: 207
  ident: bib0013
  article-title: Cortical surface-based analysis: II: Inflation, Flattening, and a surface-based coordinate system
  publication-title: Neuroimage
  contributor:
    fullname: Dale
– volume: 48
  start-page: 242
  year: 2002
  end-page: 254
  ident: bib0041
  article-title: Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla
  publication-title: Magnet. Resonan. Med.: Off. J. Int. Soc. Magnet. Resonan. Med.
  contributor:
    fullname: Detre
– volume: 20
  start-page: 787
  year: 2010
  end-page: 802
  ident: bib0018
  article-title: Sample sizes required to detect two-way and three-way interactions involving slope differences in mixed-effects linear models
  publication-title: J. Biopharm. Stat.
  contributor:
    fullname: Leon
– volume: 183
  start-page: 972
  year: 2018
  end-page: 984
  ident: bib0017
  article-title: Extending the human connectome project across ages: imaging protocols for the lifespan development and aging projects
  publication-title: Neuroimage
  contributor:
    fullname: Yacoub
– volume: 33
  start-page: 341
  year: 2002
  end-page: 355
  ident: bib0014
  article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain
  publication-title: Neuron
  contributor:
    fullname: Montillo
– volume: 187
  start-page: 192
  year: 2019
  end-page: 208
  ident: bib0020
  article-title: Neuroimaging of vascular reserve in patients with cerebrovascular diseases
  publication-title: Neuroimage
  contributor:
    fullname: Donahue
– start-page: 180
  year: 2014
  end-page: 191
  ident: bib0027
  publication-title: Cerebral Hemodynamics in Cerebral Small Vesseldisease
  contributor:
    fullname: Ebmeier
– volume: 48
  start-page: 63
  year: 2009
  end-page: 72
  ident: bib0016
  article-title: Accurate and robust brain image alignment using boundary-based registration
  publication-title: Neuroimage
  contributor:
    fullname: Fischl
– volume: 185
  start-page: 335
  year: 2019
  end-page: 348
  ident: bib0004
  article-title: The lifespan human connectome project in aging: an overview
  publication-title: Neuroimage
  contributor:
    fullname: Yacoub
– volume: 52
  start-page: 679
  year: 2004
  end-page: 682
  ident: bib0025
  article-title: Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla
  publication-title: Magn. Reson. Med.
  contributor:
    fullname: van Zijl
– volume: 34
  start-page: 921
  year: 2013
  end-page: 935
  ident: bib0044
  article-title: Interaction of age and APOE genotype on cerebral blood flow at rest
  publication-title: J. Alzheimer. Dis.
  contributor:
    fullname: Bondi
– volume: 8
  start-page: e56733
  year: 2013
  ident: bib0006
  article-title: The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span
  publication-title: PLoS ONE
  contributor:
    fullname: Salat
– volume: 132
  start-page: 334
  year: 2016
  end-page: 343
  ident: bib0015
  article-title: Different partial volume correction methods lead to different conclusions: an 18F-FDG-PET study of aging
  publication-title: Neuroimage
  contributor:
    fullname: Johnson
– volume: 37
  start-page: 1824
  year: 2016
  end-page: 1830
  ident: bib0040
  article-title: White matter hyperintensity volume and cerebral perfusion in older individuals with hypertension using arterial spin-labeling
  publication-title: Am. J. Neuroradiol.
  contributor:
    fullname: Richard
– volume: 89
  start-page: 212
  issue: 1
  year: 1992
  ident: 10.1016/j.neuroimage.2023.120167_bib0045
  article-title: Magnetic resonance imaging of perfusion using spin inversion of arterial water
  publication-title: Proceed. Natl. Acad. Sci.
  doi: 10.1073/pnas.89.1.212
  contributor:
    fullname: Williams
– volume: 29
  start-page: 162
  issue: 3
  year: 1996
  ident: 10.1016/j.neuroimage.2023.120167_bib0008
  article-title: AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
  publication-title: Comput. Biomed. Res.
  doi: 10.1006/cbmr.1996.0014
  contributor:
    fullname: Cox
– volume: 13
  start-page: 21791
  issue: 17
  year: 2021
  ident: 10.1016/j.neuroimage.2023.120167_bib0023
  article-title: Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.203482
  contributor:
    fullname: Li
– volume: 1
  start-page: 1019
  issue: 6
  year: 2010
  ident: 10.1016/j.neuroimage.2023.120167_bib0026
  article-title: Age-related changes in peripheral blood counts in humans
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2010.150
  contributor:
    fullname: Mahlknecht
– volume: 3
  start-page: 1
  year: 2013
  ident: 10.1016/j.neuroimage.2023.120167_bib0042
  article-title: Multi-delay multi-parametric arterial spin-labeled perfusion MRI in acute ischemic stroke — Comparison with dynamic susceptibility contrast enhanced perfusion imaging
  publication-title: NeuroImage: Clin.
  doi: 10.1016/j.nicl.2013.06.017
  contributor:
    fullname: Wang
– volume: 16
  start-page: 814
  issue: 5
  year: 1985
  ident: 10.1016/j.neuroimage.2023.120167_bib0028
  article-title: Caffeine induced changes in cerebral circulation
  publication-title: Stroke
  doi: 10.1161/01.STR.16.5.814
  contributor:
    fullname: Mathew
– volume: 48
  start-page: 242
  issue: 2
  year: 2002
  ident: 10.1016/j.neuroimage.2023.120167_bib0041
  article-title: Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla
  publication-title: Magnet. Resonan. Med.: Off. J. Int. Soc. Magnet. Resonan. Med.
  doi: 10.1002/mrm.10211
  contributor:
    fullname: Wang
– volume: 8
  start-page: e56733
  issue: 2
  year: 2013
  ident: 10.1016/j.neuroimage.2023.120167_bib0006
  article-title: The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0056733
  contributor:
    fullname: Chen
– volume: 20
  start-page: 870
  issue: 2
  year: 2003
  ident: 10.1016/j.neuroimage.2023.120167_bib0003
  article-title: How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging
  publication-title: Neuroimage
  doi: 10.1016/S1053-8119(03)00336-7
  contributor:
    fullname: Andersson
– volume: 37
  start-page: 559
  issue: 4
  year: 1996
  ident: 10.1016/j.neuroimage.2023.120167_bib0012
  article-title: Gender differences in cerebral blood flow as a function of cognitive state with PET
  publication-title: J. Nucl. Med.
  contributor:
    fullname: Esposito
– ident: 10.1016/j.neuroimage.2023.120167_bib0022
– volume: 25
  start-page: 14
  year: 2019
  ident: 10.1016/j.neuroimage.2023.120167_bib0033
  article-title: Late-onset Alzheimer Disease
  publication-title: Continuum (Minneap Minn)
  contributor:
    fullname: Rabinovici
– volume: 6
  issue: 9
  year: 2010
  ident: 10.1016/j.neuroimage.2023.120167_bib0007
  article-title: SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1001101
  contributor:
    fullname: Cruchaga
– volume: 55
  start-page: 468
  issue: 2
  year: 2011
  ident: 10.1016/j.neuroimage.2023.120167_bib0005
  article-title: Age-associated reductions in cerebral blood flow are independent from regional atrophy
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2010.12.032
  contributor:
    fullname: Chen
– volume: 187
  start-page: 192
  year: 2019
  ident: 10.1016/j.neuroimage.2023.120167_bib0020
  article-title: Neuroimaging of vascular reserve in patients with cerebrovascular diseases
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2017.10.015
  contributor:
    fullname: Juttukonda
– volume: 23
  start-page: S208
  year: 2004
  ident: 10.1016/j.neuroimage.2023.120167_bib0038
  article-title: Advances in functional and structural MR image analysis and implementation as FSL
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2004.07.051
  contributor:
    fullname: Smith
– volume: 52
  start-page: 679
  issue: 3
  year: 2004
  ident: 10.1016/j.neuroimage.2023.120167_bib0025
  article-title: Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla
  publication-title: Magn. Reson. Med.
  doi: 10.1002/mrm.20178
  contributor:
    fullname: Lu
– volume: 6
  start-page: 26663
  issue: 29
  year: 2015
  ident: 10.1016/j.neuroimage.2023.120167_bib0036
  article-title: APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5185
  contributor:
    fullname: Sampedro
– volume: 83
  start-page: 991
  year: 2013
  ident: 10.1016/j.neuroimage.2023.120167_bib0046
  article-title: Evaluation of slice accelerations using multiband echo planar imaging at 3 T
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2013.07.055
  contributor:
    fullname: Xu
– volume: 185
  start-page: 335
  year: 2019
  ident: 10.1016/j.neuroimage.2023.120167_bib0004
  article-title: The lifespan human connectome project in aging: an overview
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.10.009
  contributor:
    fullname: Bookheimer
– volume: 75
  start-page: 563
  issue: 4
  year: 2014
  ident: 10.1016/j.neuroimage.2023.120167_bib0002
  article-title: Sex modifies the APOE-related risk of developing Alzheimer disease
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.24135
  contributor:
    fullname: Altmann
– volume: 12
  issue: 8
  year: 2017
  ident: 10.1016/j.neuroimage.2023.120167_bib0034
  article-title: Allostatic load as a predictor of all-cause and cause-specific mortality in the general population: evidence from the Scottish Health Survey
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0183297
  contributor:
    fullname: Robertson
– volume: 9
  start-page: 179
  issue: 2
  year: 1999
  ident: 10.1016/j.neuroimage.2023.120167_bib0010
  article-title: Cortical surface-based analysis: I. Segmentation and surface reconstruction
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0395
  contributor:
    fullname: Dale
– ident: 10.1016/j.neuroimage.2023.120167_bib0029
  doi: 10.1177/19714009211002778
– year: 2021
  ident: 10.1016/j.neuroimage.2023.120167_bib0043
  article-title: Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: a longitudinal study
  publication-title: J. Cereb. Blood Flow Metabol.
  doi: 10.1177/0271678X211021313
  contributor:
    fullname: Wang
– volume: 13
  start-page: 4911
  issue: 4
  year: 2021
  ident: 10.1016/j.neuroimage.2023.120167_bib0001
  article-title: Sex and age-related differences in cerebral blood flow investigated using pseudo-continuous arterial spin labeling magnetic resonance imaging
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.202673
  contributor:
    fullname: Alisch
– volume: 48
  start-page: 63
  issue: 1
  year: 2009
  ident: 10.1016/j.neuroimage.2023.120167_bib0016
  article-title: Accurate and robust brain image alignment using boundary-based registration
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2009.06.060
  contributor:
    fullname: Greve
– volume: 51
  start-page: 736
  issue: 4
  year: 2004
  ident: 10.1016/j.neuroimage.2023.120167_bib0032
  article-title: Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects
  publication-title: Magnet. Resonan. Med.: Off. J. Int. Soc. Magnet. Resonan. Med.
  doi: 10.1002/mrm.20023
  contributor:
    fullname: Parkes
– volume: 131
  start-page: 645
  issue: 5
  year: 2016
  ident: 10.1016/j.neuroimage.2023.120167_bib0024
  article-title: Cerebrovascular disease in ageing and Alzheimer's disease
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-015-1522-0
  contributor:
    fullname: Love
– ident: 10.1016/j.neuroimage.2023.120167_bib0031
– volume: 9
  start-page: 195
  issue: 2
  year: 1999
  ident: 10.1016/j.neuroimage.2023.120167_bib0013
  article-title: Cortical surface-based analysis: II: Inflation, Flattening, and a surface-based coordinate system
  publication-title: Neuroimage
  doi: 10.1006/nimg.1998.0396
  contributor:
    fullname: Fischl
– volume: 230
  year: 2021
  ident: 10.1016/j.neuroimage.2023.120167_bib0021
  article-title: Characterizing cerebral hemodynamics across the adult lifespan with arterial spin labeling MRI data from the Human Connectome Project-Aging
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2021.117807
  contributor:
    fullname: Juttukonda
– volume: 31
  start-page: 968
  issue: 3
  year: 2006
  ident: 10.1016/j.neuroimage.2023.120167_bib0011
  article-title: An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2006.01.021
  contributor:
    fullname: Desikan
– volume: 20
  start-page: 787
  issue: 4
  year: 2010
  ident: 10.1016/j.neuroimage.2023.120167_bib0018
  article-title: Sample sizes required to detect two-way and three-way interactions involving slope differences in mixed-effects linear models
  publication-title: J. Biopharm. Stat.
  doi: 10.1080/10543401003618819
  contributor:
    fullname: Heo
– volume: 37
  start-page: 1824
  issue: 10
  year: 2016
  ident: 10.1016/j.neuroimage.2023.120167_bib0040
  article-title: White matter hyperintensity volume and cerebral perfusion in older individuals with hypertension using arterial spin-labeling
  publication-title: Am. J. Neuroradiol.
  doi: 10.3174/ajnr.A4828
  contributor:
    fullname: van Dalen
– volume: 37
  start-page: 3184
  issue: 9
  year: 2017
  ident: 10.1016/j.neuroimage.2023.120167_bib0030
  article-title: The spatial coefficient of variation in arterial spin labeling cerebral blood flow images
  publication-title: J. Cereb. Blood Flow Metabol.
  doi: 10.1177/0271678X16683690
  contributor:
    fullname: Mutsaerts
– volume: 132
  start-page: 334
  year: 2016
  ident: 10.1016/j.neuroimage.2023.120167_bib0015
  article-title: Different partial volume correction methods lead to different conclusions: an 18F-FDG-PET study of aging
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2016.02.042
  contributor:
    fullname: Greve
– volume: 45
  start-page: 472
  issue: 2
  year: 2017
  ident: 10.1016/j.neuroimage.2023.120167_bib0009
  article-title: Effects of arterial transit delay on cerebral blood flow quantification using arterial spin labeling in an elderly cohort
  publication-title: J. Magnet. Resonan. Imag.
  doi: 10.1002/jmri.25367
  contributor:
    fullname: Dai
– volume: 183
  start-page: 972
  year: 2018
  ident: 10.1016/j.neuroimage.2023.120167_bib0017
  article-title: Extending the human connectome project across ages: imaging protocols for the lifespan development and aging projects
  publication-title: Neuroimage
  doi: 10.1016/j.neuroimage.2018.09.060
  contributor:
    fullname: Harms
– volume: 15
  start-page: 16
  year: 2014
  ident: 10.1016/j.neuroimage.2023.120167_bib0037
  article-title: Arterial stiffness, the brain and cognition: a systematic review
  publication-title: Ageing Res. Rev.
  doi: 10.1016/j.arr.2014.02.002
  contributor:
    fullname: Singer
– volume: 1710
  start-page: 43
  year: 2019
  ident: 10.1016/j.neuroimage.2023.120167_bib0035
  article-title: Contributions of sex to cerebrovascular function and pathology
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2018.12.030
  contributor:
    fullname: Robison
– volume: 33
  start-page: 341
  issue: 3
  year: 2002
  ident: 10.1016/j.neuroimage.2023.120167_bib0014
  article-title: Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain
  publication-title: Neuron
  doi: 10.1016/S0896-6273(02)00569-X
  contributor:
    fullname: Fischl
– start-page: 180
  year: 2014
  ident: 10.1016/j.neuroimage.2023.120167_bib0027
  publication-title: Cerebral Hemodynamics in Cerebral Small Vesseldisease
  contributor:
    fullname: Markus
– volume: 40
  start-page: 3522
  issue: 12
  year: 2019
  ident: 10.1016/j.neuroimage.2023.120167_bib0039
  article-title: A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure
  publication-title: Hum. Brain Mapp.
  doi: 10.1002/hbm.24613
  contributor:
    fullname: Staffaroni
– volume: 34
  start-page: 921
  issue: 4
  year: 2013
  ident: 10.1016/j.neuroimage.2023.120167_bib0044
  article-title: Interaction of age and APOE genotype on cerebral blood flow at rest
  publication-title: J. Alzheimer. Dis.
  doi: 10.3233/JAD-121897
  contributor:
    fullname: Wierenga
SSID ssj0009148
Score 2.486645
Snippet Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 120167
SubjectTerms Adult
Age
Aged
Aged, 80 and over
Aging
Aging - genetics
Alzheimer's disease
APOE
Apolipoprotein E
Apolipoproteins E - genetics
Arterial spin labeling
Arterial transit time
Blood flow
Blood pressure
Brain - physiology
Cerebral blood flow
Cerebrovascular Circulation - genetics
Cross-Sectional Studies
Female
Genotype
Genotype & phenotype
Genotypes
Healthy aging
Hemodynamics
Humans
Life span
Magnetic Resonance Imaging
Male
Middle Aged
Neurodegenerative diseases
Perfusion
Perfusion MRI
Physiology
Regions
Risk factors
Sex
Sex differences
Spin Labels
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQD4gL4k2gRUbiuClx7PihntqqVYVU4ECl3iw_1UU0RexWgn_PjJMsGzjAASmXJM7Knm-8_jwefUPIG6AcwjkDCKgcawE7lNrpLtRK5yy0i8kVBb7z9_LsQry77C63Sn1hTtggDzwY7q0Cwt36kGSbsvDwfeyaEF10nIXIdSz_vo2ZNlOT3C6w_DFvZ8jmKuqQy2uYo_tYMHyftZh_P1uMimb_bE36k3P-njq5tRadPiD3RxJJD4fOPyR3Uv-I3D0fj8kfk6sto6_omIpFoVcLukrfF_Tw44cTiuqsGIBdUNdHigUakJTTKTWVlphHCbrTZU-hJcL55QctZY1o0e1YPSEXpyefjs_qsaRCHTol1rUwKUfhlVfaJ64CGLENRjmZYwIi4FhohDNOZKF49J1irpXaZN_GRmqlJX9KdvqbPj0H23LY6-jgG56kMFkaA5h7oRzccp1kRdhkW_t1UM6wU0rZZ_sLD4t42AGPihwhCJv2qH1dHoBH2NEj7N88oiIHE4R2pBEDPYCfWv5DF3Yn1O04nVcW9qXMCAyZVuT15jVMRDxdcX26ucU2DM-IW8Yr8mxwks04ODAAxWVXET1zn9lA52_65VUR-2YN5wauF__DNC_JPRwqxqZZt0t21t9u0x6QqrV_VebPT11YJFY
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3daxQxEA9aQXwpfrtaJYKPt3WzyeYDH6RKSxGqPli4t5BPe6J7bfcK-t87yWbvegoi7MtuwpLkN7P5zWR2BqFXQDmYMQoQENHXDCyU2sjO1ULGyKTxweQMfCcf-fEp-zDv5sXhNpSwyumbmD_UfumSj_w1mAZgbyev1dvzizpVjUqnq6WExk10i7QNTyFdYi42SXcJG3-F62gtCVElkmeM78r5Ihc_QGv3UwnxfXgBydXmN9tTzuK_tUv9zUL_DKa8tjsd3UW7hVbig1EO7qEbob-Pbp-Ug_MH6OwaDAMuwVkYRjXDQ_g5wwefPx3ilK81uWRn2PQep5INiabjKVgVZy9IdsPjRY-hZwL4-y-cCx3hnMljeIhOjw6_vD-uS5GF2nWCrWqmQvTMCiukDVQ4SlzrlDA8-gDUwBDXMKMMi0xQbztBTMulirb1sN5CcvoI7fTLPjyBtaVg_UhnGxo4U5ErBVJgmTBwS2XgFSLT2urzMZeGnoLMvukNHjrhoUc8KvQugbDun7Jh5wfLy6-6KJcWYJS11gXehsgsyJjvGueNNzAZT6Wv0JsJQl2IxUgY4FWL_xjC3oS6Lgo-6I04VujluhlUM523mD4sr1Ifkk6NW0Ir9HgUkvU8KHACQXlXIbklPlsT3W7pF2c5_TdpKFVwPf33uJ6hO2kSyQ9Nuj20s7q8Cs-BQK3si6wlvwGGWxw4
  priority: 102
  providerName: ProQuest
Title Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults
URI https://dx.doi.org/10.1016/j.neuroimage.2023.120167
https://www.ncbi.nlm.nih.gov/pubmed/37187365
https://www.proquest.com/docview/2821940959
https://www.proquest.com/docview/2814525213
https://pubmed.ncbi.nlm.nih.gov/PMC10339339
https://doaj.org/article/72602bce62ef4bf48d50cdada31cd38d
Volume 275
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELe2TkK8IL4JjMpIPDZtHTv-EE_d1KmAViZgUt8sJ3ZYEKTT2knwwt_O2XG6BV6QkKJESZwo59_Z9_P5ckboNVAOZowCBERlUwYjlNTIvEyFrComjXUmZOA7XfLFOXu3yld76Lj7F8aHVca-v-3TQ28dr0xibU4u63ryCZgBmBvPUIJmrvbRAZijTA7Qwezt-8XyJvcuYe0fcTlN_QMxoKcN8wppI-vv0HjHfiXxMcl8YH7PSoVk_j1j9TcZ_TOm8paROrmP7kV2iWetAA_Qnmseojuncf78Ebq4hcYGxxgtDF81whv3Y4RnZx_m2Kdt9Z7ZETaNxX7lBs_WcRezioMzJHjjcd1gKOlx_vYTh_WOcEjosXmMzk_mn48XaVxrIS1zwbYpU66yrBCFkIWjoqSkzEolDK-sA4ZgSDllRhlWMUFtkQtiMi5VVWR2yqWQnD5Bg2bduGdQtxQGQbIsptRxpiquFChDwYSBUyodTxDp6lZftik1dBdr9lXf4KE9HrrFI0FHHoRdeZ8UO1xYX33RUSu0gLFZVpSOZ65iBaiazaelNdaAMJZKm6A3HYS6p2PwqvofPuGwQ13Hdr7RMGAlinlfaoJe7W5DC_XTLqZx62tfhvjJ44zQBD1tlWQnBwVqICjPEyR76tMTtH-nqS9CFnAypVTB9vy_pHqB7voz760m-SEabK-u3UugWdtiiPbHvwjsxUoMY5OC49F8efZxGFwXvwFDIS1E
link.rule.ids 230,315,783,787,867,888,2109,4509,12068,21400,24128,27936,27937,31731,31732,33756,33757,43322,43817,45597,45691,74073,74630
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3fb9MwELZgSLAXxG8CA4zEYzPi2Ilt8YAG2lRgHTxsUt8sJ3ZY0UjH0knw33PnOO0CEkLqSxursvPdxd-dL98R8gooh7BWAwKycamACCW1qqhTqZpGKOu8DQp8s6NyeiI-zot5TLh1saxyeCaGB7Vb1pgjfw2hAcTbmLV6e_4jxa5ReLoaW2hcJzdQhws7GMi53IjuMtG_ClfwVDGmYyVPX98V9CIX38Frd7GF-C7LsSJ_tD0FFf_RLvU3C_2zmPLK7nRwh9yOtJLu9XZwl1zz7T1ycxYPzu-T0yswdDQWZ1GY1YR2_ueE7n35vE9RrxVTshNqW0exZQPSdDoUq9KQBQlpeLpoKYxEgM9-0dDoiAYlj-4BOTnYP34_TWOThbQupFilQvvGiUpWUlWey5qzOq-1tGXjPFADy-pMWG1FIyR3VSGZzUulmyp3WamkKvlDstUuW_8Y7i2H6EfVVcZ9KXRTag1WUAlp4StXvkwIG-6tOe-1NMxQZPbNbPAwiIfp8UjIOwRhPR7VsMMPy4uvJjqXkRCU5VXty9w3ogIbc0VWO-ssLMZx5RLyZoDQRGLREwb4q8V_TGFnQN1EB-_MxhwT8nJ9GVwTz1ts65eXOIbhqXHOeEIe9UayXgcHTiB5WSREjcxntNDxlXZxGuS_Wca5hs-Tf8_rBbk1PZ4dmsMPR5-ekm1cEOakWbFDtlYXl_4ZkKlV9Tx4zG_xGh8f
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELagSBUXxLspBYzEcdPGseOHOKACXZVHSw9U2pvl2A5dRLOl2Urw7xk7zm4DEkLay26slZ1vJp4Zf_kGoZcQcjBjFCAgGpczyFByIyubC9k0TBrnTVTgOzrmh6fsw6yaJf5Tl2iVwzMxPqjdwoYa-R6kBpBvh6rVXpNoESfvpq8vfuShg1Q4aU3tNG6iWwKylGDzYibWAryE9a_FVTSXhKjE6um5XlE7cn4OHrwb2onvkjKw80dbVVT0H-1Yf0ekfxIrr-1U07voTgox8X5vE_fQDd_eR5tH6RD9ATq7BkmHE1ELw6wmuPM_J3j_5PMBDtqtoTw7waZ1OLRvCCE7HoirOFZEYkkez1sMIwPY33_h2PQIR1WP7iE6nR58eXuYp4YLua0EW-ZM-caxWtRC1p4KS4ktrRKGN85DmGCILZhRhjVMUFdXgpiSS9XUpSu4FJLTR2ijXbR-C-4thUxI2rqgnjPVcKXAImomDHyl0vMMkeHe6oteV0MPhLNveo2HDnjoHo8MvQkgrMYHZez4w-Lyq06OpgUkaGVtPS99w2qwN1cV1hlnYDGOSpehVwOEOgUZffAAfzX_jynsDKjr5OydXptmhl6sLoObhrMX0_rFVRhDwglySWiGHvdGsloHhfhAUF5lSI7MZ7TQ8ZV2fhalwElBqYLP9r_n9RxtgrPoT--PPz5Bt8N6QnmaVDtoY3l55Z9CXLWsn0WH-Q1qGSNX
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Associations+between+age%2C+sex%2C+APOE+genotype%2C+and+regional+vascular+physiology+in+typically+aging+adults&rft.jtitle=NeuroImage+%28Orlando%2C+Fla.%29&rft.au=Damestani%2C+Nikou+L.&rft.au=Jacoby%2C+John&rft.au=Yadav%2C+Shrikanth+M.&rft.au=Lovely%2C+Allison+E.&rft.date=2023-07-15&rft.pub=Elsevier+Inc&rft.issn=1053-8119&rft.eissn=1095-9572&rft.volume=275&rft_id=info:doi/10.1016%2Fj.neuroimage.2023.120167&rft.externalDocID=S105381192300318X
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1053-8119&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1053-8119&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1053-8119&client=summon