Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing

• Published in: Discover nano Vol. 18; no. 1; p. 154
• Main Authors: Sharda, Deepinder, Ghosh, Sandip, Kaur, Pawandeep, Basu, Biswarup, Choudhury, Diptiman
• Format: Journal Article
• Language: English
• Published: New York Springer US 12.12.2023; Springer Nature B.V; Springer
• Subjects: Burn wound healing; Chemistry and Materials Science; Chitosan; collagen; Cytokines; Diabetes mellitus; GA-binding protein; Inflammation; Inflammatory cytokines; Insulin; interleukin-10; interleukin-6; Materials Science; metabolic diseases; mice; Modulators; Molecular Medicine; Nanochemistry; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; Neuromodulation; Nrf-2 pathway; Oxidative stress; Regeneration; Regeneration (physiology); therapeutics; Tissue engineering; tissue repair; Wound healing; Inflammatory cytokines; Chitosan; Insulin; Nrf-2 pathway; Burn wound healing

Burn injuries are characterized by prolonged inflammatory phases, neurovascular damage, and hypermetabolism, eventually causing improper tissue regeneration. Insulin has gained considerable attention in normal and diabetic wound healing, yet its role in burn wounds remains poorly understood. In this...