Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond

• Published in: British journal of cancer Vol. 124; no. 2; pp. 345 - 358
• Main Authors: Keller, Laura, Belloum, Yassine, Wikman, Harriet, Pantel, Klaus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2021; Nature Publishing Group; Cancer Research UK
• Subjects: 692/308/53; 692/4017; 692/4028; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Biomedical and Life Sciences; Biomedicine; Biopsy; Cancer; Cancer Research; Circulating Tumor DNA - blood; Deoxyribonucleic acid; DNA; DNA methylation; DNA Mutational Analysis; Drug Resistance; Epidemiology; Humans; Life Sciences; Liquid Biopsy; Molecular Medicine; Mutation; Neoplasms - blood; Neoplasms - genetics; Oncology; Review; Review Article; Tumors

Cell-free DNA (cfDNA) derived from tumours is present in the plasma of cancer patients. The majority of currently available studies on the use of this circulating tumour DNA (ctDNA) deal with the detection of mutations. The analysis of cfDNA is often discussed in the context of the noninvasive detec...