Structural design of tetravalent T-cell engaging bispecific antibodies: improve developability by engineering disulfide bonds - Yu, Lin; Huang, Nan; Ge, Liangpeng; Sun, Heng; Fu, Yuna; Liu, Chundong; Wang, Jianhua (Journal of biological engineering, 2021)
Keywords: Antibodies; Antigen (tumor-associated); Antigens; Binding; Biological properties; Biosensors; Bispecific antibodies; Bispecific antibody; Cancer; CD3 antigen; Chemical bonds; Cysteine; Cystine; Cytotoxicity; Data analysis; Design; Disulfide bond; Disulfide bonds; Domains; Fab; Immunoglobulin G; Immunotherapy; Laboratories; Light; Lymphocytes; Lymphocytes T; Protein engineering; Proteins; ScFv; Scientific equipment and supplies industry; Software; Stability; Structural design; Structural engineering; T cells; Thermal stability; Toxicity; Tumor antigens; Tumor cells; Tumors; Canada; United States; China; United States--US