Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways
RATIONALE:Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive. OBJECTIVE:To investigate the molecular mechanisms by...
Saved in:
Published in | Circulation research Vol. 108; no. 6; pp. 716 - 726 |
---|---|
Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
American Heart Association, Inc
18.03.2011
Lippincott Williams & Wilkins |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | RATIONALE:Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive.
OBJECTIVE:To investigate the molecular mechanisms by which PM2.5 mediates inflammatory responses in a mouse model of chronic exposure.
METHODS AND RESULTS:Here, we show that chronic exposure to ambient PM2.5 promotes Ly6C inflammatory monocyte egress from bone-marrow and mediates their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase. Toll-like receptor (TLR)4 and Nox2 (gp91) deficiency prevented monocyte NADPH oxidase activation in response to PM2.5 and was associated with restoration of systemic vascular dysfunction. TLR4 activation appeared to be a prerequisite for NAPDH oxidase activation as evidenced by reduced p47 phosphorylation in TLR4 deficient animals. PM2.5 exposure markedly increased oxidized phospholipid derivatives of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fluid. Correspondingly, exposure of bone marrow–derived macrophages to oxPAPC but not PAPC recapitulated effects of chronic PM2.5 exposure, whereas TLR4 deficiency attenuated this response.
CONCLUSIONS:Taken together, our findings suggest that PM2.5 triggers an increase in oxidized phospholipids in lungs that then mediates a systemic cellular inflammatory response through TLR4/NADPH oxidase–dependent mechanisms. |
---|---|
AbstractList | Chronic exposure to ambient air-borne particulate matter of < 2.5 μm (PM₂.₅) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive.
To investigate the molecular mechanisms by which PM₂.₅ mediates inflammatory responses in a mouse model of chronic exposure.
Here, we show that chronic exposure to ambient PM₂.₅ promotes Ly6C(high) inflammatory monocyte egress from bone-marrow and mediates their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase. Toll-like receptor (TLR)4 and Nox2 (gp91(phox)) deficiency prevented monocyte NADPH oxidase activation in response to PM₂.₅ and was associated with restoration of systemic vascular dysfunction. TLR4 activation appeared to be a prerequisite for NAPDH oxidase activation as evidenced by reduced p47(phox) phosphorylation in TLR4 deficient animals. PM₂.₅ exposure markedly increased oxidized phospholipid derivatives of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fluid. Correspondingly, exposure of bone marrow-derived macrophages to oxPAPC but not PAPC recapitulated effects of chronic PM₂.₅ exposure, whereas TLR4 deficiency attenuated this response.
Taken together, our findings suggest that PM₂.₅ triggers an increase in oxidized phospholipids in lungs that then mediates a systemic cellular inflammatory response through TLR4/NADPH oxidase-dependent mechanisms. RATIONALE:Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive. OBJECTIVE:To investigate the molecular mechanisms by which PM2.5 mediates inflammatory responses in a mouse model of chronic exposure. METHODS AND RESULTS:Here, we show that chronic exposure to ambient PM2.5 promotes Ly6C inflammatory monocyte egress from bone-marrow and mediates their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase. Toll-like receptor (TLR)4 and Nox2 (gp91) deficiency prevented monocyte NADPH oxidase activation in response to PM2.5 and was associated with restoration of systemic vascular dysfunction. TLR4 activation appeared to be a prerequisite for NAPDH oxidase activation as evidenced by reduced p47 phosphorylation in TLR4 deficient animals. PM2.5 exposure markedly increased oxidized phospholipid derivatives of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fluid. Correspondingly, exposure of bone marrow–derived macrophages to oxPAPC but not PAPC recapitulated effects of chronic PM2.5 exposure, whereas TLR4 deficiency attenuated this response. CONCLUSIONS:Taken together, our findings suggest that PM2.5 triggers an increase in oxidized phospholipids in lungs that then mediates a systemic cellular inflammatory response through TLR4/NADPH oxidase–dependent mechanisms. Rationale: Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM 2.5 ) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive. Objective: To investigate the molecular mechanisms by which PM 2.5 mediates inflammatory responses in a mouse model of chronic exposure. Methods and Results: Here, we show that chronic exposure to ambient PM 2.5 promotes Ly6C high inflammatory monocyte egress from bone-marrow and mediates their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase. Toll-like receptor (TLR)4 and Nox2 (gp91 phox ) deficiency prevented monocyte NADPH oxidase activation in response to PM 2.5 and was associated with restoration of systemic vascular dysfunction. TLR4 activation appeared to be a prerequisite for NAPDH oxidase activation as evidenced by reduced p47 phox phosphorylation in TLR4 deficient animals. PM 2.5 exposure markedly increased oxidized phospholipid derivatives of 1-palmitoyl-2-arachidonyl- sn -glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fluid. Correspondingly, exposure of bone marrow–derived macrophages to oxPAPC but not PAPC recapitulated effects of chronic PM 2.5 exposure, whereas TLR4 deficiency attenuated this response. Conclusions: Taken together, our findings suggest that PM 2.5 triggers an increase in oxidized phospholipids in lungs that then mediates a systemic cellular inflammatory response through TLR4/NADPH oxidase–dependent mechanisms. RATIONALE:: Chronic exposure to ambient air-borne particulate matter of <2.5 mu m (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient particles are sensed and how these effects are systemically transduced remain elusive. OBJECTIVE:: To investigate the molecular mechanisms by which PM2.5 mediates inflammatory responses in a mouse model of chronic exposure. METHODS AND RESULTS:: Here, we show that chronic exposure to ambient PM2.5 promotes Ly6Chigh inflammatory monocyte egress from bone-marrow and mediates their entry into tissue niches where they generate reactive oxygen species via NADPH oxidase. Toll-like receptor (TLR)4 and Nox2 (gp91phox) deficiency prevented monocyte NADPH oxidase activation in response to PM2.5 and was associated with restoration of systemic vascular dysfunction. TLR4 activation appeared to be a prerequisite for NAPDH oxidase activation as evidenced by reduced p47phox phosphorylation in TLR4 deficient animals. PM2.5 exposure markedly increased oxidized phospholipid derivatives of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (oxPAPC) in bronchioalveolar lavage fluid. Correspondingly, exposure of bone marrow-derived macrophages to oxPAPC but not PAPC recapitulated effects of chronic PM2.5 exposure, whereas TLR4 deficiency attenuated this response. CONCLUSIONS:: Taken together, our findings suggest that PM2.5 triggers an increase in oxidized phospholipids in lungs that then mediates a systemic cellular inflammatory response through TLR4/NADPH oxidase-dependent mechanisms. |
Author | Kampfrath, Thomas Shah, Zubair Ying, Zhekang Parthasarathy, Sampath Deiuliis, Jeffrey A Xu, Xiaohua Brook, Robert D Padture, Nitin P Rajagopalan, Sanjay Kherada, Nisharahmed Chen, Lung Chi Sun, Qinghua Morawietz, Henning Maiseyeu, Andrei Moffatt-Bruce, Susan Reddy, Kongara M |
AuthorAffiliation | From the Davis Heart & Lung Research Institute (T.K., A.M., Z.Y., Z.S., J.A.D., N.K., S.P., S.M.-B., Q.S., S.R.), Ohio State University College of Medicine, Columbus; Division of Environmental Health Sciences (X.X., Q.S.), Ohio State University College of Public Health, Columbus; Division of Cardiovascular Medicine (R.D.B.), University of Michigan, Ann Arbor; Department of Materials Science and Engineering (K.M.R., N.P.P.), Ohio State University, Columbus; Department of Environmental Medicine and Nelson Institute of Environmental Medicine (L.C.C.), New York University School of Medicine, Tuxedo; and Department of Vascular Endothelium and Microcirculation (H.M.), University of Technology, Dresden, Germany |
AuthorAffiliation_xml | – name: From the Davis Heart & Lung Research Institute (T.K., A.M., Z.Y., Z.S., J.A.D., N.K., S.P., S.M.-B., Q.S., S.R.), Ohio State University College of Medicine, Columbus; Division of Environmental Health Sciences (X.X., Q.S.), Ohio State University College of Public Health, Columbus; Division of Cardiovascular Medicine (R.D.B.), University of Michigan, Ann Arbor; Department of Materials Science and Engineering (K.M.R., N.P.P.), Ohio State University, Columbus; Department of Environmental Medicine and Nelson Institute of Environmental Medicine (L.C.C.), New York University School of Medicine, Tuxedo; and Department of Vascular Endothelium and Microcirculation (H.M.), University of Technology, Dresden, Germany – name: 4 Department of Materials Science and Engineering, The Ohio State University, Columbus, OH, USA – name: 6 Department of Vascular Endothelium and Microcirculation, University of Technology, Dresden, Germany – name: 1 Davis Heart & Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA – name: 2 Division of Environmental Health Sciences, The Ohio State University College of Public Health, Columbus, OH, USA – name: 3 Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA – name: 5 Department of Environmental Medicine and Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA |
Author_xml | – sequence: 1 givenname: Thomas surname: Kampfrath fullname: Kampfrath, Thomas organization: From the Davis Heart & Lung Research Institute (T.K., A.M., Z.Y., Z.S., J.A.D., N.K., S.P., S.M.-B., Q.S., S.R.), Ohio State University College of Medicine, Columbus; Division of Environmental Health Sciences (X.X., Q.S.), Ohio State University College of Public Health, Columbus; Division of Cardiovascular Medicine (R.D.B.), University of Michigan, Ann Arbor; Department of Materials Science and Engineering (K.M.R., N.P.P.), Ohio State University, Columbus; Department of Environmental Medicine and Nelson Institute of Environmental Medicine (L.C.C.), New York University School of Medicine, Tuxedo; and Department of Vascular Endothelium and Microcirculation (H.M.), University of Technology, Dresden, Germany – sequence: 2 givenname: Andrei surname: Maiseyeu fullname: Maiseyeu, Andrei – sequence: 3 givenname: Zhekang surname: Ying fullname: Ying, Zhekang – sequence: 4 givenname: Zubair surname: Shah fullname: Shah, Zubair – sequence: 5 givenname: Jeffrey surname: Deiuliis middlename: A fullname: Deiuliis, Jeffrey A – sequence: 6 givenname: Xiaohua surname: Xu fullname: Xu, Xiaohua – sequence: 7 givenname: Nisharahmed surname: Kherada fullname: Kherada, Nisharahmed – sequence: 8 givenname: Robert surname: Brook middlename: D fullname: Brook, Robert D – sequence: 9 givenname: Kongara surname: Reddy middlename: M fullname: Reddy, Kongara M – sequence: 10 givenname: Nitin surname: Padture middlename: P fullname: Padture, Nitin P – sequence: 11 givenname: Sampath surname: Parthasarathy fullname: Parthasarathy, Sampath – sequence: 12 givenname: Lung surname: Chen middlename: Chi fullname: Chen, Lung Chi – sequence: 13 givenname: Susan surname: Moffatt-Bruce fullname: Moffatt-Bruce, Susan – sequence: 14 givenname: Qinghua surname: Sun fullname: Sun, Qinghua – sequence: 15 givenname: Henning surname: Morawietz fullname: Morawietz, Henning – sequence: 16 givenname: Sanjay surname: Rajagopalan fullname: Rajagopalan, Sanjay |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24021314$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21273555$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkc1uEzEUhS1URNPAI4C8QaymtWfscWaDFE1TEinQKo3YWo59hxgmdrBnmubtcZS0hRUr68rfOffnXKAz5x0g9J6SS0pLelXPFvVicj-ejlNNLvNC8JK8QgPKc5YxLugZGhBCqkwUBTlHFzH-JISyIq_eoPOc5qLgnA9QqNfBO6vxjXWA71TorO5b1QH-qroOAp48bn3sA-CZM72GiO_3sYNNUnxX8YAGfL2PTe90Z73DD1bhb-Pruym-fbRGRcDKGbycL1gy79Y7tY9v0etGtRHend4hWt5MlvU0m99-mdXjeaa5YCTjI2Y0LUUlSsVYwyiBvBFpA0Oh1AyAMM5gZRqhC0OMgAoM06uRUFUOzagYos9H222_2oDR4LqgWrkNdqPCXnpl5b8_zq7lD_8gCzLiFRHJ4NPJIPjfPcRObmzU0LbKge-jTEw6dlEeWvEjqYOPMUDz3IUSeUhLvqSVaiKPaSXdh79HfFY9xZOAjycg3Vq1TVBO2_jCMZLTIp1kiKojt_NtCi3-avsdBLkG1Xbr_wzxB831s_o |
CODEN | CIRUAL |
CitedBy_id | crossref_primary_10_3109_08958378_2014_897776 crossref_primary_10_1111_j_1471_4159_2011_07595_x crossref_primary_10_1152_ajplung_00261_2011 crossref_primary_10_1089_ars_2024_0659 crossref_primary_10_3390_cells12010067 crossref_primary_10_1016_j_pharmthera_2015_12_005 crossref_primary_10_1155_2013_161687 crossref_primary_10_1186_s12989_024_00576_8 crossref_primary_10_1002_2211_5463_12077 crossref_primary_10_1016_j_envres_2019_03_034 crossref_primary_10_1016_j_jhep_2015_07_020 crossref_primary_10_1016_j_tox_2012_02_004 crossref_primary_10_1038_s41401_020_00502_6 crossref_primary_10_3109_08958378_2015_1030481 crossref_primary_10_1371_journal_pone_0106855 crossref_primary_10_1146_annurev_environ_012220_010602 crossref_primary_10_1016_j_envres_2020_110105 crossref_primary_10_1038_s41598_022_13001_x crossref_primary_10_1007_s00109_022_02183_6 crossref_primary_10_1152_ajplung_00244_2020 crossref_primary_10_1016_j_pharmthera_2021_107996 crossref_primary_10_1089_ars_2017_7394 crossref_primary_10_1186_s12302_023_00754_z crossref_primary_10_1152_ajpheart_00804_2020 crossref_primary_10_1111_j_1549_8719_2011_00137_x crossref_primary_10_3390_ijms22052419 crossref_primary_10_1016_j_scitotenv_2017_03_064 crossref_primary_10_1093_toxsci_kft136 crossref_primary_10_1016_j_redox_2023_102995 crossref_primary_10_1186_s12989_014_0053_5 crossref_primary_10_1186_s12989_016_0177_x crossref_primary_10_1016_j_taap_2019_114770 crossref_primary_10_1016_j_ecoenv_2019_03_068 crossref_primary_10_1093_toxsci_kfad020 crossref_primary_10_1016_j_envpol_2023_121715 crossref_primary_10_3389_fphys_2015_00312 crossref_primary_10_1080_08958378_2020_1845257 crossref_primary_10_1161_CIRCRESAHA_111_241174 crossref_primary_10_1161_CIRCRESAHA_113_301487 crossref_primary_10_1016_j_scitotenv_2012_07_034 crossref_primary_10_1016_j_taap_2011_09_007 crossref_primary_10_1186_s12989_014_0077_x crossref_primary_10_1016_j_cmet_2024_05_008 crossref_primary_10_1016_j_redox_2022_102580 crossref_primary_10_1007_s12035_013_8425_7 crossref_primary_10_1016_j_bbagen_2016_05_010 crossref_primary_10_1016_j_pharmthera_2021_107890 crossref_primary_10_1016_j_freeradbiomed_2023_10_396 crossref_primary_10_1080_08958378_2024_2316241 crossref_primary_10_1161_ATVBAHA_112_300552 crossref_primary_10_1038_s41569_020_0371_2 crossref_primary_10_1038_cmi_2015_62 crossref_primary_10_1016_j_ecoenv_2022_113632 crossref_primary_10_3390_antiox10111787 crossref_primary_10_1002_jat_4418 crossref_primary_10_1016_j_biopha_2019_108737 crossref_primary_10_18699_VJ19_517 crossref_primary_10_3390_ijerph192013226 crossref_primary_10_1007_s11892_015_0603_8 crossref_primary_10_1161_ATVBAHA_120_315219 crossref_primary_10_1161_JAHA_119_013041 crossref_primary_10_1093_toxsci_kfx154 crossref_primary_10_14814_phy2_14980 crossref_primary_10_1016_j_jhazmat_2021_125504 crossref_primary_10_1111_jth_12006 crossref_primary_10_1186_1743_8977_9_40 crossref_primary_10_3109_08958378_2013_801004 crossref_primary_10_1073_pnas_1616070114 crossref_primary_10_1007_s11356_021_12350_w crossref_primary_10_1177_1721727X221104389 crossref_primary_10_3390_nu10121838 crossref_primary_10_1016_j_envpol_2018_04_048 crossref_primary_10_3389_fncel_2021_647643 crossref_primary_10_1016_j_envres_2022_113378 crossref_primary_10_1016_j_arbr_2015_04_013 crossref_primary_10_1089_ars_2021_0272 crossref_primary_10_1016_j_mad_2023_111857 crossref_primary_10_1111_obr_13552 crossref_primary_10_1016_j_ecoenv_2021_112586 crossref_primary_10_1371_journal_pone_0088582 crossref_primary_10_1016_j_envpol_2023_121603 crossref_primary_10_1016_j_jhep_2012_10_008 crossref_primary_10_1016_j_arbres_2014_10_005 crossref_primary_10_1097_MCP_0b013e32834f210a crossref_primary_10_1007_s00018_012_1013_6 crossref_primary_10_1093_toxsci_kft107 crossref_primary_10_5812_ijhls_79606 crossref_primary_10_1016_j_taap_2013_11_013 crossref_primary_10_1016_j_molimm_2019_04_033 crossref_primary_10_1016_j_neubiorev_2018_06_002 crossref_primary_10_1111_jpi_12636 crossref_primary_10_1016_j_scitotenv_2014_04_065 crossref_primary_10_3389_fpubh_2023_967047 crossref_primary_10_1016_j_freeradbiomed_2020_01_004 crossref_primary_10_3390_genes12071058 crossref_primary_10_3109_08958378_2012_667455 crossref_primary_10_1289_EHP2966 crossref_primary_10_1152_ajpheart_00162_2015 crossref_primary_10_1080_01616412_2021_1968705 crossref_primary_10_3390_antiox9121243 crossref_primary_10_1016_j_envpol_2021_118677 crossref_primary_10_1016_j_heliyon_2024_e32840 crossref_primary_10_1016_j_freeradbiomed_2017_06_019 crossref_primary_10_1590_fst_38320 crossref_primary_10_1016_j_mam_2016_02_003 crossref_primary_10_1371_journal_pone_0138762 crossref_primary_10_1371_journal_pone_0050767 crossref_primary_10_3390_ijerph17082927 crossref_primary_10_1161_CIRCRESAHA_112_281006 crossref_primary_10_1097_EDE_0000000000000273 crossref_primary_10_1007_s00059_024_05234_5 crossref_primary_10_1016_j_jaccao_2024_04_003 crossref_primary_10_2478_fzm_2022_0021 crossref_primary_10_1177_0192623312464531 crossref_primary_10_1152_ajpheart_00369_2015 crossref_primary_10_1016_j_toxlet_2018_11_002 crossref_primary_10_5194_acp_21_16363_2021 crossref_primary_10_1016_j_tcm_2017_08_014 crossref_primary_10_1007_s00011_022_01647_2 crossref_primary_10_1161_JAHA_113_000212 crossref_primary_10_1111_bph_14949 crossref_primary_10_1016_j_tiv_2012_04_009 crossref_primary_10_1016_j_neuro_2016_01_003 crossref_primary_10_1093_eurheartj_ehw294 crossref_primary_10_1016_j_fct_2023_113981 crossref_primary_10_1111_j_1365_2796_2012_02566_x crossref_primary_10_1002_jbt_21475 crossref_primary_10_3390_ijerph17103561 crossref_primary_10_2217_fca_12_43 crossref_primary_10_1016_j_envpol_2024_124415 crossref_primary_10_1038_s41366_020_00714_0 crossref_primary_10_1016_j_ab_2021_114310 crossref_primary_10_1186_1476_069X_13_102 crossref_primary_10_1016_j_ecoenv_2022_113368 crossref_primary_10_1161_HYPERTENSIONAHA_123_20617 crossref_primary_10_1111_apha_12899 crossref_primary_10_1007_s12012_013_9208_0 crossref_primary_10_1016_j_ecoenv_2020_111186 crossref_primary_10_1016_j_yjmcc_2014_06_003 crossref_primary_10_1093_eurheartj_ehy481 crossref_primary_10_1161_ATVBAHA_111_244509 crossref_primary_10_1038_s41598_022_24653_0 crossref_primary_10_3390_biom5031399 crossref_primary_10_1093_toxsci_kfw015 crossref_primary_10_1007_s11869_023_01362_9 crossref_primary_10_1016_j_bbagen_2016_04_030 crossref_primary_10_1089_ars_2020_8090 crossref_primary_10_1016_S2213_8587_23_00361_3 crossref_primary_10_1007_s11883_021_00958_9 crossref_primary_10_1186_s12989_023_00518_w crossref_primary_10_1016_j_scitotenv_2024_171053 crossref_primary_10_1016_j_scitotenv_2023_163803 crossref_primary_10_1289_ehp_1306841 crossref_primary_10_1161_RES_0b013e31826f7938 crossref_primary_10_2139_ssrn_4046796 crossref_primary_10_1016_j_biopha_2018_04_107 crossref_primary_10_1007_s11427_021_2098_7 crossref_primary_10_1016_j_jaci_2012_07_033 crossref_primary_10_1021_acsnano_8b08517 crossref_primary_10_1007_s00395_016_0562_5 crossref_primary_10_1016_j_redox_2020_101545 crossref_primary_10_1089_ars_2020_8096 crossref_primary_10_3389_fcell_2022_897831 crossref_primary_10_1093_eurheartj_ehaa982 crossref_primary_10_1161_CIRCRESAHA_123_323613 crossref_primary_10_1016_j_freeradbiomed_2022_10_002 crossref_primary_10_15420_ecr_2022_41 crossref_primary_10_1053_j_ajkd_2022_04_008 crossref_primary_10_3389_fphys_2015_00162 crossref_primary_10_1016_j_freeradbiomed_2016_12_034 crossref_primary_10_3390_atmos12121668 crossref_primary_10_3390_atmos12040464 crossref_primary_10_3390_jcm13133816 crossref_primary_10_1016_j_bbrc_2017_05_047 crossref_primary_10_1016_j_jhazmat_2022_128368 crossref_primary_10_1289_EHP424 crossref_primary_10_3109_00207454_2015_1044088 crossref_primary_10_1016_j_mad_2017_11_007 crossref_primary_10_1038_s41598_020_71144_1 crossref_primary_10_1161_CIRCRESAHA_115_304666 crossref_primary_10_1016_j_envpol_2023_122997 crossref_primary_10_1016_j_jacc_2012_08_973 crossref_primary_10_1016_j_cpcardiol_2023_102094 crossref_primary_10_1289_ehp_1307151 crossref_primary_10_1016_j_jacc_2017_05_043 crossref_primary_10_1016_j_scitotenv_2023_163352 crossref_primary_10_1016_j_envres_2019_108890 crossref_primary_10_18632_oncotarget_23347 crossref_primary_10_1016_j_bbrc_2011_08_021 crossref_primary_10_1177_1753425916650272 crossref_primary_10_2337_db12_0190 crossref_primary_10_1016_j_chemosphere_2021_129619 crossref_primary_10_3390_ijms24010317 crossref_primary_10_3390_ijerph13080748 crossref_primary_10_4062_biomolther_2019_061 crossref_primary_10_1136_heartjnl_2014_306379 crossref_primary_10_1186_1743_8977_11_27 crossref_primary_10_3390_ijms21196996 crossref_primary_10_1152_ajpheart_00725_2020 crossref_primary_10_3390_toxics11110885 crossref_primary_10_1093_toxsci_kfy079 crossref_primary_10_1007_s10753_020_01269_y crossref_primary_10_1080_10937404_2012_632359 crossref_primary_10_1016_j_cophys_2023_100677 crossref_primary_10_1016_j_exer_2018_03_005 crossref_primary_10_4236_jep_2018_96038 crossref_primary_10_1093_cvr_cvab316 crossref_primary_10_1093_eurheartj_ehu458 crossref_primary_10_1186_s12989_018_0276_y crossref_primary_10_1164_rccm_201012_1967OC crossref_primary_10_1038_s41598_017_16490_3 crossref_primary_10_1002_tox_23584 crossref_primary_10_1093_toxsci_kfs084 crossref_primary_10_1167_iovs_61_4_23 crossref_primary_10_3109_08958378_2016_1155003 crossref_primary_10_1161_CIRCRESAHA_112_278101 crossref_primary_10_1093_ajh_hpw168 crossref_primary_10_1289_EHP212 crossref_primary_10_1161_ATVBAHA_117_309971 crossref_primary_10_1161_JAHA_118_010797 crossref_primary_10_1016_j_cophys_2018_05_002 crossref_primary_10_1016_j_toxlet_2023_06_013 crossref_primary_10_1111_j_1440_1843_2011_02109_x crossref_primary_10_1016_j_freeradbiomed_2022_02_005 crossref_primary_10_2174_1573399818666211230104327 crossref_primary_10_1093_cvr_cvz228 crossref_primary_10_1016_j_envpol_2021_116893 crossref_primary_10_1016_j_matbio_2015_12_005 crossref_primary_10_1016_j_envpol_2021_117983 crossref_primary_10_3109_10408444_2016_1149451 crossref_primary_10_1093_eurheartj_ehad886 crossref_primary_10_1016_j_fct_2023_114362 crossref_primary_10_1515_hsz_2013_0241 crossref_primary_10_1016_j_envres_2022_114841 crossref_primary_10_1016_j_freeradbiomed_2019_07_002 crossref_primary_10_1289_EHP2311 crossref_primary_10_1093_toxsci_kfu250 crossref_primary_10_1155_2013_279371 crossref_primary_10_1016_j_chemosphere_2022_133948 crossref_primary_10_1007_s11892_014_0494_0 crossref_primary_10_1002_tox_22707 crossref_primary_10_1080_01616412_2019_1609170 crossref_primary_10_1016_j_jacc_2018_07_099 crossref_primary_10_3390_nu12030616 crossref_primary_10_1080_1040841X_2020_1816894 |
Cites_doi | 10.1172/JCI29919 10.1126/science.1156995 10.1161/circresaha.108.182998 10.1080/10473289.2006.10464485 10.1080/08958370390249111 10.1172/JCI24335 10.1016/S0140-6736(02)11289-X 10.1016/j.cardiores.2007.06.016 10.1172/JCI118623 10.4049/jimmunol.173.6.3589 10.1164/ajrccm.164.5.2010160 10.1172/JCI30639 10.1080/08958370701665384 10.4049/jimmunol.180.12.7847 10.1056/NEJMsa0805646 10.1016/j.cell.2008.02.043 10.1136/thx.54.11.1027 10.1084/jem.20070657 10.1016/j.imbio.2006.05.025 10.1002/mrm.20307 10.1080/08958370590912743 10.1136/thx.51.12.1216 10.2337/db07-1061 10.1016/j.mvr.2009.08.001 10.1016/j.smim.2006.12.004 10.1016/j.amjhyper.2004.02.004 10.1074/jbc.M606721200 10.1016/j.neuint.2007.06.014 10.1161/circulationaha.109.857888 10.1042/BJ20061184 10.1513/pats.200406-035MS 10.1172/JCI28549 10.1056/NEJMoa066314 10.4049/jimmunol.172.11.6866 10.1161/ATVBAHA.108.181610 10.1161/HYPERTENSIONAHA.109.130237 10.1001/jama.294.23.3003 10.1126/science.1175202 10.1164/ajrccm.161.4.9904084 10.1056/NEJMoa054409 10.1161/CIR.0b013e3181dbece1 10.1093/aje/kwn232 10.1056/NEJMoa040203 10.4049/jimmunol.175.9.5596 10.1016/S1074-7613(03)00174-2 10.1016/S0140-6736(95)90173-6 10.1016/j.cardiores.2007.06.007 |
ContentType | Journal Article |
Copyright | 2011 American Heart Association, Inc. 2015 INIST-CNRS |
Copyright_xml | – notice: 2011 American Heart Association, Inc. – notice: 2015 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 5PM |
DOI | 10.1161/CIRCRESAHA.110.237560 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts AIDS and Cancer Research Abstracts PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef AIDS and Cancer Research Abstracts Immunology Abstracts |
DatabaseTitleList | MEDLINE CrossRef AIDS and Cancer Research Abstracts |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1524-4571 |
EndPage | 726 |
ExternalDocumentID | 10_1161_CIRCRESAHA_110_237560 21273555 24021314 10.1161/CIRCRESAHA.110.237560 |
Genre | Journal Article |
GrantInformation_xml | – fundername: NIEHS NIH HHS grantid: R01 ES015146-04 – fundername: NIEHS NIH HHS grantid: R01 ES015146 – fundername: NIEHS NIH HHS grantid: R01 ES013406 – fundername: NCRR NIH HHS grantid: UL1 RR025755 – fundername: NIEHS NIH HHS grantid: K01 ES016588 – fundername: National Institute of Environmental Health Sciences : NIEHS grantid: R01 ES015146-04 || ES |
GroupedDBID | - .Z2 01R 0R 1J1 29B 2WC 40H 4Q1 4Q2 4Q3 53G 55 5GY 5RE 5VS 71W 77Y 7O 7O~ AAAXR AAMOA AAMTA AAPBV AARTV AAXQO ABBUW ABFLS ABOCM ABXVJ ABZAD ACDDN ACEWG ACGFS ACPRK ACWDW ACWRI ACXNZ ADACO ADBBV ADNKB AE3 AENEX AFUWQ AHMBA AHULI AHVBC AIJEX AJIOK AJNYG AJYGW ALMA_UNASSIGNED_HOLDINGS AMJPA ASCII AWKKM BAWUL BOYCO BQLVK C45 CS3 DIK DU5 DUNZO E.X E3Z EBS EJD EX3 F2K F2L F2M F2N F5P FL- FRP FW0 GX1 H0 H0~ H13 HZ IKYAY IN IN~ JK3 JK8 K8S KD2 KMI KQ8 L-C L7B LI0 N9A N~7 N~B O0- O9- OAG OAH OB2 ODA OHASI OK1 OL1 OLG OLH OLU OLV OLW OLY OLZ OPUJH OUVQU OVD OVDNE OVIDH OVLEI OWW OWY OXXIT P2P PQEST PQQKQ RAH RHF RLZ RSW S4R S4S UPT V2I WH7 WOQ WOW X X3V X3W X7M Z2 ZA5 --- -~X .-D .3C .55 .GJ 08R 0R~ 18M 1CY 41~ AAGIX AAHPQ AAQKA AASOK AAUGY ABASU ABDIG ABQRW ACCJW ACGFO ACILI ACNWC ADFPA ADGGA AE6 AEETU AFDTB AFFNX AGINI AHOMT AHRYX AJNWD AKALU AKULP ALMTX AMKUR AMNEI AOHHW BS7 C1A DIWNM EEVPB FCALG GNXGY GQDEL HZ~ H~9 IKREB IPNFZ IQODW J5H JF9 JG8 MVM N~M OCUKA OJAPA ORVUJ OWU OWV OWX OWZ P-K R58 RIG T8P TEORI TR2 TSPGW VVN W3M W8F XXN XYM YFH YOC ZFV ZGI ZZMQN AAAAV AAIQE ABJNI ADHPY AHQNM AINUH AJZMW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 H94 5PM |
ID | FETCH-LOGICAL-c5740-584dc167976a44f410e2f7143d1e6c4ee0454ebdf7c3d0d7e9ed4cb87a92ef83 |
ISSN | 0009-7330 |
IngestDate | Tue Sep 17 21:25:47 EDT 2024 Fri Aug 16 02:33:00 EDT 2024 Fri Aug 23 01:42:08 EDT 2024 Sat Sep 28 07:50:13 EDT 2024 Sun Oct 22 16:06:47 EDT 2023 Thu Aug 13 19:50:26 EDT 2020 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Keywords | NADPH Monocyte Enzyme Oxidase Toll-like receptor 4 Phospholipid Toll like receptor particulate matter Vertebrata Chronic Mammalia Dysfunction oxidized phospholipids Oxidoreductases Circulatory system superoxide |
Language | English |
License | CC BY 4.0 |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-c5740-584dc167976a44f410e2f7143d1e6c4ee0454ebdf7c3d0d7e9ed4cb87a92ef83 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
OpenAccessLink | https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.237560 |
PMID | 21273555 |
PQID | 907152368 |
PQPubID | 23462 |
PageCount | 11 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3085907 proquest_miscellaneous_907152368 crossref_primary_10_1161_CIRCRESAHA_110_237560 pubmed_primary_21273555 pascalfrancis_primary_24021314 wolterskluwer_health_10_1161_CIRCRESAHA_110_237560 |
ProviderPackageCode | L-C C45 7O~ AARTV OLH ASCII OLG AAMOA ODA ABZAD ABBUW JK3 ADNKB JK8 H0~ 1J1 OLV OLU OLW OLZ OLY F2K F2M F2L F2N OHASI AHVBC AJNYG FL- KMI K8S OVLEI AJIOK OPUJH V2I S4R S4S 4Q1 DUNZO OAG 4Q2 OVDNE 4Q3 AMJPA OAH OVD 71W AHULI OB2 ACEWG .Z2 N~7 IKYAY OVIDH AWKKM 40H N~B OUVQU X3V X3W ACDDN ACWRI BOYCO AIJEX AAXQO AAMTA AAAXR E.X OWW OWY 01R ACXNZ OL1 ABXVJ IN~ KD2 OXXIT 77Y ACWDW FW0 |
PublicationCentury | 2000 |
PublicationDate | 2011-March-18 |
PublicationDateYYYYMMDD | 2011-03-18 |
PublicationDate_xml | – month: 03 year: 2011 text: 2011-March-18 day: 18 |
PublicationDecade | 2010 |
PublicationPlace | Hagerstown, MD |
PublicationPlace_xml | – name: Hagerstown, MD – name: United States |
PublicationTitle | Circulation research |
PublicationTitleAlternate | Circ Res |
PublicationYear | 2011 |
Publisher | American Heart Association, Inc Lippincott Williams & Wilkins |
Publisher_xml | – name: American Heart Association, Inc – name: Lippincott Williams & Wilkins |
References | 15153505 - J Immunol. 2004 Jun 1;172(11):6866-74 16113470 - Proc Am Thorac Soc. 2005;2(1):61-7 15496621 - N Engl J Med. 2004 Oct 21;351(17):1721-30 8994518 - Thorax. 1996 Dec;51(12):1216-22 17275323 - Semin Immunol. 2007 Feb;19(1):24-32 17904249 - Neurochem Int. 2008 Jan;52(1-2):256-64 15356101 - J Immunol. 2004 Sep 15;173(6):3589-93 16414948 - JAMA. 2005 Dec 21;294(23):3003-10 17200718 - J Clin Invest. 2007 Jan;117(1):185-94 18835862 - Am J Epidemiol. 2008 Nov 15;168(10):1161-8 18423196 - Cell. 2008 Apr 18;133(2):235-49 15804936 - Inhal Toxicol. 2005 Apr;17(4-5):189-97 12401239 - Lancet. 2002 Oct 19;360(9341):1184-5 17875676 - J Exp Med. 2007 Oct 1;204(10):2449-60 16805397 - J Air Waste Manag Assoc. 2006 Jun;56(6):709-42 14648359 - Inhal Toxicol. 2003 Dec;15(14):1465-78 19620518 - Hypertension. 2009 Sep;54(3):659-67 19682464 - Microvasc Res. 2009 Dec;78(3):294-300 16341265 - J Clin Invest. 2006 Jan;116(1):115-24 19910640 - Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):653-61 17217339 - Biochem J. 2007 May 1;403(3):451-61 15690504 - Magn Reson Med. 2005 Jan;53(1):69-75 17364026 - J Clin Invest. 2007 Apr;117(4):902-9 18403674 - Science. 2008 May 2;320(5876):674-7 19720932 - Circulation. 2009 Sep 15;120(11):941-8 20458016 - Circulation. 2010 Jun 1;121(21):2331-78 16237045 - J Immunol. 2005 Nov 1;175(9):5596-600 17678883 - Cardiovasc Res. 2007 Sep 1;75(4):659-68 17267905 - N Engl J Med. 2007 Feb 1;356(5):447-58 11549540 - Am J Respir Crit Care Med. 2001 Sep 1;164(5):826-30 21415405 - Circ Res. 2011 Mar 18;108(6):644-7 16920499 - Immunobiology. 2006;211(6-8):609-18 19122178 - Circ Res. 2009 Feb 27;104(4):541-9 17885684 - J Clin Invest. 2007 Oct;117(10):2952-61 10525563 - Thorax. 1999 Nov;54(11):1027-32 12871640 - Immunity. 2003 Jul;19(1):71-82 18268047 - Diabetes. 2008 May;57(5):1254-61 17855668 - N Engl J Med. 2007 Sep 13;357(11):1075-82 19644120 - Science. 2009 Jul 31;325(5940):612-6 19164188 - N Engl J Med. 2009 Jan 22;360(4):376-86 10764314 - Am J Respir Crit Care Med. 2000 Apr;161(4 Pt 1):1213-7 7741860 - Lancet. 1995 Jan 21;345(8943):176-8 8621776 - J Clin Invest. 1996 Apr 15;97(8):1916-23 18432983 - Curr Protoc Immunol. 2007 May;Chapter 14:Unit 14.12 18523248 - J Immunol. 2008 Jun 15;180(12):7847-58 15363831 - Am J Hypertens. 2004 Sep;17(9):852-60 17213198 - J Biol Chem. 2007 Mar 9;282(10):7416-23 17987463 - Inhal Toxicol. 2007 Nov;19(14):1107-19 17689510 - Cardiovasc Res. 2007 Sep 1;75(4):679-89 e_1_3_5_27_2 e_1_3_5_25_2 e_1_3_5_23_2 e_1_3_5_44_2 e_1_3_5_46_2 e_1_3_5_48_2 e_1_3_5_29_2 e_1_3_5_40_2 e_1_3_5_42_2 e_1_3_5_7_2 e_1_3_5_9_2 e_1_3_5_3_2 e_1_3_5_5_2 e_1_3_5_39_2 e_1_3_5_16_2 e_1_3_5_37_2 e_1_3_5_14_2 e_1_3_5_12_2 e_1_3_5_35_2 e_1_3_5_10_2 e_1_3_5_33_2 e_1_3_5_50_2 e_1_3_5_31_2 e_1_3_5_28_2 e_1_3_5_26_2 e_1_3_5_24_2 e_1_3_5_22_2 e_1_3_5_43_2 e_1_3_5_45_2 e_1_3_5_47_2 e_1_3_5_49_2 e_1_3_5_2_2 e_1_3_5_41_2 e_1_3_5_8_2 e_1_3_5_20_2 e_1_3_5_4_2 e_1_3_5_6_2 e_1_3_5_38_2 e_1_3_5_15_2 e_1_3_5_36_2 e_1_3_5_13_2 e_1_3_5_34_2 e_1_3_5_11_2 Chen LC (e_1_3_5_18_2) 2003 e_1_3_5_32_2 e_1_3_5_19_2 Takeda K (e_1_3_5_17_2) 2007; 14 US Environmental Protection Agency (e_1_3_5_21_2) 2006 e_1_3_5_51_2 e_1_3_5_30_2 |
References_xml | – ident: e_1_3_5_41_2 doi: 10.1172/JCI29919 – ident: e_1_3_5_14_2 doi: 10.1126/science.1156995 – ident: e_1_3_5_23_2 doi: 10.1161/circresaha.108.182998 – ident: e_1_3_5_51_2 doi: 10.1080/10473289.2006.10464485 – ident: e_1_3_5_34_2 doi: 10.1080/08958370390249111 – ident: e_1_3_5_40_2 doi: 10.1172/JCI24335 – ident: e_1_3_5_3_2 doi: 10.1016/S0140-6736(02)11289-X – ident: e_1_3_5_47_2 doi: 10.1016/j.cardiores.2007.06.016 – ident: e_1_3_5_44_2 doi: 10.1172/JCI118623 – ident: e_1_3_5_25_2 doi: 10.4049/jimmunol.173.6.3589 – ident: e_1_3_5_12_2 doi: 10.1164/ajrccm.164.5.2010160 – ident: e_1_3_5_13_2 doi: 10.1172/JCI30639 – ident: e_1_3_5_31_2 doi: 10.1080/08958370701665384 – ident: e_1_3_5_29_2 doi: 10.4049/jimmunol.180.12.7847 – ident: e_1_3_5_5_2 doi: 10.1056/NEJMsa0805646 – ident: e_1_3_5_15_2 doi: 10.1016/j.cell.2008.02.043 – ident: e_1_3_5_11_2 doi: 10.1136/thx.54.11.1027 – ident: e_1_3_5_46_2 doi: 10.1084/jem.20070657 – ident: e_1_3_5_39_2 doi: 10.1016/j.imbio.2006.05.025 – ident: e_1_3_5_22_2 doi: 10.1002/mrm.20307 – ident: e_1_3_5_19_2 doi: 10.1080/08958370590912743 – ident: e_1_3_5_27_2 doi: 10.1136/thx.51.12.1216 – ident: e_1_3_5_42_2 doi: 10.2337/db07-1061 – ident: e_1_3_5_20_2 doi: 10.1016/j.mvr.2009.08.001 – ident: e_1_3_5_16_2 doi: 10.1016/j.smim.2006.12.004 – volume: 14 start-page: 12 year: 2007 ident: e_1_3_5_17_2 article-title: Toll-like receptors publication-title: Curr Protoc Immunol contributor: fullname: Takeda K – ident: e_1_3_5_45_2 doi: 10.1016/j.amjhyper.2004.02.004 – ident: e_1_3_5_49_2 doi: 10.1074/jbc.M606721200 – ident: e_1_3_5_50_2 doi: 10.1016/j.neuint.2007.06.014 – ident: e_1_3_5_4_2 doi: 10.1161/circulationaha.109.857888 – ident: e_1_3_5_24_2 doi: 10.1042/BJ20061184 – ident: e_1_3_5_33_2 doi: 10.1513/pats.200406-035MS – ident: e_1_3_5_36_2 doi: 10.1172/JCI28549 – ident: e_1_3_5_9_2 doi: 10.1056/NEJMoa066314 – ident: e_1_3_5_28_2 doi: 10.4049/jimmunol.172.11.6866 – ident: e_1_3_5_43_2 doi: 10.1161/ATVBAHA.108.181610 – ident: e_1_3_5_35_2 doi: 10.1161/HYPERTENSIONAHA.109.130237 – ident: e_1_3_5_10_2 doi: 10.1001/jama.294.23.3003 – ident: e_1_3_5_37_2 doi: 10.1126/science.1175202 – ident: e_1_3_5_32_2 doi: 10.1164/ajrccm.161.4.9904084 – volume-title: Methods for Exposing Rodents and Cells to Concentrated Ambient PM using a VACES year: 2003 ident: e_1_3_5_18_2 contributor: fullname: Chen LC – volume-title: Air Quality Criteria for Particulate Matter year: 2006 ident: e_1_3_5_21_2 contributor: fullname: US Environmental Protection Agency – ident: e_1_3_5_7_2 doi: 10.1056/NEJMoa054409 – ident: e_1_3_5_6_2 doi: 10.1161/CIR.0b013e3181dbece1 – ident: e_1_3_5_8_2 doi: 10.1093/aje/kwn232 – ident: e_1_3_5_2_2 doi: 10.1056/NEJMoa040203 – ident: e_1_3_5_26_2 doi: 10.4049/jimmunol.175.9.5596 – ident: e_1_3_5_38_2 doi: 10.1016/S1074-7613(03)00174-2 – ident: e_1_3_5_30_2 doi: 10.1016/S0140-6736(95)90173-6 – ident: e_1_3_5_48_2 doi: 10.1016/j.cardiores.2007.06.007 |
SSID | ssj0014329 |
Score | 2.5381098 |
Snippet | RATIONALE:Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled ambient... Chronic exposure to ambient air-borne particulate matter of < 2.5 μm (PM₂.₅) increases cardiovascular risk. The mechanisms by which inhaled ambient particles... Rationale: Chronic exposure to ambient air-borne particulate matter of <2.5 μm (PM 2.5 ) increases cardiovascular risk. The mechanisms by which inhaled ambient... RATIONALE:: Chronic exposure to ambient air-borne particulate matter of <2.5 mu m (PM2.5) increases cardiovascular risk. The mechanisms by which inhaled... |
SourceID | pubmedcentral proquest crossref pubmed pascalfrancis wolterskluwer |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 716 |
SubjectTerms | Administration, Inhalation Air Pollutants - adverse effects Animals Biological and medical sciences Environmental Exposure Enzyme Activation Fundamental and applied biological sciences. Psychology Inflammation - etiology Lung - metabolism Male Mice Mice, Inbred Strains Mice, Knockout Mice, Transgenic NADPH Oxidases - metabolism Oxidation-Reduction Particle Size Particulate Matter - administration & dosage Particulate Matter - adverse effects Phospholipids - metabolism Time Factors Toll-Like Receptor 4 - metabolism Vascular Diseases - chemically induced Vascular Diseases - etiology Vertebrates: cardiovascular system |
Title | Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways |
URI | https://www.ncbi.nlm.nih.gov/pubmed/21273555 https://search.proquest.com/docview/907152368 https://pubmed.ncbi.nlm.nih.gov/PMC3085907 |
Volume | 108 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKkBDShLiOcJn8wFuVkosTJ49VARXGJpiKNO0lsmNHjcbaqm0Y49dzjuOkKSsIeInaXJw039fjY_uc7xDySkoeBDzPXRaK1AWD57uSF9KVseAFU4olCqcGjk_i8Rf24Sw66_W6UUvVWg7yHzvzSv4HVdgHuGKW7D8g2zYKO-Az4AtbQBi2f4WxVbbtF-gqLswJWI0LY1IxSQfl--c4A9iHgXeFoVe1bjNc0QagqusVdm2GBd9K0T8Zvvk07s-_lwq6N7OyMPl4ylB-dXolrlddX3ZULnNb_KtvNYPaueUjcbkogFzTX4KQzNw3Llbpqg2nLFvLY-urnE_1hbA9qlGPFKaZ80qKctmdpvBNnJa1rNqa1oC5LKoLrrS210s6JOtaUl6nYN608DFa-NH70xEwdDgeYh7DIAh5VJcl6KC-uDSwo4Q9OFXRpsNrwxCbQ7fI7YCnEY7djz5vFqFYGKQ26Qvu-nrnPY2YdN3KlmezvwAcxdeiro6ya_hyMwp3_2qOERKrC5Mg0XFzJvfJPTs-ocOabA9IT88ekjvHNgLjEVlazlHkHO1wjtacow3nqOUcbThHG87RDucocI4azlHLOQqco8g52nDuMZm8ezsZjV1bt8PNI848F3xalePyHo8FYwXzPR0UHF6n8nWcM61R9lFLVfA8VJ7iOtWK5TLhIg10kYRPyN5sPtNPCU09wXiiVBHrBKiTJGHug4-cCy8oYplKhwyaV54tanWWzIxqYz_bwAXfvayGyyGHW8C0V-Eiox_6zCG0QSoDQ4urZ2Km59UqS8EZj4IwThxyUAO3udgywCF8C9L2BNRw3z4yK6dGyz1EgUGPOyTYAj-rs6D__GOe_fZBnpO7m__gC7K3Xlb6JTjPa3loKP4TxLbIPg |
link.rule.ids | 230,315,786,790,891,27957,27958 |
linkProvider | Colorado Alliance of Research Libraries |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Chronic+fine+particulate+matter+exposure+induces+systemic+vascular+dysfunction+via+NADPH+oxidase+and+TLR4+pathways&rft.jtitle=Circulation+research&rft.au=Kampfrath%2C+Thomas&rft.au=Maiseyeu%2C+Andrei&rft.au=Ying%2C+Zhekang&rft.au=Shah%2C+Zubair&rft.date=2011-03-18&rft.eissn=1524-4571&rft.volume=108&rft.issue=6&rft.spage=716&rft_id=info:doi/10.1161%2FCIRCRESAHA.110.237560&rft_id=info%3Apmid%2F21273555&rft.externalDocID=21273555 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-7330&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-7330&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-7330&client=summon |