Neurochemical Heterogeneity of Rats Predicted by Different Measures to be High Ethanol Consumers

• Published in: Alcoholism, clinical and experimental research Vol. 37; no. s1; pp. E141 - E151
• Main Authors: Barson, Jessica R., Fagan, Shawn E., Chang, Guo-Qing, Leibowitz, Sarah F.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2013
• Subjects: Alcohol Drinking - genetics; Alcohol Drinking - metabolism; Alcohol Drinking - physiopathology; Alcoholic beverages; Animals; Brain Chemistry - drug effects; Brain Chemistry - genetics; Enkephalins - biosynthesis; Ethanol - administration & dosage; Forecasting; Galanin; Galanin - biosynthesis; Hypothalamus; Intracellular Signaling Peptides and Proteins - biosynthesis; Intracellular Signaling Peptides and Proteins - genetics; Male; Motor Activity - drug effects; Motor Activity - genetics; Naltrexone; Neuropeptides - biosynthesis; Neuropeptides - genetics; Novelty-Seeking; Orexins; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Triglycerides; Triglycerides - metabolism

Background Alcoholism is a heterogeneous disease, with subjects possibly differing both in the best measure that predicts their excess consumption and in their most effective pharmacotherapy. Two different measures, high novelty‐induced activity and high‐fat‐induced triglycerides (TGs), are known to...