Lycoperoside H, a Tomato Seed Saponin, Improves Epidermal Dehydration by Increasing Ceramide in the Stratum Corneum and Steroidal Anti-Inflammatory Effect

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 19; p. 5860
• Main Authors: Takeda, Shogo, Miyasaka, Kenchi, Shrestha, Sarita, Manse, Yoshiaki, Morikawa, Toshio, Shimoda, Hiroshi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.09.2021; MDPI
• Subjects: anti-inflammation; ceramide; Dermatitis; Enzymes; Flavonoids; Histamine; Hydration; lycoperoside; Muscle contraction; Oral administration; Permeability; Proteins; Seeds; steroidal saponin; tomato seed; transepidermal water loss; Wound healing

Tomatoes are widely consumed, however, studies on tomato seeds are limited. In this study, we isolated 11 compounds including saponins and flavonol glycosides from tomato seeds and evaluated their effects on epidermal hydration. Among the isolated compounds, tomato seed saponins (10 µM) significantl...