Maternal high-fat diet impacts endothelial function in nonhuman primate offspring

• Published in: International Journal of Obesity Vol. 37; no. 2; pp. 254 - 262
• Main Authors: Fan, L, Lindsley, S R, Comstock, S M, Takahashi, D L, Evans, A E, He, G-W, Thornburg, K L, Grove, K L
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2013; Nature Publishing Group
• Subjects: 631/443/319/1642/393; 631/443/592/75; 692/700/565/2072; Abdomen; Animals; Animals, Newborn; Biological and medical sciences; Blood; Calories; Cardiovascular diseases; Cardiovascular system; Carotid Intima-Media Thickness; Complications and side effects; Coronary vessels; Demographic aspects; Diabetes; Diet; Diet, High-Fat - adverse effects; Disease; Disease Models, Animal; Endothelium; Endothelium, Vascular - pathology; Epidemiology; Fasting - blood; Female; Fetal Growth Retardation - metabolism; Fetal Growth Retardation - physiopathology; Gene Expression Regulation, Developmental; General aspects; Health aspects; Health Promotion and Disease Prevention; Insulin resistance; Internal Medicine; Ketogenic diet; Liver - metabolism; Macaca; Male; Malnutrition; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Medical sciences; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolic disorders; Neurosciences; Nutrition; Nutrition research; Obesity; Obesity - blood; Obesity - complications; Obesity - pathology; Obesity in children; Offspring; Original; original-article; Overnutrition; Overnutrition - blood; Overnutrition - complications; Placental Insufficiency - pathology; Pregnancy; Prenatal Exposure Delayed Effects - blood; Prenatal Exposure Delayed Effects - pathology; Primates; Prognosis; Public Health; Real-Time Polymerase Chain Reaction; Research centers; Risk factors; Weaning; United States; Oregon; United States > US; endothelium; intrauterine; juvenile offspring; programming; over-nutrition; Human; Obesity; Nutrition; Nutrition disorder; Programming; Metabolic diseases; In utero; Feeding; Endothelium; Progeny; Vertebrata; Mammalia; Mother; Diet; Uterus; Female genital system; Fat; Primates; Child; Nutritional status

OBJECTIVE: The link between maternal under-nutrition and cardiovascular disease (CVD) in the offspring later in life is well recognized, but the impact of maternal over-nutrition on the offspring's cardiovascular function and subsequent risk for CVD later in life remains unclear. Here, we inves...