Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

• Published in: Molecular systems biology Vol. 11; no. 12; pp. 852 - n/a
• Main Authors: Fraser, James, Ferrai, Carmelo, Chiariello, Andrea M, Schueler, Markus, Rito, Tiago, Laudanno, Giovanni, Barbieri, Mariano, Moore, Benjamin L, Kraemer, Dorothee CA, Aitken, Stuart, Xie, Sheila Q, Morris, Kelly J, Itoh, Masayoshi, Kawaji, Hideya, Jaeger, Ines, Hayashizaki, Yoshihide, Carninci, Piero, Forrest, Alistair RR, Semple, Colin A, Dostie, Josée, Pombo, Ana, Nicodemi, Mario
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2015; EMBO Press; John Wiley and Sons Inc; Springer Nature
• Subjects: Animals; Cell Differentiation; Cell division; Cells, Cultured; Chromatin; Chromatin - chemistry; Chromatin Assembly and Disassembly; chromatin contacts; chromosome architecture; Chromosomes; Chromosomes - chemistry; Datasets; Deoxyribonucleic acid; Differentiation (biology); DNA; Domains; EMBO09; EMBO11; EMBO17; Epigenesis, Genetic; epigenetics; Folding; Gene expression; Gene Expression Regulation; Genomes; Innovations; Mammals; Mice; Mouse Embryonic Stem Cells - cytology; Neurons; Neurons - cytology; Packaging; polymer modelling; Stem cells; Structural hierarchy; Substructures; Transcription; Transcription, Genetic; Trees; United Kingdom > UK; Japan; polymer modelling; chromosome architecture; chromatin contacts; epigenetics; gene expression

Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA. TADs have internal substructures that are often cell type specific, but their higher‐order organization remains elusive....