Reduced Dopamine Response to Amphetamine in Subjects at Ultra-High Risk for Addiction

• Published in: Biological psychiatry (1969) Vol. 76; no. 1; pp. 23 - 30
• Main Authors: Casey, Kevin F., Benkelfat, Chawki, Cherkasova, Mariya V., Baker, Glen B., Dagher, Alain, Leyton, Marco
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2014; Elsevier
• Subjects: [11C]raclopride; Addictive behaviors; Adult and adolescent clinical studies; Amphetamine - pharmacology; Biological and medical sciences; Case-Control Studies; Central Nervous System Stimulants - pharmacology; Corpus Striatum - diagnostic imaging; Corpus Striatum - metabolism; Dopamine; Dopamine - metabolism; Dopamine Antagonists; Drug addiction; Family Health; Female; Functional Neuroimaging; Humans; Male; Medical sciences; PET; Positron-Emission Tomography; Prodromal Symptoms; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Raclopride; stimulants; substance dependence; Substance-Related Disorders - diagnosis; Substance-Related Disorders - diagnostic imaging; vulnerability; Young Adult; stimulants; Dopamine; vulnerability; [11C]raclopride; PET; substance dependence; [ 11C]raclopride; Amphetamine derivatives; Radionuclide study; High risk; Psychotropic; Central nervous system; Encephalon; Amfetamine; Drug of abuse; [; C]raclopride; Human; Drug addiction; Raclopride; CNS stimulant; Dopamine antagonist; Substance abuse; Vulnerability; Catecholamine; Biological fixation; D2 Dopamine receptor; Addiction; Young adult; Neurotransmitter; Positron emission tomography; Emission tomography; [C]raclopride

Not everyone who tries addictive drugs develops a substance use disorder. One of the best predictors of risk is a family history (FH) of substance use problems. In part, this might reflect perturbed mesolimbic dopamine responses. We measured amphetamine-induced changes in [11C]raclopride binding in...