The mechanism of HMGB1 secretion and release

• Published in: Experimental & molecular medicine Vol. 54; no. 2; pp. 91 - 102
• Main Authors: Chen, Ruochan, Kang, Rui, Tang, Daolin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2022; Springer Nature B.V; 생화학분자생물학회
• Subjects: 631/337; 692/308; Acetylation; ADP-ribosylation; Apoptosis; Autophagy; Biomedical and Life Sciences; Biomedicine; Cell activation; Cell death; Cell interactions; Cellular stress response; Chromosomes; Cytoplasm; Drug development; Ferroptosis; High mobility group proteins; HMGB1 protein; Immune response; Immunosuppressive agents; Inflammation; Inflammatory diseases; Medical Biochemistry; Molecular Medicine; Necroptosis; Phosphorylation; Proteins; Pyroptosis; Review; Review Article; Ribosylation; Stem Cells; Structure-function relationships; Therapeutic targets; 생화학

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone that maintains the structure and function of chromosomes. In the cytoplasm, HMGB1 can promote autophagy by binding to BECN1 pr...