Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

• Published in: Nature communications Vol. 12; no. 1; pp. 7009 - 22
• Main Authors: Pennemann, Friederike L., Mussabekova, Assel, Urban, Christian, Stukalov, Alexey, Andersen, Line Lykke, Grass, Vincent, Lavacca, Teresa Maria, Holze, Cathleen, Oubraham, Lila, Benamrouche, Yasmine, Girardi, Enrico, Boulos, Rasha E., Hartmann, Rune, Superti-Furga, Giulio, Habjan, Matthias, Imler, Jean-Luc, Meignin, Carine, Pichlmair, Andreas
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/109; 13/21; 13/44; 13/89; 14/19; 14/63; 38/35; 38/39; 38/77; 631/250/127/1212; 631/250/262/2106; 631/326/596; 82/16; 82/58; 82/80; 82/83; Animals; Antiviral Agents; Antiviral drugs; Binders; Binding; Depletion; Double-stranded RNA; Drosophila melanogaster; Evolution, Molecular; Flies; Humanities and Social Sciences; Humans; Immunity, Innate; Immunology; Innate immunity; Interferon; Kinases; Life Sciences; Mammalian cells; Mammals; Mice; multidisciplinary; Nucleic acids; Nucleic Acids - chemistry; Nucleic Acids - immunology; Protein Serine-Threonine Kinases; Proteins; Proteomics; RNA Interference; RNA, Double-Stranded; Science; Science (multidisciplinary); Species; Species Specificity; THP-1 Cells; Viral Proteins - chemistry; Viral Proteins - immunology; Viruses

The cell intrinsic antiviral response of multicellular organisms developed over millions of years and critically relies on the ability to sense and eliminate viral nucleic acids. Here we use an affinity proteomics approach in evolutionary distant species (human, mouse and fly) to identify proteins t...