Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters

• Published in: Pharmaceutics Vol. 15; no. 3; p. 838
• Main Authors: Kang, Dong Wook, Kim, Kyung Min, Kim, Ju Hee, Cho, Hea-Young
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Acids; Animals; Antimalarials; artesunate; Chromatography; Coronaviruses; COVID-19; Dosage and administration; Drug dosages; drug repurposing; Ions; Malaria; minimal physiologically-based pharmacokinetic (PBPK) model; Particle size; Pharmacokinetics; Physiological aspects; Physiology; pyronaridine; Severe acute respiratory syndrome coronavirus 2; Testing; South Korea; United States > US; Japan; COVID-19; pyronaridine; drug repurposing; artesunate; minimal physiologically-based pharmacokinetic (PBPK) model

A fixed-dose combination of pyronaridine and artesunate, one of the artemisinin-based combination therapies, has been used as a potent antimalarial treatment regimen. Recently, several studies have reported the antiviral effects of both drugs against severe acute respiratory syndrome coronavirus two...