Fabricating a PDA-Liposome Dual-Film Coated Hollow Mesoporous Silica Nanoplatform for Chemo-Photothermal Synergistic Antitumor Therapy

• Published in: Pharmaceutics Vol. 15; no. 4; p. 1128
• Main Authors: Fan, Chuanyong, Wang, Xiyu, Wang, Yuwen, Xi, Ziyue, Wang, Yuxin, Zhu, Shuang, Wang, Miao, Xu, Lu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2023; MDPI
• Subjects: Biocompatibility; Biotechnology industry; Breast cancer; Cancer; Cancer therapies; Carbon; Chemical properties; chemo-photothermal therapy; Chemotherapy; Dopamine; Dosage and administration; doxorubicin; Drug delivery systems; Drug resistance; Drugs; Efficiency; Ethanol; Graphene; Health aspects; hollow mesoporous silica; Lipids; liposome-TPGS; Liposomes; Materials; Nanomaterials; Nanoparticles; Permeability; Photochemotherapy; polydopamine; Polyethylene glycol; Radiation therapy; Testing; Tumors; Vehicles; China; hollow mesoporous silica; liposome-TPGS; polydopamine; doxorubicin; chemo-photothermal therapy

In this study, we synthesized hollow mesoporous silica nanoparticles (HMSNs) coated with polydopamine (PDA) and a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-modified hybrid lipid membrane (denoted as HMSNs-PDA@liposome-TPGS) to load doxorubicin (DOX), which achieved the integration of...