Amino Acid Polymorphisms in Hla Class II Differentiate Between Thyroid and Polyglandular Autoimmunity

• Published in: The journal of clinical endocrinology and metabolism Vol. 105; no. 6; pp. 1737 - 1747
• Main Authors: Frommer, Lara, Flesch, Brigitte K, König, Jochem, Kahaly, George J
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.06.2020; Copyright Oxford University Press
• Subjects: Alleles; Amino acids; Amino Acids - genetics; Autoimmunity; Biomarkers - analysis; Case-Control Studies; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diagnosis, Differential; Disease; DQA1 protein; Drb1 protein; Endocrine disorders; Female; Follow-Up Studies; Genetic aspects; Genetic polymorphisms; Genetic Predisposition to Disease; Health aspects; Histocompatibility antigen HLA; Histocompatibility antigens; Histocompatibility Antigens Class II - genetics; HLA histocompatibility antigens; Humans; Immunogenetics; Male; Peptides; Polyendocrinopathies, Autoimmune - diagnosis; Polyendocrinopathies, Autoimmune - genetics; Polyendocrinopathies, Autoimmune - immunology; Polymorphism, Genetic; Prognosis; Protein binding; Statistical analysis; Thyroid diseases; Thyroid gland; Thyroiditis, Autoimmune - diagnosis; Thyroiditis, Autoimmune - genetics; Thyroiditis, Autoimmune - immunology; Germany; codon; polyglandular autoimmunity; HLA class II; immunogenetics; autoimmune polyendocrinopathy; amino acid polymorphisms

Abstract Context The structure of the human leucocyte antigen (HLA) peptide-binding clefts strongly contributes to monoglandular and polyglandular autoimmunity (AP). Objective To investigate the impact of amino acid polymorphisms on the peptide-binding interactions within HLA class II and its associ...