Early-Life Insults Impair Parvalbumin Interneurons via Oxidative Stress: Reversal by N-Acetylcysteine

• Published in: Biological psychiatry (1969) Vol. 73; no. 6; pp. 574 - 582
• Main Authors: Cabungcal, Jan-Harry, Steullet, Pascal, Kraftsik, Rudolf, Cuenod, Michel, Do, Kim Q.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.03.2013; Elsevier
• Subjects: Acetylcysteine - pharmacology; Adult and adolescent clinical studies; Age Factors; Animals; Anterior cingulate cortex; Antioxidants - pharmacology; Biological and medical sciences; Cell Proliferation - drug effects; gene-environment interactions; glutamate cysteine ligase; Glutamate-Cysteine Ligase - genetics; glutathione; Glutathione - biosynthesis; Gyrus Cinguli - drug effects; Gyrus Cinguli - growth & development; Gyrus Cinguli - metabolism; Interneurons - drug effects; Interneurons - metabolism; Male; Medical sciences; Mice; Mice, Knockout; Oxidative Stress - drug effects; Oxidative Stress - genetics; Oxidative Stress - physiology; parvalbumin; Parvalbumins - metabolism; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; schizophrenia; Anterior cingulate cortex; gene-environment interactions; glutathione; parvalbumin; glutamate cysteine ligase; Oxidative stress; Calcium; Central nervous system; Acetylcysteine; Schizophrenia; Environmental factor; Inorganic element; Encephalon; Interneuron; Psychosis; Binding protein; Cingulate cortex; Ligases; Glutathione; Glutamate-cysteine ligase; Thiol; Carbon-nitrogen ligases; Enzyme; Parvalbumin; Mucolytic; Genotype environment interaction; Early

A hallmark of the pathophysiology of schizophrenia is a dysfunction of parvalbumin-expressing fast-spiking interneurons, which are essential for the coordination of neuronal synchrony during sensory and cognitive processing. Oxidative stress as observed in schizophrenia affects parvalbumin interneur...