The Spectrum of Epidemiology Underlying Sudden Cardiac Death
Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who experience a sudden cardiac arrest will not surv...
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Published in | Circulation research Vol. 116; no. 12; pp. 1887 - 1906 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
American Heart Association, Inc
05.06.2015
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Subjects | |
Online Access | Get full text |
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Abstract | Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who experience a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also rarely occurs in the young, where it is more commonly because of inherited disorders. Coronary heart disease is known to be the most common pathology underlying SCD, followed by cardiomyopathies, inherited arrhythmia syndromes, and valvular heart disease. During the past 3 decades, declines in SCD rates have not been as steep as for other causes of coronary heart disease deaths, and there is a growing fraction of SCDs not due to coronary heart disease and ventricular arrhythmias, particularly among certain subsets of the population. The growing heterogeneity of the pathologies and mechanisms underlying SCD present major challenges for SCD prevention, which are magnified further by a frequent lack of recognition of the underlying cardiac condition before death. Multifaceted preventative approaches, which address risk factors in seemingly low-risk and known high-risk populations, will be required to decrease the burden of SCD. In this Compendium, we review the wide-ranging spectrum of epidemiology underlying SCD within both the general population and in high-risk subsets with established cardiac disease placing an emphasis on recent global trends, remaining uncertainties, and potential targeted preventive strategies. |
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AbstractList | Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who experience a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also rarely occurs in the young, where it is more commonly because of inherited disorders. Coronary heart disease is known to be the most common pathology underlying SCD, followed by cardiomyopathies, inherited arrhythmia syndromes, and valvular heart disease. During the past 3 decades, declines in SCD rates have not been as steep as for other causes of coronary heart disease deaths, and there is a growing fraction of SCDs not due to coronary heart disease and ventricular arrhythmias, particularly among certain subsets of the population. The growing heterogeneity of the pathologies and mechanisms underlying SCD present major challenges for SCD prevention, which are magnified further by a frequent lack of recognition of the underlying cardiac condition before death. Multifaceted preventative approaches, which address risk factors in seemingly low-risk and known high-risk populations, will be required to decrease the burden of SCD. In this Compendium, we review the wide-ranging spectrum of epidemiology underlying SCD within both the general population and in high-risk subsets with established cardiac disease placing an emphasis on recent global trends, remaining uncertainties, and potential targeted preventive strategies. Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15–20% of all deaths. Although resuscitation rates are generally improving throughout the world, the majority of individuals who suffer a sudden cardiac arrest will not survive. SCD most often develops in older adults with acquired structural heart disease, but it also rarely occurs in the young, where it is more commonly due to inherited disorders. Coronary heart disease (CHD) is known to be the most common pathology underlying SCD, followed by cardiomyopathies, inherited arrhythmia syndromes, and valvular heart disease. Over the past three decades, declines in SCD rates have not been as steep as for other causes of CHD deaths, and there is a growing fraction of SCDs not due to CHD and/or ventricular arrhythmias, particularly among certain subsets of the population. The growing heterogeneity of the pathologies and mechanisms underlying SCD present major challenges for SCD prevention, which are magnified further by a frequent lack of recognition of the underlying cardiac condition prior to death. Multifaceted preventative approaches, which address risk factors in seemingly low risk and known high-risk populations will be required to decrease the burden of SCD. In this Compendium, we review the wide-ranging spectrum of epidemiology underlying SCD within both the general population and in high-risk subsets with established cardiac disease placing an emphasis on recent global trends, remaining uncertainties, and potential targeted preventive strategies. |
Author | Shimizu, Wataru Hayashi, Meiso Albert, Christine M |
AuthorAffiliation | From the Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (M.H., W.S.); and Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (C.M.A.) |
AuthorAffiliation_xml | – name: From the Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (M.H., W.S.); and Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (C.M.A.) – name: 1 Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan – name: 2 Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Massachusetts, USA |
Author_xml | – sequence: 1 givenname: Meiso surname: Hayashi fullname: Hayashi, Meiso organization: From the Department of Cardiovascular Medicine, Nippon Medical School, Tokyo, Japan (M.H., W.S.); and Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (C.M.A.) – sequence: 2 givenname: Wataru surname: Shimizu fullname: Shimizu, Wataru – sequence: 3 givenname: Christine surname: Albert middlename: M fullname: Albert, Christine M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26044246$$D View this record in MEDLINE/PubMed |
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PublicationDate | 2015-June-5 2015-Jun-05 2015-06-05 20150605 |
PublicationDateYYYYMMDD | 2015-06-05 |
PublicationDate_xml | – month: 06 year: 2015 text: 2015-June-5 day: 05 |
PublicationDecade | 2010 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | Circulation research |
PublicationTitleAlternate | Circ Res |
PublicationYear | 2015 |
Publisher | American Heart Association, Inc |
Publisher_xml | – name: American Heart Association, Inc |
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Snippet | Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%–20% of all deaths. Although... Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15%-20% of all deaths. Although... Sudden cardiac death (SCD) from cardiac arrest is a major international public health problem accounting for an estimated 15–20% of all deaths. Although... |
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SubjectTerms | Age Distribution Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - physiopathology Comorbidity Death, Sudden, Cardiac - epidemiology Death, Sudden, Cardiac - etiology Environment Ethnic Groups - statistics & numerical data Female Habits Heart Conduction System - physiopathology Heart Diseases - complications Heart Diseases - epidemiology Heart Diseases - genetics Heart Diseases - physiopathology Humans Incidence Male Psychology Risk Factors Sex Distribution |
Title | The Spectrum of Epidemiology Underlying Sudden Cardiac Death |
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