Cancer risk across mammals

Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations 1 , 2 . While elevated cancer risk with larger body size and/or longevity has been doc...

Full description

Saved in:
Bibliographic Details
Published inNature (London) Vol. 601; no. 7892; pp. 263 - 267
Main Authors Vincze, Orsolya, Colchero, Fernando, Lemaître, Jean-Francois, Conde, Dalia A., Pavard, Samuel, Bieuville, Margaux, Urrutia, Araxi O., Ujvari, Beata, Boddy, Amy M., Maley, Carlo C., Thomas, Frédéric, Giraudeau, Mathieu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.01.2022
Nature Publishing Group
Subjects
631/181
631/601
631/67
Age
Aging
Animals
Animals, Zoo - classification
Aquariums
Aùimals, Zoo
Bias
Birth control
Body mass
Body Size
Body Weight
Cancer
Carcinogens
Carnivory
Cell cycle
Cell division
Diet - veterinary
Empirical analysis
Evolution
Health risks
Humanities and Social Sciences
Life expectancy
Life history
Life Sciences
Life span
Longevity
Mammals
Mammals - classification
Mortality
Mortality risk
multidisciplinary
Mutation
Neoplasms
Neoplasms - mortality
Neoplasms - pathology
Neoplasms - veterinary
Paradoxes
Phylogenetics
Phylogeny
Risk
Risk Factors
Science
Science (multidisciplinary)
Species
Species Specificity
Online AccessGet full text

Cover

Abstract Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations 1 , 2 . While elevated cancer risk with larger body size and/or longevity has been documented within species 3 – 5 , Peto’s paradox indicates the apparent lack of such an association among taxa 6 . Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences. An analysis of cancer mortality data for zoo mammals highlights marked differences across mammalian orders and an influence of diet, and shows that mortality risk is largely independent of body mass and life expectancy across species.
AbstractList Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations 1 , 2 . While elevated cancer risk with larger body size and/or longevity has been documented within species 3 – 5 , Peto’s paradox indicates the apparent lack of such an association among taxa 6 . Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences. An analysis of cancer mortality data for zoo mammals highlights marked differences across mammalian orders and an influence of diet, and shows that mortality risk is largely independent of body mass and life expectancy across species.
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations 1,2 . While elevated cancer risk with larger body size and/or longevity has been documented within species 3–5 , Peto’s paradox indicates the apparent lack of such an association among taxa 6 . Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations . While elevated cancer risk with larger body size and/or longevity has been documented within species , Peto's paradox indicates the apparent lack of such an association among taxa . Yet, unequivocal empirical evidence for Peto's paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto's paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations 1,2 . While elevated cancer risk with larger body size and/or longevity has been documented within species 3–5 , Peto’s paradox indicates the apparent lack of such an association among taxa 6 . Yet, unequivocal empirical evidence for Peto’s paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto’s paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species3-5, Peto's paradox indicates the apparent lack of such an association among taxa6. Yet, unequivocal empirical evidence for Peto's paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto's paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species3-5, Peto's paradox indicates the apparent lack of such an association among taxa6. Yet, unequivocal empirical evidence for Peto's paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto's paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell divisions, and thus increased probability of somatic mutations1,2. While elevated cancer risk with larger body size and/or longevity has been documented within species3-5, Peto's paradox indicates the apparent lack of such an association among taxa6. Yet, unequivocal empirical evidence for Peto's paradox is lacking, stemming from the difficulty of estimating cancer risk in non-model species. Here we build and analyse a database on cancer-related mortality using data on adult zoo mammals (110,148 individuals, 191 species) and map age-controlled cancer mortality to the mammalian tree of life. We demonstrate the universality and high frequency of oncogenic phenomena in mammals and reveal substantial differences in cancer mortality across major mammalian orders. We show that the phylogenetic distribution of cancer mortality is associated with diet, with carnivorous mammals (especially mammal-consuming ones) facing the highest cancer-related mortality. Moreover, we provide unequivocal evidence for the body size and longevity components of Peto's paradox by showing that cancer mortality risk is largely independent of both body mass and adult life expectancy across species. These results highlight the key role of life-history evolution in shaping cancer resistance and provide major advancements in the quest for natural anticancer defences.
Author Conde, Dalia A.
Ujvari, Beata
Giraudeau, Mathieu
Vincze, Orsolya
Colchero, Fernando
Maley, Carlo C.
Lemaître, Jean-Francois
Pavard, Samuel
Urrutia, Araxi O.
Bieuville, Margaux
Boddy, Amy M.
Thomas, Frédéric
Author_xml – sequence: 1
  givenname: Orsolya
  orcidid: 0000-0001-5789-2124
  surname: Vincze
  fullname: Vincze, Orsolya
  email: vincze.orsolya@ecolres.hu
  organization: CREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD, Littoral, Environnement et Sociétés (LIENSs), UMR 7266 CNRS-La Rochelle Université, Institute of Aquatic Ecology, Centre for Ecological Research, Evolutionary Ecology Group, Hungarian Department of Biology and Ecology, Babeş-Bolyai University
– sequence: 2
  givenname: Fernando
  orcidid: 0000-0001-8613-4568
  surname: Colchero
  fullname: Colchero, Fernando
  organization: Department of Mathematics and Computer Science, University of Southern Denmark, Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Species360 Conservation Science Alliance
– sequence: 3
  givenname: Jean-Francois
  surname: Lemaître
  fullname: Lemaître, Jean-Francois
  organization: Laboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon 1; CNRS,UMR5558
– sequence: 4
  givenname: Dalia A.
  orcidid: 0000-0002-7923-8163
  surname: Conde
  fullname: Conde, Dalia A.
  organization: Interdisciplinary Centre on Population Dynamics, University of Southern Denmark, Species360 Conservation Science Alliance, Department of Biology, University of Southern Denmark
– sequence: 5
  givenname: Samuel
  surname: Pavard
  fullname: Pavard, Samuel
  organization: Eco-Anthropologie (EA), Muséum National d’Histoire Naturelle, CNRS, Université de Paris, Musée de l’Homme
– sequence: 6
  givenname: Margaux
  surname: Bieuville
  fullname: Bieuville, Margaux
  organization: Eco-Anthropologie (EA), Muséum National d’Histoire Naturelle, CNRS, Université de Paris, Musée de l’Homme
– sequence: 7
  givenname: Araxi O.
  surname: Urrutia
  fullname: Urrutia, Araxi O.
  organization: Instituto de Ecologia, UNAM, Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath
– sequence: 8
  givenname: Beata
  orcidid: 0000-0003-2391-2988
  surname: Ujvari
  fullname: Ujvari, Beata
  organization: Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University
– sequence: 9
  givenname: Amy M.
  surname: Boddy
  fullname: Boddy, Amy M.
  organization: Department of Anthropology, University of California Santa Barbara
– sequence: 10
  givenname: Carlo C.
  orcidid: 0000-0002-0745-7076
  surname: Maley
  fullname: Maley, Carlo C.
  organization: Arizona Cancer Evolution Center, Biodesign Institute and School of Life Sciences, Arizona State University
– sequence: 11
  givenname: Frédéric
  orcidid: 0000-0003-2238-1978
  surname: Thomas
  fullname: Thomas, Frédéric
  organization: CREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD
– sequence: 12
  givenname: Mathieu
  surname: Giraudeau
  fullname: Giraudeau, Mathieu
  organization: CREEC/CANECEV, MIVEGEC (CREES), University of Montpellier, CNRS, IRD, Littoral, Environnement et Sociétés (LIENSs), UMR 7266 CNRS-La Rochelle Université
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34937938$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03527342$$DView record in HAL
BookMark eNp9kUtPWzEQhS0EIg_4AyyqSN2UxaVje_zaVEJRC0iR2NC15Ti-cOE-UvsGiX9fJxcozQJvRvJ8Z2Z0zoQctl0bCDmjcEGB6-8JqdCyAEYLQMawEAdkTFHJAqVWh2QMwHQBmssRmaT0CACCKjwmI46GK8P1mJzNXetDnMUqPc2cj11Ks8Y1javTCTkqcwmnr3VKfv_6eTe_Lha3Vzfzy0XhhcK-4AZCGfhScyEM4qr0bCnRKS6ZcUEaiswvlSlL8FLpIBGoENI4J8qVw1LzKfkxzF1vlk1Y-dD20dV2HavGxRfbucr-32mrB3vfPVuthBBc5gHnw4CHPdn15cJu_4ALpjiyZ5rZb6_LYvdnE1Jvmyr5UNeuDd0mWSYpZ4Zv35R83UMfu01ssxWZYoCgUWCmvny8_n3_m8UZYAOwMzeG8h2hYLc52iFHm3O0uxytyCK9J_JV7_qq2zpQ1Z9L-SBNeU97H-K_sz9R_QURp650
CitedBy_id crossref_primary_10_1126_sciadv_adm7273
crossref_primary_10_3390_vetsci11100485
crossref_primary_10_1038_s41467_024_47264_x
crossref_primary_10_1007_s00239_023_10092_6
crossref_primary_10_1002_zoo_21802
crossref_primary_10_1039_D4RA06517D
crossref_primary_10_1186_s12862_022_02096_5
crossref_primary_10_3390_genes13081496
crossref_primary_10_1021_jacs_2c09967
crossref_primary_10_1093_emph_eoae011
crossref_primary_10_3389_fcell_2024_1377073
crossref_primary_10_1002_mco2_174
crossref_primary_10_3389_frym_2023_1006057
crossref_primary_10_1016_j_biochi_2022_10_014
crossref_primary_10_1093_emph_eoae016
crossref_primary_10_1073_pnas_2422861122
crossref_primary_10_1038_s43587_022_00231_x
crossref_primary_10_1098_rspb_2023_0940
crossref_primary_10_1134_S0006297924603575
crossref_primary_10_3390_app12115748
crossref_primary_10_1080_10717544_2023_2183830
crossref_primary_10_1073_pnas_2302147120
crossref_primary_10_1146_annurev_animal_050322_074744
crossref_primary_10_3389_fvets_2024_1313182
crossref_primary_10_1007_s10654_022_00933_x
crossref_primary_10_1016_j_cytogfr_2024_09_002
crossref_primary_10_7202_1095222ar
crossref_primary_10_1158_2159_8290_CD_24_0573
crossref_primary_10_3389_fsci_2023_997136
crossref_primary_10_1101_gr_278930_124
crossref_primary_10_3390_nu14194166
crossref_primary_10_1038_s41598_024_62425_0
crossref_primary_10_1093_evolut_qpae158
crossref_primary_10_1038_s41392_022_01122_8
crossref_primary_10_1038_s41586_022_04618_z
crossref_primary_10_1158_2159_8290_CD_24_1539
crossref_primary_10_3389_fimmu_2024_1320779
crossref_primary_10_1590_1678_4685_gmb_2022_0133
crossref_primary_10_1111_acel_13709
crossref_primary_10_1007_s10911_025_09578_4
crossref_primary_10_1126_sciadv_abj7176
crossref_primary_10_3390_life13071478
crossref_primary_10_1016_j_arr_2024_102268
crossref_primary_10_1016_j_bj_2023_100697
crossref_primary_10_1158_2643_3230_BCD_23_0272
crossref_primary_10_1093_emph_eoac040
crossref_primary_10_3390_vetsci11110521
crossref_primary_10_5802_crbiol_159
crossref_primary_10_1042_EBC20220041
crossref_primary_10_1098_rspb_2023_2655
crossref_primary_10_3390_ijms252413671
crossref_primary_10_1007_s10654_023_01090_5
crossref_primary_10_1098_rsos_231356
crossref_primary_10_3390_vetsci9110611
crossref_primary_10_22175_mmb_15762
crossref_primary_10_2139_ssrn_4105881
crossref_primary_10_3390_pathogens11020241
crossref_primary_10_3390_vetsci9100535
crossref_primary_10_1038_s41467_024_49106_2
crossref_primary_10_1177_15330338221123109
crossref_primary_10_1002_bies_202200188
crossref_primary_10_1016_j_pbiomolbio_2024_07_001
crossref_primary_10_1038_s41467_024_45767_1
crossref_primary_10_1053_j_gastro_2022_07_081
crossref_primary_10_1002_ijc_34987
crossref_primary_10_1016_j_ajcnut_2024_04_029
crossref_primary_10_1128_mmbr_00022_21
crossref_primary_10_1051_medsci_2022098
crossref_primary_10_1002_adma_202300692
crossref_primary_10_1016_j_bj_2023_100596
crossref_primary_10_1681_ASN_0000000582
crossref_primary_10_1016_j_neubiorev_2023_105400
crossref_primary_10_7554_eLife_78335
crossref_primary_10_7554_eLife_82558
crossref_primary_10_1007_s11357_022_00653_w
crossref_primary_10_1038_s41568_022_00447_4
crossref_primary_10_1016_j_scitotenv_2024_175785
crossref_primary_10_1086_724384
crossref_primary_10_1111_nyas_15233
crossref_primary_10_1051_medsci_2024038
crossref_primary_10_1186_s13059_023_02851_x
crossref_primary_10_3390_fractalfract8010035
crossref_primary_10_3389_fevo_2022_861103
crossref_primary_10_3389_fimmu_2024_1414376
crossref_primary_10_26873_SVR_2180_2024
crossref_primary_10_3390_cancers15010027
crossref_primary_10_1007_s00239_024_10204_w
crossref_primary_10_1017_S0022029923000110
crossref_primary_10_1038_d41586_022_00976_w
crossref_primary_10_1016_j_jtbi_2024_111958
crossref_primary_10_1016_j_tig_2023_08_005
crossref_primary_10_1158_2159_8290_CD_22_0504
crossref_primary_10_1007_s00285_024_02123_7
crossref_primary_10_1007_s00239_024_10222_8
crossref_primary_10_1177_01466453221142702
crossref_primary_10_1016_j_bj_2023_100654
crossref_primary_10_1002_aac2_12046
crossref_primary_10_3389_fimmu_2023_1192907
crossref_primary_10_3390_genes14020329
crossref_primary_10_1016_j_medj_2022_07_005
crossref_primary_10_1038_s42003_023_05034_3
crossref_primary_10_1093_molbev_msae160
crossref_primary_10_1038_s41467_025_57344_1
crossref_primary_10_3389_fevo_2025_1489294
Cites_doi 10.1093/bioinformatics/btg412
10.1111/eva.12018
10.1093/molbev/msaa285
10.1098/rstb.2014.0177
10.1111/1365-2435.13474
10.1111/j.1939-1676.2011.0695.x
10.1111/j.2041-210X.2011.00169.x
10.1098/rspb.1999.0664
10.1126/science.347.6217.12
10.1073/pnas.1816367116
10.1002/ece3.1136
10.1038/s41568-018-0045-0
10.3233/BD-2007-28102
10.1001/jama.293.2.172
10.1371/journal.pbio.3000494
10.3390/ani10122376
10.1098/rspb.2018.1743
10.1038/srep36361
10.1111/jeb.13060
10.1093/molbev/msab127
10.1126/science.1138275
10.1126/science.1155725
10.1038/nrc1016
10.1093/ije/dyv199
10.1001/jama.2015.13134
10.1038/nature22975
10.1111/brv.12415
10.1038/s41568-018-0004-9
10.1016/j.tree.2011.01.002
10.1038/s41559-018-0558-7
10.1038/bjc.1954.1
10.1093/sysbio/syy060
10.1134/S0026893319050030
10.1093/bioinformatics/btq228
10.1186/s13027-020-00314-7
10.1890/10-0340.1
10.1007/s10552-013-0317-7
10.1002/em.22087
10.1093/emph/eoaa015
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer Nature Limited 2021
2021. The Author(s), under exclusive licence to Springer Nature Limited.
Copyright Nature Publishing Group Jan 13, 2022
Attribution
Copyright_xml – notice: The Author(s), under exclusive licence to Springer Nature Limited 2021
– notice: 2021. The Author(s), under exclusive licence to Springer Nature Limited.
– notice: Copyright Nature Publishing Group Jan 13, 2022
– notice: Attribution
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QG
7QL
7QP
7QR
7RV
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7X2
7X7
7XB
88A
88E
88G
88I
8AF
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BEC
BENPR
BGLVJ
BHPHI
BKSAR
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M2M
M2O
M2P
M7N
M7P
M7S
MBDVC
NAPCQ
P5Z
P62
P64
PATMY
PCBAR
PDBOC
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PSYQQ
PTHSS
PYCSY
Q9U
R05
RC3
S0X
SOI
7X8
1XC
VOOES
5PM
DOI 10.1038/s41586-021-04224-5
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Nursing & Allied Health Database
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
eLibrary Curriculum
ProQuest Central
Technology Collection
Natural Science Collection
Earth, Atmospheric & Aquatic Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Materials Science Collection
ProQuest Central Korea
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agricultural Science Database
Health & Medical Collection (Alumni)
Medical Database
Psychology Database
Research Library
Science Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
ProQuest Engineering Database
Research Library (Corporate)
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
ProQuest Earth, Atmospheric & Aquatic Science Database (NC LIVE)
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
Engineering collection
Environmental Science Collection
ProQuest Central Basic
University of Michigan
Genetics Abstracts
SIRS Editorial
Environment Abstracts
MEDLINE - Academic
Hyper Article en Ligne (HAL)
Hyper Article en Ligne (HAL) (Open Access)
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
ProQuest One Psychology
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Earth, Atmospheric & Aquatic Science Database
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
University of Michigan
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
SIRS Editorial
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Earth, Atmospheric & Aquatic Science Collection
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Research Library
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList


MEDLINE
CrossRef
Agricultural Science Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Physics
EISSN 1476-4687
EndPage 267
ExternalDocumentID PMC8755536
oai_HAL_hal_03527342v1
34937938
10_1038_s41586_021_04224_5
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: U2C CA233254
– fundername: NCI NIH HHS
  grantid: U54 CA217376
GroupedDBID ---
--Z
-DZ
-ET
-~X
.55
.CO
.XZ
07C
0R~
0WA
123
186
1OL
1VR
29M
2KS
2XV
39C
41X
53G
5RE
6TJ
70F
7RV
7X2
7X7
7XC
85S
88A
88E
88I
8AF
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
8G5
8R4
8R5
8WZ
97F
97L
A6W
A7Z
AAEEF
AAHBH
AAHTB
AAIKC
AAKAB
AAMNW
AASDW
AAVBQ
AAYEP
AAYZH
AAZLF
ABDQB
ABFSI
ABIVO
ABJCF
ABJNI
ABLJU
ABOCM
ABPEJ
ABPPZ
ABUWG
ABWJO
ABZEH
ACBEA
ACBWK
ACGFO
ACGFS
ACGOD
ACIWK
ACKOT
ACMJI
ACNCT
ACPRK
ACWUS
ADBBV
ADFRT
ADUKH
AENEX
AEUYN
AFBBN
AFFNX
AFKRA
AFLOW
AFRAH
AFSHS
AGAYW
AGHSJ
AGHTU
AGOIJ
AGSOS
AHMBA
AHSBF
AIDUJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARAPS
ARMCB
ASPBG
ATCPS
ATWCN
AVWKF
AXYYD
AZFZN
AZQEC
BBNVY
BCU
BEC
BENPR
BGLVJ
BHPHI
BIN
BKEYQ
BKKNO
BKSAR
BPHCQ
BVXVI
C6C
CCPQU
CJ0
CS3
D1I
D1J
D1K
DU5
DWQXO
E.-
E.L
EAP
EBS
EE.
EMH
EPS
EX3
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
HCIFZ
HG6
HMCUK
HVGLF
HZ~
IAO
ICQ
IEA
IEP
IGS
IH2
IHR
INH
INR
IOF
IPY
ISR
K6-
KB.
KOO
L6V
L7B
LK5
LK8
LSO
M0K
M1P
M2M
M2O
M2P
M7P
M7R
M7S
N9A
NAPCQ
NEPJS
O9-
OBC
OES
OHH
OMK
OVD
P2P
P62
PATMY
PCBAR
PDBOC
PKN
PQQKQ
PROAC
PSQYO
PSYQQ
PTHSS
PYCSY
Q2X
R05
RND
RNS
RNT
RNTTT
RXW
S0X
SC5
SHXYY
SIXXV
SJFOW
SJN
SNYQT
SOJ
TAE
TAOOD
TBHMF
TDRGL
TEORI
TN5
TSG
TWZ
U5U
UIG
UKHRP
UKR
UMD
UQL
VQA
VVN
WH7
WOW
X7M
XIH
XKW
XZL
Y6R
YAE
YCJ
YFH
YIF
YIN
YNT
YOC
YQT
YR2
YR5
YXB
YZZ
Z5M
ZCA
~02
~7V
~88
~KM
AARCD
AAYXX
ABFSG
ACMFV
ACSTC
AEZWR
AFANA
AFHIU
AHWEU
AIXLP
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
.-4
.GJ
.HR
00M
08P
1CY
1VW
354
3EH
3O-
4.4
41~
42X
4R4
663
79B
9M8
A8Z
AAJYS
AAKAS
AAYOK
ABAWZ
ABDBF
ABDPE
ABEFU
ABMOR
ABNNU
ABTAH
ACBNA
ACBTR
ACRPL
ACTDY
ACUHS
ADNMO
ADRHT
ADYSU
ADZCM
AETEA
AFFDN
AFHKK
AGCDD
AGGDT
AGNAY
AIDAL
AIYXT
AJUXI
APEBS
ARTTT
B0M
BCR
BDKGC
BES
BKOMP
BLC
CGR
CUY
CVF
DB5
DO4
EAD
EAS
EAZ
EBC
EBD
EBO
ECC
ECM
EIF
EJD
EMB
EMF
EMK
EMOBN
EPL
ESE
ESN
ESX
FA8
FAC
I-F
ITC
J5H
L-9
LGEZI
LOTEE
MVM
N4W
NADUK
NEJ
NFIDA
NPM
NXXTH
ODYON
OHT
P-O
PEA
PM3
PV9
QS-
R4F
RHI
SKT
SV3
TH9
TUD
TUS
UAO
UBY
UHB
USG
VOH
X7L
XOL
YJ6
YQI
YQJ
YV5
YXA
YYP
YYQ
ZCG
ZE2
ZGI
ZHY
ZKB
ZKG
ZY4
~8M
~G0
3V.
7QG
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
KL.
M7N
MBDVC
P64
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
PUEGO
Q9U
RC3
SOI
7X8
1XC
PMFND
VOOES
5PM
ID FETCH-LOGICAL-c574t-390efe3b8355944dfc2b64a73629ae69142cb79ff0c678e64015569aa5fda4f83
IEDL.DBID 8FG
ISSN 0028-0836
1476-4687
IngestDate Thu Aug 21 18:23:19 EDT 2025
Sat Jun 07 06:21:01 EDT 2025
Tue Aug 05 10:28:20 EDT 2025
Sat Aug 23 14:22:52 EDT 2025
Thu Apr 03 06:52:32 EDT 2025
Tue Jul 01 02:32:32 EDT 2025
Thu Apr 24 23:10:18 EDT 2025
Fri Feb 21 02:38:43 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7892
Language English
License 2021. The Author(s), under exclusive licence to Springer Nature Limited.
Attribution: http://creativecommons.org/licenses/by
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c574t-390efe3b8355944dfc2b64a73629ae69142cb79ff0c678e64015569aa5fda4f83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
PMCID: PMC8755536
ORCID 0000-0003-2238-1978
0000-0003-2391-2988
0000-0001-8613-4568
0000-0002-7923-8163
0000-0001-5789-2124
0000-0002-0745-7076
0000-0001-9898-2353
0000-0002-6803-8123
0000-0002-4741-5575
0000-0001-9011-8675
0000-0001-8563-1810
OpenAccessLink https://www.nature.com/articles/s41586-021-04224-5
PMID 34937938
PQID 2620408454
PQPubID 40569
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8755536
hal_primary_oai_HAL_hal_03527342v1
proquest_miscellaneous_2613293333
proquest_journals_2620408454
pubmed_primary_34937938
crossref_primary_10_1038_s41586_021_04224_5
crossref_citationtrail_10_1038_s41586_021_04224_5
springer_journals_10_1038_s41586_021_04224_5
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-01-13
PublicationDateYYYYMMDD 2022-01-13
PublicationDate_xml – month: 01
  year: 2022
  text: 2022-01-13
  day: 13
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationSubtitle International weekly journal of science
PublicationTitle Nature (London)
PublicationTitleAbbrev Nature
PublicationTitleAlternate Nature
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Paradis, Claude, Strimmer (CR44) 2004; 20
Tollis (CR18) 2021; 38
Kelly, Ikonomou, Blair, Morin, Gobas (CR28) 2007; 317
Leroi, Koufopanou, Burt (CR1) 2003; 3
Pesavento, Agnew, Keel, Woolard (CR29) 2018; 18
Kissling (CR32) 2014; 4
CR39
Ives (CR43) 2018; 68
Chatterjee, Walker (CR8) 2017; 58
Seluanov, Gladyshev, Vijg, Gorbunova (CR35) 2018; 18
Fleming, Creevy, Promislow (CR4) 2011; 25
Giraudeau, Sepp, Ujvari, Ewald, Thomas (CR38) 2018; 2
Nunney (CR11) 2018; 285
Revell (CR22) 2012; 3
Olival (CR33) 2017; 546
CR10
Wirén (CR3) 2014; 25
Møller, Erritzøe, Soler (CR16) 2017; 30
Chao (CR27) 2005; 293
Armitage, Doll (CR2) 1954; 8
Peto (CR14) 2016; 45
Herrera-Álvarez, Karlsson, Ryder, Lindblad-Toh, Crawford (CR36) 2021; 38
Ronget, Gaillard (CR20) 2020; 34
Harrenstien (CR25) 1996; 27
Nunney (CR9) 2013; 6
Caulin, Maley (CR12) 2011; 26
Boddy (CR15) 2020; 2020
Nunney (CR5) 1999; 266
Ley (CR34) 2008; 320
Tidière (CR21) 2016; 6
CR6
Couzin-Frankel (CR7) 2015; 347
Nunney, Maley, Breen, Hochberg, Schiffman (CR13) 2015; 370
Khatami (CR31) 2020; 15
Bogolyubova (CR30) 2019; 53
Albuquerque, Drummond do Val, Doherty, de Magalhães (CR37) 2018; 93
Abegglen (CR17) 2015; 314
CR47
CR24
CR46
Munson, Moresco (CR26) 2007; 28
Conde (CR19) 2019; 116
CR40
Moresco (CR23) 2020; 10
Sukumaran, Holder (CR42) 2010; 26
Upham, Esselstyn, Jetz (CR41) 2019; 17
Warton, Hui (CR45) 2011; 92
4224_CR10
E Paradis (4224_CR44) 2004; 20
RE Ley (4224_CR34) 2008; 320
AM Leroi (4224_CR1) 2003; 3
AF Caulin (4224_CR12) 2011; 26
DA Conde (4224_CR19) 2019; 116
L Nunney (4224_CR5) 1999; 266
J Sukumaran (4224_CR42) 2010; 26
A Khatami (4224_CR31) 2020; 15
S Herrera-Álvarez (4224_CR36) 2021; 38
PA Pesavento (4224_CR29) 2018; 18
M Tidière (4224_CR21) 2016; 6
P Armitage (4224_CR2) 1954; 8
L Nunney (4224_CR9) 2013; 6
LJ Revell (4224_CR22) 2012; 3
4224_CR39
NS Upham (4224_CR41) 2019; 17
N Chatterjee (4224_CR8) 2017; 58
V Ronget (4224_CR20) 2020; 34
L Munson (4224_CR26) 2007; 28
S Wirén (4224_CR3) 2014; 25
R Peto (4224_CR14) 2016; 45
TAF Albuquerque (4224_CR37) 2018; 93
BC Kelly (4224_CR28) 2007; 317
M Tollis (4224_CR18) 2021; 38
L Nunney (4224_CR11) 2018; 285
AV Bogolyubova (4224_CR30) 2019; 53
LM Abegglen (4224_CR17) 2015; 314
4224_CR40
LA Harrenstien (4224_CR25) 1996; 27
4224_CR6
AP Møller (4224_CR16) 2017; 30
M Giraudeau (4224_CR38) 2018; 2
JM Fleming (4224_CR4) 2011; 25
A Moresco (4224_CR23) 2020; 10
L Nunney (4224_CR13) 2015; 370
A Chao (4224_CR27) 2005; 293
AM Boddy (4224_CR15) 2020; 2020
WD Kissling (4224_CR32) 2014; 4
A Seluanov (4224_CR35) 2018; 18
KJ Olival (4224_CR33) 2017; 546
J Couzin-Frankel (4224_CR7) 2015; 347
DI Warton (4224_CR45) 2011; 92
4224_CR47
4224_CR24
AR Ives (4224_CR43) 2018; 68
4224_CR46
35102282 - Nat Rev Cancer. 2022 Mar;22(3):129
References_xml – volume: 20
  start-page: 289
  year: 2004
  end-page: 290
  ident: CR44
  article-title: APE: Analyses of Phylogenetics and Evolution in R language
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btg412
– ident: CR47
– volume: 6
  start-page: 11
  year: 2013
  end-page: 19
  ident: CR9
  article-title: The real war on cancer: the evolutionary dynamics of cancer suppression
  publication-title: Evol. Appl.
  doi: 10.1111/eva.12018
– volume: 27
  start-page: 468
  year: 1996
  end-page: 476
  ident: CR25
  article-title: Mammary cancer in captive wild felids and risk factors for its development: a retrospective study of the clinical behavior of 31 cases
  publication-title: J. Zoo Wildl. Med.
– volume: 38
  start-page: 1715
  year: 2021
  end-page: 1730
  ident: CR36
  article-title: How to make a rodent giant: genomic basis and tradeoffs of gigantism in the capybara, the world’s largest rodent
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msaa285
– volume: 370
  start-page: 20140177
  year: 2015
  ident: CR13
  article-title: Peto’s paradox and the promise of comparative oncology
  publication-title: Philos. Trans. R. Soc. B
  doi: 10.1098/rstb.2014.0177
– volume: 34
  start-page: 65
  year: 2020
  end-page: 75
  ident: CR20
  article-title: Assessing ageing patterns for comparative analyses of mortality curves: going beyond the use of maximum longevity
  publication-title: Funct. Ecol.
  doi: 10.1111/1365-2435.13474
– ident: CR39
– volume: 25
  start-page: 187
  year: 2011
  end-page: 198
  ident: CR4
  article-title: Mortality in North American dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death
  publication-title: J. Vet. Intern. Med.
  doi: 10.1111/j.1939-1676.2011.0695.x
– volume: 3
  start-page: 217
  year: 2012
  end-page: 223
  ident: CR22
  article-title: phytools: an R package for phylogenetic comparative biology (and other things)
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/j.2041-210X.2011.00169.x
– volume: 266
  start-page: 493
  year: 1999
  end-page: 498
  ident: CR5
  article-title: Lineage selection and the evolution of multistage carcinogenesis
  publication-title: Proc. R. Soc. B
  doi: 10.1098/rspb.1999.0664
– volume: 347
  start-page: 12
  year: 2015
  ident: CR7
  article-title: The bad luck of cancer
  publication-title: Science
  doi: 10.1126/science.347.6217.12
– ident: CR10
– volume: 116
  start-page: 9658
  year: 2019
  end-page: 9664
  ident: CR19
  article-title: Data gaps and opportunities for comparative and conservation biology
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1816367116
– volume: 4
  start-page: 2913
  year: 2014
  end-page: 2930
  ident: CR32
  article-title: Establishing macroecological trait datasets: digitalization, extrapolation, and validation of diet preferences in terrestrial mammals worldwide
  publication-title: Ecol. Evol.
  doi: 10.1002/ece3.1136
– ident: CR6
– volume: 18
  start-page: 646
  year: 2018
  end-page: 661
  ident: CR29
  article-title: Cancer in wildlife: patterns of emergence
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0045-0
– volume: 28
  start-page: 7
  year: 2007
  end-page: 21
  ident: CR26
  article-title: Comparative pathology of mammary gland cancers in domestic and wild animals
  publication-title: Breast Disease
  doi: 10.3233/BD-2007-28102
– volume: 293
  start-page: 172
  year: 2005
  end-page: 182
  ident: CR27
  article-title: Meat consumption and risk of colorectal cancer
  publication-title: JAMA
  doi: 10.1001/jama.293.2.172
– volume: 17
  start-page: e3000494
  year: 2019
  ident: CR41
  article-title: Inferring the mammal tree: species-level sets of phylogenies for questions in ecology, evolution, and conservation
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.3000494
– volume: 10
  start-page: 2376
  year: 2020
  ident: CR23
  article-title: Taxonomic distribution of neoplasia among non-domestic felid species under managed care
  publication-title: Animals
  doi: 10.3390/ani10122376
– ident: CR40
– volume: 285
  start-page: 20181743
  year: 2018
  ident: CR11
  article-title: Size matters: height, cell number and a person’s risk of cancer
  publication-title: Proc. R. Soc. B
  doi: 10.1098/rspb.2018.1743
– volume: 6
  year: 2016
  ident: CR21
  article-title: Comparative analyses of longevity and senescence reveal variable survival benefits of living in zoos across mammals
  publication-title: Sci. Rep.
  doi: 10.1038/srep36361
– volume: 30
  start-page: 960
  year: 2017
  end-page: 967
  ident: CR16
  article-title: Life history, immunity, Peto’s paradox and tumours in birds
  publication-title: J. Evol. Biol.
  doi: 10.1111/jeb.13060
– volume: 38
  start-page: 3606
  year: 2021
  end-page: 3620
  ident: CR18
  article-title: Elephant genomes reveal accelerated evolution in mechanisms underlying disease defenses
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msab127
– volume: 317
  start-page: 236
  year: 2007
  end-page: 239
  ident: CR28
  article-title: Food web-specific biomagnification of persistent organic pollutants
  publication-title: Science
  doi: 10.1126/science.1138275
– volume: 320
  start-page: 1647
  year: 2008
  end-page: 1651
  ident: CR34
  article-title: Evolution of mammals and their gut microbes
  publication-title: Science
  doi: 10.1126/science.1155725
– volume: 3
  start-page: 226
  year: 2003
  end-page: 231
  ident: CR1
  article-title: Cancer selection
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1016
– ident: CR46
– volume: 45
  start-page: 621
  year: 2016
  end-page: 637
  ident: CR14
  article-title: Epidemiology, multistage models, and short-term mutagenicity tests
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyv199
– volume: 314
  start-page: 1850
  year: 2015
  end-page: 1860
  ident: CR17
  article-title: Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans
  publication-title: JAMA
  doi: 10.1001/jama.2015.13134
– volume: 546
  start-page: 646
  year: 2017
  end-page: 650
  ident: CR33
  article-title: Host and viral traits predict zoonotic spillover from mammals
  publication-title: Nature
  doi: 10.1038/nature22975
– volume: 93
  start-page: 1715
  year: 2018
  end-page: 1734
  ident: CR37
  article-title: From humans to hydra: patterns of cancer across the tree of life
  publication-title: Biol. Rev.
  doi: 10.1111/brv.12415
– volume: 18
  start-page: 433
  year: 2018
  end-page: 441
  ident: CR35
  article-title: Mechanisms of cancer resistance in long-lived mammals
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0004-9
– volume: 26
  start-page: 175
  year: 2011
  end-page: 182
  ident: CR12
  article-title: Peto’s paradox: evolution’s prescription for cancer prevention
  publication-title: Trends Ecol. Evol.
  doi: 10.1016/j.tree.2011.01.002
– volume: 2
  start-page: 1065
  year: 2018
  end-page: 1070
  ident: CR38
  article-title: Human activities might influence oncogenic processes in wild animal populations
  publication-title: Nat. Ecol. Evol.
  doi: 10.1038/s41559-018-0558-7
– volume: 8
  start-page: 1
  year: 1954
  end-page: 12
  ident: CR2
  article-title: The age distribution of cancer and a multi-stage theory of carcinogenesis
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1954.1
– volume: 68
  start-page: 234
  year: 2018
  end-page: 251
  ident: CR43
  article-title: R s for correlated data: phylogenetic models, LMMs, and GLMMs
  publication-title: Syst. Biol.
  doi: 10.1093/sysbio/syy060
– volume: 53
  start-page: 767
  year: 2019
  end-page: 775
  ident: CR30
  article-title: Human oncogenic viruses: old facts and new hypotheses
  publication-title: Mol. Biol.
  doi: 10.1134/S0026893319050030
– volume: 26
  start-page: 1569
  year: 2010
  end-page: 1571
  ident: CR42
  article-title: DendroPy: a Python library for phylogenetic computing
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq228
– volume: 15
  start-page: 48
  year: 2020
  ident: CR31
  article-title: Bovine leukemia virus (BLV) and risk of breast cancer: a systematic review and meta-analysis of case-control studies
  publication-title: Infect. Agents Cancer
  doi: 10.1186/s13027-020-00314-7
– volume: 92
  start-page: 3
  year: 2011
  end-page: 10
  ident: CR45
  article-title: The arcsine is asinine: the analysis of proportions in ecology
  publication-title: Ecology
  doi: 10.1890/10-0340.1
– ident: CR24
– volume: 25
  start-page: 151
  year: 2014
  end-page: 159
  ident: CR3
  article-title: Pooled cohort study on height and risk of cancer and cancer death
  publication-title: Cancer Causes Control
  doi: 10.1007/s10552-013-0317-7
– volume: 58
  start-page: 235
  year: 2017
  end-page: 263
  ident: CR8
  article-title: Mechanisms of DNA damage, repair, and mutagenesis
  publication-title: Environ. Mol. Mutagen.
  doi: 10.1002/em.22087
– volume: 2020
  start-page: 187
  year: 2020
  end-page: 195
  ident: CR15
  article-title: Lifetime cancer prevalence and life history traits in mammals
  publication-title: Evol. Med. Public Health
  doi: 10.1093/emph/eoaa015
– volume: 92
  start-page: 3
  year: 2011
  ident: 4224_CR45
  publication-title: Ecology
  doi: 10.1890/10-0340.1
– volume: 116
  start-page: 9658
  year: 2019
  ident: 4224_CR19
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1816367116
– volume: 2020
  start-page: 187
  year: 2020
  ident: 4224_CR15
  publication-title: Evol. Med. Public Health
  doi: 10.1093/emph/eoaa015
– volume: 38
  start-page: 3606
  year: 2021
  ident: 4224_CR18
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msab127
– volume: 15
  start-page: 48
  year: 2020
  ident: 4224_CR31
  publication-title: Infect. Agents Cancer
  doi: 10.1186/s13027-020-00314-7
– volume: 293
  start-page: 172
  year: 2005
  ident: 4224_CR27
  publication-title: JAMA
  doi: 10.1001/jama.293.2.172
– volume: 370
  start-page: 20140177
  year: 2015
  ident: 4224_CR13
  publication-title: Philos. Trans. R. Soc. B
  doi: 10.1098/rstb.2014.0177
– volume: 8
  start-page: 1
  year: 1954
  ident: 4224_CR2
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1954.1
– volume: 6
  start-page: 11
  year: 2013
  ident: 4224_CR9
  publication-title: Evol. Appl.
  doi: 10.1111/eva.12018
– volume: 38
  start-page: 1715
  year: 2021
  ident: 4224_CR36
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msaa285
– volume: 320
  start-page: 1647
  year: 2008
  ident: 4224_CR34
  publication-title: Science
  doi: 10.1126/science.1155725
– volume: 3
  start-page: 226
  year: 2003
  ident: 4224_CR1
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1016
– volume: 4
  start-page: 2913
  year: 2014
  ident: 4224_CR32
  publication-title: Ecol. Evol.
  doi: 10.1002/ece3.1136
– volume: 3
  start-page: 217
  year: 2012
  ident: 4224_CR22
  publication-title: Methods Ecol. Evol.
  doi: 10.1111/j.2041-210X.2011.00169.x
– ident: 4224_CR6
– volume: 285
  start-page: 20181743
  year: 2018
  ident: 4224_CR11
  publication-title: Proc. R. Soc. B
  doi: 10.1098/rspb.2018.1743
– volume: 53
  start-page: 767
  year: 2019
  ident: 4224_CR30
  publication-title: Mol. Biol.
  doi: 10.1134/S0026893319050030
– volume: 2
  start-page: 1065
  year: 2018
  ident: 4224_CR38
  publication-title: Nat. Ecol. Evol.
  doi: 10.1038/s41559-018-0558-7
– volume: 546
  start-page: 646
  year: 2017
  ident: 4224_CR33
  publication-title: Nature
  doi: 10.1038/nature22975
– volume: 10
  start-page: 2376
  year: 2020
  ident: 4224_CR23
  publication-title: Animals
  doi: 10.3390/ani10122376
– volume: 18
  start-page: 646
  year: 2018
  ident: 4224_CR29
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0045-0
– volume: 25
  start-page: 187
  year: 2011
  ident: 4224_CR4
  publication-title: J. Vet. Intern. Med.
  doi: 10.1111/j.1939-1676.2011.0695.x
– ident: 4224_CR46
– ident: 4224_CR40
– volume: 17
  start-page: e3000494
  year: 2019
  ident: 4224_CR41
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.3000494
– volume: 266
  start-page: 493
  year: 1999
  ident: 4224_CR5
  publication-title: Proc. R. Soc. B
  doi: 10.1098/rspb.1999.0664
– volume: 68
  start-page: 234
  year: 2018
  ident: 4224_CR43
  publication-title: Syst. Biol.
  doi: 10.1093/sysbio/syy060
– volume: 347
  start-page: 12
  year: 2015
  ident: 4224_CR7
  publication-title: Science
  doi: 10.1126/science.347.6217.12
– ident: 4224_CR10
– volume: 27
  start-page: 468
  year: 1996
  ident: 4224_CR25
  publication-title: J. Zoo Wildl. Med.
– volume: 93
  start-page: 1715
  year: 2018
  ident: 4224_CR37
  publication-title: Biol. Rev.
  doi: 10.1111/brv.12415
– volume: 317
  start-page: 236
  year: 2007
  ident: 4224_CR28
  publication-title: Science
  doi: 10.1126/science.1138275
– ident: 4224_CR39
– volume: 20
  start-page: 289
  year: 2004
  ident: 4224_CR44
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btg412
– volume: 26
  start-page: 1569
  year: 2010
  ident: 4224_CR42
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btq228
– volume: 6
  year: 2016
  ident: 4224_CR21
  publication-title: Sci. Rep.
  doi: 10.1038/srep36361
– volume: 30
  start-page: 960
  year: 2017
  ident: 4224_CR16
  publication-title: J. Evol. Biol.
  doi: 10.1111/jeb.13060
– volume: 34
  start-page: 65
  year: 2020
  ident: 4224_CR20
  publication-title: Funct. Ecol.
  doi: 10.1111/1365-2435.13474
– volume: 18
  start-page: 433
  year: 2018
  ident: 4224_CR35
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-018-0004-9
– volume: 314
  start-page: 1850
  year: 2015
  ident: 4224_CR17
  publication-title: JAMA
  doi: 10.1001/jama.2015.13134
– volume: 45
  start-page: 621
  year: 2016
  ident: 4224_CR14
  publication-title: Int. J. Epidemiol.
  doi: 10.1093/ije/dyv199
– volume: 28
  start-page: 7
  year: 2007
  ident: 4224_CR26
  publication-title: Breast Disease
  doi: 10.3233/BD-2007-28102
– volume: 25
  start-page: 151
  year: 2014
  ident: 4224_CR3
  publication-title: Cancer Causes Control
  doi: 10.1007/s10552-013-0317-7
– volume: 26
  start-page: 175
  year: 2011
  ident: 4224_CR12
  publication-title: Trends Ecol. Evol.
  doi: 10.1016/j.tree.2011.01.002
– volume: 58
  start-page: 235
  year: 2017
  ident: 4224_CR8
  publication-title: Environ. Mol. Mutagen.
  doi: 10.1002/em.22087
– ident: 4224_CR47
– ident: 4224_CR24
– reference: 35102282 - Nat Rev Cancer. 2022 Mar;22(3):129
SSID ssj0005174
Score 2.6552134
Snippet Cancer is a ubiquitous disease of metazoans, predicted to disproportionately affect larger, long-lived organisms owing to their greater number of cell...
SourceID pubmedcentral
hal
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 263
SubjectTerms 631/181
631/601
631/67
Age
Aging
Animals
Animals, Zoo - classification
Aquariums
Aùimals, Zoo
Bias
Birth control
Body mass
Body Size
Body Weight
Cancer
Carcinogens
Carnivory
Cell cycle
Cell division
Diet - veterinary
Empirical analysis
Evolution
Health risks
Humanities and Social Sciences
Life expectancy
Life history
Life Sciences
Life span
Longevity
Mammals
Mammals - classification
Mortality
Mortality risk
multidisciplinary
Mutation
Neoplasms
Neoplasms - mortality
Neoplasms - pathology
Neoplasms - veterinary
Paradoxes
Phylogenetics
Phylogeny
Risk
Risk Factors
Science
Science (multidisciplinary)
Species
Species Specificity
SummonAdditionalLinks – databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1RT9wwDLbgEBIv02DAymAq0x5AUNE2Tto8otPQCQFPQ-ItStpUIHFl4o79_tm59k4HY9L62Lqtaye1rXz-AvDd1crVtXaJbCyTaqsqcRhgfzWz02mUBfc7X9-o0S1e3sm7Fcj7XpgA2g-UluE33aPDziYUaEqGy1LxixR2ErkKa0zdzgXXUA0XsI5XzMtdo0wqyr88YykYrd4zFPJtnvkWLvlqzTSEoouP8KHLIePzmdabsOLbLVgPWM5qsgWb3XydxEcdqfTxJ9gbsnufY4aSxzaoE4_teEyjbxtuL378HI6Sbl-EpJIFThOhU9944Sh5khqxbqrcKbQFxSJtvdIZ5pUrdNOkFYUir5DzIqWtlU1tsSnFDgzap9Z_hpgCtvOUctWhRvbalqnwtc9c43OLmEeQ9QYyVUcazntXPJqweC1KMzOqIaOaYFQjIziZ3_NrRpnxT-lvZPe5ILNdj86vDJ9jqtZCYP47i2C_d4vp5tjEBCr9tESJERzOL9Ps4CUP2_qnF5ahalsLOiLYnXlx_iqBlJppUUZQLPl3SZflK-3DfWDgpiJPSqEiOO1HwkKt9z917__Ev8BGzr0WaZZkYh8G0-cXf0AZ0NR9DUP-D-dV-Uk
  priority: 102
  providerName: Springer Nature
Title Cancer risk across mammals
URI https://link.springer.com/article/10.1038/s41586-021-04224-5
https://www.ncbi.nlm.nih.gov/pubmed/34937938
https://www.proquest.com/docview/2620408454
https://www.proquest.com/docview/2613293333
https://hal.science/hal-03527342
https://pubmed.ncbi.nlm.nih.gov/PMC8755536
Volume 601
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3fa9swED6alsFextr9ctcFb-xhYzO1LcmWnkpnmoWxlTFWyJuRLJkOFqet0_79vVOUhLS0fjDYkrF0OunupE-fAD4aWxhrlUlEq4lUu2gSwz3szxI7neKipP3Ov06L8Rn_MRGTMOHWB1jlckz0A7WdNTRHfuiJ01PJBT-6uEzo1ChaXQ1HaAxgJ0NLQ5AuOfq-hnjcYWEOm2ZSJg97NFyS4LcYTHM0Y4nYMEyDc4JF3vc570Mn76yferM0eg7Pgj8ZHy8UYBe2XLcHTzyus-n3YDf03T7-FAimP7-A_Yqa-iomWHmsfXHiqZ5OURNfwtno5G81TsIZCUkjSj5PmEpd65hBR0oozm3b5KbgukS7pLQrVMbzxpSqbdMGzZIrOPlIhdJatFbzVrJXsN3NOvcGYjTexqH7ZX287JSWKXPWZaZ1ueY8jyBbCqhuAoE4nWPxv_YL2UzWC6HWKNTaC7UWEXxZfXOxoM94NPcHlPsqIzFfj49_1vSOaFtLxvObLIKDZbPUob_19Vo7Ini_SsaeQssfunOza8qDkbdieEXwetGKq18xjm6aYjKCcqN9N8qymdL9O_ds3BjwCcGKCL4uNWFdrIeruv94Ld7C05z2WaRZkrED2J5fXbt36P3MzRAG5aTEu6yyoVf3Iex8Ozn9_QefqqK6BXOl_6o
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB61RYheEC2vlAIBgQSCqElsJ_EBoaqwbOm2p1bqzbVjR63EZkuzBfGn-I3MOMmuthW9NcfYSezxeB6Zmc8Ab4zNjLXSRKLSBKqdlZHhPu3PEjqd5CKneuf9g2x4xL8fi-Ml-NvXwlBaZS8TvaC2k5L-kW954PS44IJ_Pv8Z0alRFF3tj9Bo2WLP_fmNLlvzafcLru_bNB18PdwZRt2pAlEpcj6N0Ml3lWMGTQ8hObdVmZqM6xwludQukwlPS5PLqopLFOQu42RVZFJrUVnNq4Lhe5fhDmeoyakyffBtnlJyBfW5K9KJWbHVoKIsKN0XnXeOajMSC4pw-ZTSMK_buNdTNa_Ea70aHDyA-539Gm63DLcGS65eh7s-j7Rs1mGtkxVN-K4DtH7_EDZ2iLUuQkpjD7UfTjjW4zFy_iM4uhXqPYaVelK7pxCisWAcmnvW--dO6iJmzrrEVC7VnKcBJD2BVNkBltO5GT-UD5yzQrVEVUhU5YmqRAAfZs-ct3AdN_Z-jXSfdSSk7eH2SNE9gonNGU9_JQFs9suiuv3dqDk3BvBq1ow7k8ItunaTS-qDnr5keAXwpF3F2acYR7NQsiKAfGF9F8ay2FKfnXr0b3QwhWBZAB97TpgP6_9T3bh5Fi_h3vBwf6RGuwd7z2A1pRqPOIkStgkr04tL9xwtr6l54dk9hJPb3l__AHTTOBg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9QwEB21RaBeEC1fKQUCAgkE0SaxndgHhKotqy0tFQcq9ebaiaNWYrOl2YL4a_w6Zpxky7ait-YYO4k9nhnPxM_PAK9smdmyVDYSlSFS7ayILPewv5LY6RQXOe13_rKfjQ_450NxuAR_-r0wBKvsfaJ31OW0oH_kA0-cHksu-KDqYBFft0cfT39EdIIUrbT2x2m0KrLrfv_C9K35sLONY_06TUefvg3HUXfCQFSInM8iTPhd5ZjFMEQozsuqSG3GTY5eXRmXqYSnhc1VVcUFOnWXcYowMmWMqErDK8nwvctwK2e5JBuTw3_gJZcYoLsNOzGTgwYnTUnQX0zkOU6hkViYFJePCZJ5Nd69Ctu8tHbrp8TRPbjbxbLhVqt8a7Dk6nW47TGlRbMOa53faMI3Hbn12_uwMSQ1OwsJ0h4a35xwYiYTtIIHcHAj0nsIK_W0do8hxMDBOgz9Sp-rO2VkzFzpElu51HCeBpD0AtJFR15OZ2h8134RnUndClWjULUXqhYBvJs_c9pSd1xb-yXKfV6RWLfHW3ua7hFlbM54-jMJYLMfFt3ZeqMvNDOAF_NitFJaejG1m55THcz6FcMrgEftKM4_xTiGiIrJAPKF8V1oy2JJfXLsmcAx2RSCZQG87zXholn_7-rG9b14DnfQsvTezv7uE1hNabtHnEQJ24SV2dm5e4pB2Mw-89oewtFNm9df8lE8GQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cancer+risk+across+mammals&rft.jtitle=Nature+%28London%29&rft.au=Vincze%2C+Orsolya&rft.au=Colchero%2C+Fernando&rft.au=Lema%C3%AEtre%2C+Jean-Francois&rft.au=Conde%2C+Dalia+A.&rft.date=2022-01-13&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=601&rft.issue=7892&rft.spage=263&rft.epage=267&rft_id=info:doi/10.1038%2Fs41586-021-04224-5&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41586_021_04224_5
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon