CD84 is a survival receptor for CLL cells

• Published in: Oncogene Vol. 33; no. 8; pp. 1006 - 1016
• Main Authors: Binsky-Ehrenreich, I, Marom, A, Sobotta, M C, Shvidel, L, Berrebi, A, Hazan-Halevy, I, Kay, S, Aloshin, A, Sagi, I, Goldenberg, D M, Leng, L, Bucala, R, Herishanu, Y, Haran, M, Shachar, I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.02.2014; Nature Publishing Group
• Subjects: 631/80/86; 692/420/755; 692/699/67/1990/283/1895; Analysis; Antigens, CD - physiology; Antigens, Differentiation, B-Lymphocyte - immunology; Apoptosis; Base Sequence; Bcl-2 protein; Bone marrow; Case-Control Studies; CD5 antigen; Cell activation; Cell Biology; Cell death; Cell Line, Tumor; Cell surface; Cell Survival; Chronic lymphocytic leukemia; DNA Primers; Gene therapy; Genetic aspects; Health aspects; Histocompatibility Antigens Class II - immunology; Human Genetics; Humans; Internal Medicine; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Leukocyte migration; Lymphatic leukemia; Lymphocyte receptors; Lymphocytes B; Macrophage migration inhibitory factor; Mcl-1 protein; Medicine; Medicine & Public Health; mRNA; Oncology; original-article; Peripheral blood; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Signaling Lymphocytic Activation Molecule Family; Survival analysis; T cells; Israel; CD74; apoptosis; CD84; MIF; survival

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5+ B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating m...