Bacillus thuringiensis Cry14A family proteins as novel anthelmintics against gastrointestinal nematode parasites

• Published in: PLoS neglected tropical diseases Vol. 18; no. 10; p. e0012611
• Main Authors: Hoang, Duy, Flanagan, Kelly, Ding, Qian, Cazeault, Nicholas R., Li, Hanchen, Díaz-Valerio, Stefani, Rus, Florentina, Darfour, Esther A., Kass, Elizabeth, Petersson, Katherine H., Nielsen, Martin K., Liesegang, Heiko, Ostroff, Gary R., Aroian, Raffi V.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.10.2024; Public Library of Science (PLoS)
• Subjects: Animals; Anthelmintics; Anthelmintics - pharmacology; Bacillus thuringiensis; Bacillus thuringiensis - chemistry; Bacillus thuringiensis - genetics; Bacillus thuringiensis Toxins - genetics; Bacterial proteins; Bacterial Proteins - genetics; Biology and Life Sciences; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - genetics; Care and treatment; Control; Endotoxins - genetics; Female; Gastrointestinal diseases; Health aspects; Hemolysin Proteins - genetics; Hemolysin Proteins - pharmacology; Medical research; Medicine and Health Sciences; Medicine, Experimental; Mice; Nematoda; Nematoda - drug effects; Nematoda - genetics; Nematode Infections - drug therapy; Nematode Infections - parasitology; Parasites; Physiological aspects; United States

Bacillus thuringiensis crystal (Cry) proteins have been expressed in commercial transgenic crops for nearly 30 years, providing safe and effective control of insect pests and significantly reducing the application of hazardous chemical pesticides. B . thuringiensis crystal proteins have also been sh...